山莨菪碱和肠道吸附剂对兔急性油酸肺损伤的作用

目的：探讨脂质过氧化和中分子物质在兔实验性急性油酸肺损伤中的作用以及山莨菪碱和肠道吸附剂对油酸肺损伤的防治效应。方法：１８ 只兔由耳缘静脉注入油酸０．１ ｍ ｌ／ｋｇ 体重形成急性肺损伤模型，其中１０ 只以山莨菪碱１０ ｍ ｇ／ｋｇ 体重和肠道吸附剂１ ｇ／ｋｇ 体重分别处理（各５ 只）作为处理组，另８只作为实验组。结果：油酸组与生理盐水对照组相比，全血超氧化物歧化酶（ＳＯＤ）和支气管肺泡灌洗液（ＢＡＬＦ）中谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力显著减低（Ｐ＜ ０．０５ 和Ｐ＜ ０．０１）；血浆和ＢＡＬＦ中的丙二醛（ＭＤＡ）和丙二醛与脂质系数（ＭＤＡ／Ｌｉｐｉｄ）均明显增加（Ｐ＜ ０．０５～０．０１）；ＢＡＬＦ中的ＡＬＰ、ＡＬＢ和肺系数都显著增加（Ｐ＜ ０．０１）；血浆和ＢＡＬＦ中的ＭＭＳ也显著增加（Ｐ＜ ０．０１）。山莨菪碱组和肠道吸附剂组分别与油酸组相比，ＳＯＤ与ＧＳＨ－Ｐｘ 活力均增加（Ｐ＜０．０５～０．０１）；除了血浆ＭＤＡ外，其它相应指标均有减低（Ｐ＜ ０．０５ 或Ｐ＜ ０．０１）。结论：脂质过氧化和中分子物质参与油酸肺损伤的发病，山莨菪碱和肠道吸附剂对兔油酸肺损伤有防治作用。

Actions of Anisodamine or Enterosorbent in Lung Injury of Rabbits Induced by Oleic Acid

Objective: Actions of lipid peroxide, middle molecules substance (MMS) and effects of prevention and cure of anisodamine or enterosorbent were studied in experimental lung injury induced by oleic acid of rabbits. Methods: 18 rabbits were made model of lung injury injected with oleic acid (OA) 0.1 ml/kg. bw intravenously and were divided into experimental group and two treatment groups. Results: Activity of SOD in blood and GSH Px in broncho alveolar lavage fluid (BALF) were obviously lower, MDA, MDA/Lipid and MMS in plasma and MDA, MDA/Lipid, ALP, ALB, MMS in BALF were significantly higher in OA group than that of control group (P<0.05~0.01). Activity of SOD and GSH Px in anisodamine group or enterosorbent group were obviously higher than that of OA group (P<0.05~0.01), but the others were reduced to varying degrees and there were statistical significances (P<0.05~0.01). Conclusion: The results suggested that lipid peroxide and MMS were involved in the pathogenesis of lung injury induced by OA, anisodamine and enterosorbent could prevent and cure it.