| 热凝脑膜中动脉对硝酸甘油致偏头痛大鼠三叉神经尾核c-fos基因表达的影响 |
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| 引用本文： | 朱晓凤,韩月臣,熊文萍,逯素梅,李建峰,王海波,樊兆民.热凝脑膜中动脉对硝酸甘油致偏头痛大鼠三叉神经尾核c-fos基因表达的影响[J].山东医大基础医学院学报,2010(1). |
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| 作者姓名： | 朱晓凤 韩月臣 熊文萍 逯素梅 李建峰 王海波 樊兆民 |
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| 作者单位： | 山东大学附属省立医院耳鼻咽喉-头颈外科;山东省临床医学研究院眼耳鼻喉科学研究所; |
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| 基金项目： | 山东省科技攻关计划课题(2007GG20002) |
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| 摘 要： | 目的探讨热凝脑膜中动脉对硝酸甘油诱发的偏头痛大鼠三叉神经尾核c-fos基因表达的影响。方法48只健康雌性Wistar大鼠随机分为4组(每组12只):生理盐水组(A组),硝酸甘油组(B组,10mg/kg),假手术组(C组),手术组(D组)。观察各组大鼠行为学表现,成功建模后每组随即平分为2小组分别采用RT-PCR和West-ernblot法检测大鼠三叉神经尾核c-fos基因表达。结果各组大鼠挠头、爬笼及耳红等行为学评分(x珋±s)分别为2.33±0.74,39.57±5.44,37.87±4.68,15.6±3.30。4组大鼠三叉神经尾核c-fosmRNA相对表达水平分别为0.50±0.08,0.94±0.12,0.91±0.09,0.71±0.08;c-fos蛋白相对表达水平分别为0.57±0.08,0.93±0.09,0.93±0.09,0.73±0.11。A组大鼠三叉神经尾核c-fosmRNA和蛋白相对表达水平低于B组,C组和D组,且D组大鼠三叉神经尾核c-fosmRNA和蛋白相对表达水平低于B组和C组,差异有统计学意义(P<0.05),但B组与C组之间差异无统计学意义(P>0.05)。结论热凝脑膜中动脉...
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| 关 键 词： | 偏头痛 脑膜中动脉 三叉神经尾核 c-fos基因 大鼠 Wistar |
Effects of heating coagulation of the middle meningeal artery on c-fos expression in the trigeminal caudalis nucleus in migraine rats triggered by nitroglycerin |
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| ZHU Xiao-feng,HAN Yue-chen,XIONG Wen-ping,LU Su-mei,LI Jian-feng,WANG Hai-bo,FAN Zhao-min.Effects of heating coagulation of the middle meningeal artery on c-fos expression in the trigeminal caudalis nucleus in migraine rats triggered by nitroglycerin[J].Journal of Preclinical Medicine College of Shandong Medical University,2010(1). |
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| Authors: | ZHU Xiao-feng HAN Yue-chen XIONG Wen-ping LU Su-mei LI Jian-feng WANG Hai-bo FAN Zhao-min |
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| Institution: | ZHU Xiao-feng1,HAN Yue-chen1,XIONG Wen-ping1,LU Su-mei2,LI Jian-feng2,WANG Hai-bo1,2,FAN Zhao-min1 (1. Otolaryngology-Head , Neck Surgery,Provincial Hospital Affiliated to Sh,ong University,Jinan 250021,China,2. Institute of Eye , ENT,Sh,ong Clinic Research Institute,China) |
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| Abstract: | Objective To detect the influence of heating coagulation of the middle meningeal artery on c-fos expression in the trigeminal caudalis nucleus in migraine rats triggered by nitroglycerin. Methods Forty-eight female Wistar rats were randomly assigned to four groups,the isotonic saline group (group A),the nitroglycerin group (group B),the operation group (group C),and the sham operation group (group D),with 12 subjects in each group and each group was subdivided into another two equal groups after successfull... |
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| Keywords: | Migraine Middle meningeal artery Trigeminal caudalis nucleus C-fos Genes Rats Wistar |
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