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BACKGROUND: In previous experiments, we have confirmed that platelet rich fibrin has the ability of osteoinduction, and have conducted a preliminary study on its microstructure and biomechanics. However, little is reported on its histology research.
OBJECTIVE: To compare the histological changes after implanting platelet-rich fibrin, Bio-Oss and autologous bone and to analyze the pros and cons of platelet-rich fibrin implantation for repair of bone defects.
METHODS: As previously reported, animal models of critical bone defects were established respectively on the bilateral femoral condyles of 12 beagle dogs. Then, platelet-rich fibrin, Bio-Oss+collagen membrane (Bio-Oss group) and autologous bone (autologous bone group)+collagen membrane were respectively implanted. At 3, 6, 8 and 12 months, one experimental dog from each group was killed, respectively, and histological observation was performed. Another beagle dog as blank control was enrolled to establish the animal model of critical bone defects, with no implantation.
RESULTS AND CONCLUSION: At 3, 6, 8 and 12 months after implantation, there were significant differences in the new bone formation speed and amount between the platelet-rich fibrin group, Bio-Oss group and autologous bone group. These three kinds of bone grafts all had osteoinductive ability to different extents. In the platelet-rich fibrin group, the osteogenic effects were better at 3 and 6 months, and the new bone was similar to natural one; in the autologuos bone group, bone necrosis was noticeable at 3 and 6 months, but the osteogenic effects became better at 8 months, and the new bone was similar to natural one at 12 months; in the Bio-oss group, the osteogenic effects were similar to those in the platelet-rich fibrin group, but the residual of Bio-oss was visible at 12 months; in the blank control group, no bone formed at 3 months, indicating the animal model of critical bone defects was made successfully. In brief, the platelet-rich fibrin has good osteoinductive ability, with shorter time and better quality. 相似文献
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目的:寻求科学客观公正评价卫生专业技术人才的评价方式。方法:分析目前国内卫生专业技术资格评价的主要方式。结果:定性评价方式和定量评价方式各有优劣。评价方式的选择应遵循有效性、科学性、可操作性、可持续发展等原则,结论:对目前评价方式的分析,应采取低覆盖面的量化评价方式,即基础要素定性、重点要素定量,同时应建立评价指标与权重的动态调整机制。 相似文献
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董露 《中国超声医学杂志》2011,27(4)
孕妇,20岁.孕1产0,孕39周.超声所见:单胎头位,双顶径:9.6 cm,股骨长:7.7 cm,头围:32.9 cm,腹围:39.7 cm,羊水无回声区最深约5.6 cm,羊水指数18.5 cm,见胎心搏动,胎盘位于子宫前壁,厚约3.4 cm,成熟度Ⅱ级,其内见椭圆形实质性5.43 cm×3.08 cm肿块,表面规则,边界清楚,内部回声紊乱,其强度略低于胎盘,彩超显示肿块内丰富血流信号(图1).超声提示:晚孕,宫内单胎头位存活. 相似文献
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目的:通过建立beagle犬股骨髁的骨缺损模型,观察富血小板纤维蛋白(platelet-rich fibrin,PRF)诱导骨再生过程中新生骨的微观结构,评价PRF修复骨缺损的特点和优势,为PRF在诱导骨再生及颌骨重建的临床应用提供新的实验依据。方法:在实验犬股骨髁制备骨缺损,按Choukroun方法制备PRF膜,将PRF膜、Bio-Oss骨替代材料及自体骨骨松质随机填入3处骨缺损。12周、24周处死动物并取材,采用微焦点计算机断层摄影系统(microfocus computerizedtomography system,Micro-CT)检测分析新生骨的几何信息和结构信息。结果:PRF新生诱导骨骨小梁结构呈板状,厚度较厚,连续性和成熟度良好,数量稍少,接近自体骨组的成骨情况,优于Bio-Oss组;观察期内均数随时间延长,有向天然骨组衍变的趋势;PRF诱导成骨表现为向心性的特点。结论:PRF可诱导新生骨形成,成骨效果接近生理状态,表现为向心性成骨方式,具有良好的应用前景。 相似文献
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BACKGROUND: In clinical, the research on the method and the material of the soft tissue defect of the operation area has been in depth. It will have a positive impact on our exploration and research in this field through the establishment of reliable experimental animal oral soft tissue defect model. 相似文献
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目的 分析子痫的发生原因,识别先兆症状、抽搐的预防及血压监控.方法 通过我院连续发生的3例子痫.结果 子痫患者经过积极处理及整体护理,无并发症,痊愈出院.结论 加强围产期保健及早诊断和规范治疗,是降低子痫发生率、确保母婴安全的关键. 相似文献