The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer

Breast Cancer Research and Treatment - Preclinical evidence suggests that natural killer cell (NK-cell) function and myokines facilitate the protective effects of exercise for breast cancer...     

Evaluation of cerebral perfusion reserve using 5% CO2 and SPECT neuroperfusion imaging

Anatomic features of carotid artery stenosis, as defined angiographically, do not necessarily correlate with the hemodynamic significance of the narrowing. The concept of regional cerebral vasodilatory (or perfusion) reserve has been advocated as a means of defining the hemodynamic compromise associated with carotid lesions. We evaluated the feasibility of using SPECT imaging with 5% CO2 using I-123 IMP (N-isopropyl iodoamphetamine) or Tc-99m HMPAO (hexamethylpropylene amineoxime) to measure cerebral perfusion reserve. Imaging was performed on six asymptomatic subjects and one patient with a history of transient ischemic attacks but no evidence of carotid artery disease. A perfusion reserve index (PRI) was defined to represent the percent increase in blood flow during 5% CO2 breathing in regions supplied by the middle cerebral artery normalized for injected dose and changes in blood pressure. Significant increases in cerebral perfusion were seen in six of the seven subjects studied while breathing the 5% CO2 (P less than 0.01). The mean of the PRI values for the seven subjects was 32%, with a range of -5% to 58%. We conclude that SPECT imaging with IMP or HMPAO can be used to quantitatively measure the cerebral perfusion response to 5% CO2.     

A mobile anaesthetic--rapid evacuation from hospital.

The use of the Triservice Anaesthetic Apparatus for the emergency evacuation of an anaesthetised patient from nuclear, biological and chemical (NBC) collective protection in a tented hospital complex in the Gulf is described. Because of its compact size and portability the Triservice Anaesthetic Apparatus may prove to be ideal for use in emergency evacuation.     

Selection of medical tests based on linear nonseparability of data sets: a study on evaluation of liver diseases tests

A new method of solving the problem of medical tests selection is proposed. This method is based on the notion of linear nonseparability of data. A measure of linear nonseparability is computed by minimization of the perceptron criterion function. A multistage strategy of search of the minimum sufficient tests subset is described. This strategy is reliable in the sense that it allows us to find the least (globally) sufficient number of tests. The considerations are illustrated on a liver diseases data example.