| 叠氮钠对模型大鼠学习记忆能力的影响 |
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| 引用本文： | 张兰,张如意,叶翠飞,李斌,李林.叠氮钠对模型大鼠学习记忆能力的影响[J].中国组织工程研究与临床康复,2001,5(1):52-53. |
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| 作者姓名： | 张兰 张如意 叶翠飞 李斌 李林 |
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| 作者单位： | 首都医科大学宣武医院,北京脑老化重点实验室,北京100053 |
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| 基金项目： | 北京市自然科学基金资助项目(No37982006),国家人事部资助优秀留学回国人员科研项目(1998)，北京市科委资助项目(No.952601800),北京市科委资助北京市重点实验室项目(No.951890600)。 |
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| 摘 要： | 目的观察叠氯钠对模型大鼠学习记忆能力及脑内胆碱乙酰基转移酶(ChAT)活性的影响，探讨线粒体缺陷损伤学习记忆功能的可能机制。方法SD大鼠皮下埋植Alzet微泵，连续恒速给予叠氮钠共28d，给药1mg/kg·h和2mg/kg·h两个剂量组。Morris水迷宫、通道式水迷宫检测动物学习记忆能力。放射化学法分区测定脑皮层和海马ChAT活性。结果大鼠水迷宫游出时间及距离延长、错误次数增加。大鼠皮层和海马ChAT活性降低。结论Cox活性下降可以导致动物学习记忆能力及脑内ChAT活性下降，使乙酰胆碱Ach代谢的障碍，可能是模型大鼠学习记忆能力下降的机制之一。
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| 关 键 词： | 叠氮钠 学习记忆 水迷宫 线粒体 动物模型 胆碱乙酰基转移酶 |
| 文章编号： | 1007-5496(2001)01-0052-03 |
| 修稿时间： | 2000年9月14日 |
Infusion of sodium azide by minipump impairs cearning-memory ability in model rats |
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| ZHANG Lan,ZHANG Ru yi,YE Cui fei,et al..Infusion of sodium azide by minipump impairs cearning-memory ability in model rats[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2001,5(1):52-53. |
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| Authors: | ZHANG Lan ZHANG Ru yi YE Cui fei |
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| Institution: | ZHANG Lan,ZHANG Ru yi,YE Cui fei,et al.Xuan Wu Hospital of Capital University of Medical Sciences,Beijing 100053,China |
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| Abstract: | Objective To observe the influence of mitochondrial deficiency on learning-memory ability and cholinergic system in brain.Method Rats were administrated with 1 mg/kg· h or 2 mg/kg· h subcutaneously via a Alzet minipump for 28 days.Then learning-memory ability of rats were determined.ChAT activity in hippocampus and cortex of rats were measured Result Drugged rats showed learning-memory deficit in both waternazes.ChAT activity was significantly inhibited in hippocampus and cortex of model rats.Conclusion The results of present study indicate COX deficiency can induce decline of learning-memory in rats which may be related to the damage of cholinergic system. |
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| Keywords: | sodium azide learning-memory watermaze mitochondria animal model choline-acetyl-transfertase |
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