全文获取类型
收费全文 | 2360篇 |
免费 | 136篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 50篇 |
妇产科学 | 73篇 |
基础医学 | 381篇 |
口腔科学 | 88篇 |
临床医学 | 222篇 |
内科学 | 559篇 |
皮肤病学 | 58篇 |
神经病学 | 226篇 |
特种医学 | 28篇 |
外科学 | 219篇 |
综合类 | 10篇 |
一般理论 | 2篇 |
预防医学 | 207篇 |
眼科学 | 17篇 |
药学 | 177篇 |
中国医学 | 6篇 |
肿瘤学 | 170篇 |
出版年
2023年 | 37篇 |
2022年 | 40篇 |
2021年 | 139篇 |
2020年 | 73篇 |
2019年 | 105篇 |
2018年 | 105篇 |
2017年 | 76篇 |
2016年 | 68篇 |
2015年 | 84篇 |
2014年 | 114篇 |
2013年 | 155篇 |
2012年 | 247篇 |
2011年 | 235篇 |
2010年 | 115篇 |
2009年 | 97篇 |
2008年 | 140篇 |
2007年 | 149篇 |
2006年 | 125篇 |
2005年 | 101篇 |
2004年 | 111篇 |
2003年 | 82篇 |
2002年 | 56篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1998年 | 6篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1964年 | 1篇 |
1959年 | 2篇 |
排序方式: 共有2510条查询结果,搜索用时 78 毫秒
1.
Leopoldo Pérez de Isla Raquel Arroyo-Olivares Ovidio Muñiz-Grijalvo José Luis Diaz-Díaz Daniel Zambón Francisco Fuentes Juan F. Sánchez Muñoz-Torrero Juan Diego Mediavilla Aurora González-Estrada Jose Pablo Miramontes-González Raimundo de Andrés Marta Mauri Daniel Mosquera José M. Cepeda Lorena Suárez Miguel Ángel Barba-Romero Rosa Argüeso Pilar Álvarez-Baños Pedro Mata 《Journal of clinical lipidology》2019,13(6):989-996
2.
Lorena Martin-Morales Sara Manzano Maria Rodrigo-Faus Adrian Vicente-Barrueco Victor Lorca Gonzalo Núñez-Moreno Paloma Bragado Almudena Porras Trinidad Caldes Pilar Garre Alvaro Gutierrez-Uzquiza 《International journal of cancer. Journal international du cancer》2023,152(2):283-297
Matrix metalloproteinase-11 (MMP11) is an enzyme with proteolytic activity against matrix and nonmatrix proteins. Although most MMPs are secreted as inactive proenzymes and are later activated extracellularly, MMP11 is activated intracellularly by furin within the constitutive secretory pathway. It is a key factor in physiological tissue remodeling and its alteration may play an important role in the progression of epithelial malignancies and other diseases. TCGA colon and colorectal adenocarcinoma data showed that upregulation of MMP11 expression correlates with tumorigenesis and malignancy. Here, we provide evidence that a germline variant in the MMP11 gene (NM_005940: c.232C>T; p.(Pro78Ser)), identified by whole exome sequencing, can increase the tumorigenic properties of colorectal cancer (CRC) cells. P78S is located in the prodomain region, which is responsible for blocking MMP11's protease activity. This variant was detected in the proband and all the cancer-affected family members analyzed, while it was not detected in healthy relatives. In silico analyses predict that P78S could have an impact on the activation of the enzyme. Furthermore, our in vitro analyses show that the expression of P78S in HCT116 cells increases tumor cell invasion and proliferation. In summary, our results show that this variant could modify the structure of the MMP11 prodomain, producing a premature or uncontrolled activation of the enzyme that may contribute to an early CRC onset in these patients. The study of this gene in other CRC cases will provide further information about its role in CRC development, which might improve patient treatment in the future. 相似文献
3.
Ignasi Esteban Carmen Pastor-Quiones Lorena Usero Montserrat Plana Felipe García Lorna Leal 《Viruses》2021,13(3)
Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure. 相似文献
4.
5.
Wilma Barcellini Anna Zaninoni Anna I. Gregorini Giulia Soverini Lorena Duca Bruno Fattizzo Juri A. Giannotta Patrizia Pedrotti Cristina Vercellati Anna P. Marcello Elisa Fermo Paola Bianchi Maria Domenica Cappellini 《British journal of haematology》2019,185(3):523-531
Iron overload (IO) is poorly investigated in the congenital haemolytic anaemias (CHAs), a heterogeneous group of rare inherited diseases encompassing abnormalities of the erythrocyte membrane and metabolism, and defects of the erythropoiesis. In this study we systematically evaluated routine iron parameters and cardiac and hepatic magnetic resonance imaging, together with erythropoietin, hepcidin, non-transferrin bound iron (NTBI), and cytokine serum levels in patients with different CHAs. We found that 40% of patients had a liver iron concentration (LIC) >4 mg Fe/g dry weight. Hepatic IO was associated with ferritin levels (P = 0·0025), transferrin saturation (TfSat, P = 0·002) and NTBI (P = 0·003). Moreover, ferritin >500 μg/l plus TfSat >60% was demonstrated as the best combination able to identify increased LIC, and TfSat alteration as more important in cases with discordant values. Possible confounding factors, such as transfusions, hepatic disease, metabolic syndrome and hereditary haemochromatosis-associated mutations, had negligible effects on IO. Erythropoietin and hepcidin levels were increased in CHAs compared with controls, correlating with LIC and ferritin, respectively. Regarding cytokines, γ-interferon (IFN-γ) was increased, and both interleukin 6 and IFN-γ levels positively correlated with ferritin and hepcidin levels. Overall, these findings suggest the existence of a vicious cycle between chronic haemolysis, inflammatory response and IO in CHAs. 相似文献
6.
John Lennon Silva Cunha Amanda Almeida Leite Thamiris de Castro Abrantes Lorena Passoni Vervloet Thayn Melo de Lima Morais Gerson de Oliveira Paiva Neto Tatiana Nayara Librio Kimura Snia Maria Soares Ferreira Ricardo Luiz Cavalcanti de Albuquerque‐Júnior Aline Corrêa Abraho Mario Jos Romaach Bruno Augusto Benevenuto de Andrade Oslei Paes de Almeida Ciro Dantas Soares 《Journal of cutaneous pathology》2021,48(1):24-33
7.
Sevilla-Cermeño Laura Rautio Daniel Andrén Per Hillborg Maria Silverberg-Morse Maria Lahera Guillermo Mataix-Cols David Fernández de la Cruz Lorena 《European child & adolescent psychiatry》2020,29(9):1289-1299
European Child & Adolescent Psychiatry - Pediatric body dysmorphic disorder (BDD) is challenging to treat. This study aimed to establish the prevalence of insomnia in youth with BDD and explore... 相似文献
8.
Ming Li Ling Wang Dian-Chun Shi Jia-Nee Foo Zhong Zhong Chiea-Chuen Khor Chiara Lanzani Lorena Citterio Erika Salvi Pei-Ran Yin Jin-Xin Bei Li Wang Yun-Hua Liao Jian Chen Qin-Kai Chen Gang Xu Geng-Ru Jiang Jian-Xin Wan Meng-Hua Chen Nan Chen Hong Zhang Yi-Xin Zeng Zhi-Hong Liu Jian-Jun Liu Xue-Qing Yu 《Journal of the American Society of Nephrology : JASN》2020,31(12):2949
9.
10.
Rizzo Manglio Miguel Bluthgen Mara Virginia Recondo Gonzalo Naveira Martin Perfetti Aldo Rizzi Florencia Kuzminin Alejandro Faura Victoria Cerini Matas Videla Alejandro Silva Carlos Lupinacci Lorena Minatta Nicols 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(6):1057-1064
International Journal of Clinical Oncology - Immune-checkpoint inhibitors (ICIs) are standard treatments for metastatic non-small cell lung cancer (NSCLC). Patients with poor performance status... 相似文献