稳心颗粒对原发性高血压患者心律失常及心率变异性的影响

目的观察稳心颗粒对原发性高血压患者心律失常及心率变异性的影响。方法将167例原发性高血压患者随机分为两组,稳心颗粒组（84例）及对照组（83例）。两组患者均口服卡托普利,起始量6.25~12.5 mg/次,3次/d。稳心颗粒组还给予步长稳心颗粒9g口服,3次/d。疗程均为4周。观察心律失常临床疗效及心率变异性时域指标。结果稳心颗粒组心律失常治愈率70%,总有效率93%。对照组心律失常治愈率38%,总有效率85%。两组治疗效果比较有显著性差异（P〈0.05）;稳心颗粒组与对照组治疗前两组间心率变异性各时域指标比较,差异无统计学意义（P〉0.05）;治疗4周后,稳心颗粒组SDNN、SDANN、SDNN-Index较对照组升高更显著,ST段下移减小更明显,与对照组比较,差异有统计学意义（P〈0.05）。结论原发性高血压患者合并心律失常合并应用稳心颗粒可明显改善心律失常及心率变异性,对预防心源性猝死及恶性心律失常的发生有积极的作用。     

球囊逆行静脉阻断术联合内镜注射治疗胃肾分流静脉曲张患者3例

球囊阻断经逆行静脉闭塞术(balloon retrograde venous occlusion,BRTO)是治疗胃肾分流的胃底静脉曲张的主要方法,能有效防止异位栓塞[1-3],但是,逆行静脉注射硬化剂可能存在胃底静脉曲张消失不完全,需再次胃镜下注射治疗[4]。单纯胃镜下注射硬化治疗,由于存在分流通道,异位栓塞的风险较高。因此,我们采用了改良球囊逆行静脉阻断术联合胃镜下注射硬化治疗胃肾分流胃底静脉曲张患者3例,现报道如下。     

高尿酸血症与急性冠脉综合征的相关性

目的:探讨高尿酸血症与急性冠脉综合征之间的相关性。方法:对178例冠心病患者进行血尿酸测定,并与正常对照组比较;同时将冠心病组患者分为急性冠脉综合征组和稳定性心绞痛组,进行血尿酸水平比较。结果:冠心病组血尿酸水平显著高于正常对照组(P<0.05);高尿酸血症患者的冠心病发生率明显高于正常尿酸者;急性冠脉综合征组血清尿酸水平显著高于稳定性心绞痛组(P<0.05)。结论:高尿酸血症与急性冠脉综合征发生密切相关。     

DHS和PFNA两种方法在治疗老年性股骨粗隆间骨折的评价

目的评价动力髋(DHS)与股骨近端髓内钉(PFNA)两种手术方式治疗老年股骨粗隆间骨折的疗效。方法 112例老年股骨粗隆间骨折患者,随机分为DHS方案组(44例),PFNA方案组(68例)。结果所有患者均获得12个月以上随访,未出现患者因并发症而发生死亡。手术时间、术中出血量、术后完全负重时间、骨折愈合时间:DHS组与PFNA组比较均具有统计学意义(均P<0.05);术后髋关节Harris评分,PFNA组与DHS组相比,差异有统计学意义(P<0.05)。结论 PFNA在治疗老年性股骨粗隆间骨折较DHS更有优势。     

中国南方四省区流行的HIV-1 CRF01_AE病毒株基因特征研究

Objective To analyze the genetic characteristics of HIV-1 CRF01_AE strains prevailing in. the four provinces of southern China. Methods Plasma samples were collected from the newly diagnosed HIV-1 individuals reported in 2006 in Guangdong, Guangxi, Jiangxi and Hunan province. The gag and env gene fragments were amplified from RNA template extracted from plasma using RT and nested PCR methods. CRF01_AE sequences were analyzed by phylogcnetie methods and characterized by calculating the genetic distance and Entropy analysis. Results Two main epidemic clusters were found to exist in the CRF01 AE strains from 210 HIV-1 CRF01 AE infected individuals collected in the 4 provinces, southern China. It was found that no international reference strain was closely correlated with cluster Ⅰ , which including 123 samples. The strains in cluster Ⅱ, consisting 57 cases of samples, were closely related with the strains identified in Vietnam. Genetic distance analysis of gag and env genes showed that the diversity of cluster Ⅰ was obviously less than that of cluster Ⅱ. Data on nucleotide polymorphism showed that nucleotides compositions of 42 sites in gag and 40 sites in env wer esignificantly different between the two clusters. When compared with cluster Ⅱ , the polymorphism decreased at 61 nucleotide sites but increased at 21 sites in cluster Ⅰ. Conclusion This was the first report describing that two main epidemic clusters were existed in CRF01_AE strains prevailing in the 4 provinces, Southern China. The vires in cluster Ⅰ was the dominant strain in this region, with shorter period of circulation and higher proportion seen in the HIV-infected population, which might belong to CRF01_AE strain with certain features facilitating the spread of the virus. The virus in cluster Ⅱ was highly homology with the CRF01_AE strains from Vietnam, and seemed to have had several events of epidemics in populations in border regions of China and Vietnam.     

江西人群CCL3L1基因拷贝数与HIV感染相关性研究

目的研究江西省HIV/AIDS(艾滋病感染者/艾滋病病人)人群趋化性细胞因子配体蛋白CCL3L1(CC chemokine ligand 3-like-1)的拷贝数及其与HIV病毒(艾滋病病毒)易感性及艾滋病进展的关系。方法收集192例HIV/AIDS和131例阳性者配偶阴性血样标本,提取基因组DNA,应用PRT(the Paralogue Ratio Test)法检测其CCL3L1基因拷贝数,计算江西省人群CCL3L1基因拷贝数中位数,用SPPS统计软件分析CCL3L1拷贝数与HIV感染的关系。结果江西人群CCL3L1基因拷贝数中位数为2;HIV慢性感染者与健康人无显著性差异(P0.05);第一次CD4淋巴细胞数与基因拷贝数的变化有显著相关(P0.05)。结论江西人群的CCL3L1基因拷贝数与HIV易感性无相关性,与感染进程有一定相关性。     

射频消融术治疗室上性心动过速39例分析

射频消融术（RFCA）自1987年应用于临床,十几年间得到飞速发展,现已成为治疗阵发性室上性心动过速、心房扑动、心房纤颤、房性心动过速及某些室性心律失常的一线方法,成功率高,并发症少。现将我院2006年1月至2008年12月应用该技术治疗室上性心动过速（PSVT）39例的情况作一回顾性分析。     

老年冠心病患者生活质量的影响因素多元回归调查

目的：评估老年冠心病患者的生活质量（quality of life,QOL）,分析影响其QOL的相关因素。方法：采用问卷对江西省吉安市中心人民医院门诊及住院的冠心病（CHD）患者100例进行调查,该问卷由健康调查问卷、西雅图心绞痛问卷、社会支持量表等组成。结果：老年冠心病患者的健康简表评分在8个维度比健康老年人群低（P〈0.05）,其中生理职能维度下降最明显;影响QOL的因素有生理功能的改变、心理精神因素和社会支持。结论：老年冠心病患者的生活质量明显低于健康老年人群,造成老年冠心病患者QOL下降的主要因素是生理功能改变导致的日常生活受限,抑郁情绪及社会支持对QOL的改变也有一定程度的影响。