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Objective To investigate the effect of hemodialysis with hemo-perfusion on microinflammatory and vascular endothelial function of chronic hemodialysis patients. Methods Twenty hemodialysis patients were divided into two groups, 10 patients received hemodialysis therapy for four times (as control group), and 15 patients received hemodialysis with hemoperfusion(HD+HP) therapy for four times. The level of TNF-α and sVCAM-1 were detected before therapy and after therapy for four times. Results The level of TNF-α and sVCAM-1 in chronic hemodialysis patients were higher than that of control group; The level of TNF-α were positive correlated with the level of sVCAM-1 (r=0.674, P<0.05) before therapy; The level of TNF-α and sVCAM-1 in hemo-perfusion group patients decreased after therapy for 4 times. There was statistically difference between before and after therapy (P<0. 05); while in control group, both of them showed no statistically different (P>0.05). Conclusions Microinflammatory possibly lead to vascular endothelial function damage in chronic hemodialysis patients.Hemodialysis with hemo-perfusion could effectively reduce microinflammation and alleviate vascular endothelial function damage in chronic hemodialysis patients. 相似文献
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Objective To investigate the effect of hemodialysis with hemo-perfusion on microinflammatory and vascular endothelial function of chronic hemodialysis patients. Methods Twenty hemodialysis patients were divided into two groups, 10 patients received hemodialysis therapy for four times (as control group), and 15 patients received hemodialysis with hemoperfusion(HD+HP) therapy for four times. The level of TNF-α and sVCAM-1 were detected before therapy and after therapy for four times. Results The level of TNF-α and sVCAM-1 in chronic hemodialysis patients were higher than that of control group; The level of TNF-α were positive correlated with the level of sVCAM-1 (r=0.674, P<0.05) before therapy; The level of TNF-α and sVCAM-1 in hemo-perfusion group patients decreased after therapy for 4 times. There was statistically difference between before and after therapy (P<0. 05); while in control group, both of them showed no statistically different (P>0.05). Conclusions Microinflammatory possibly lead to vascular endothelial function damage in chronic hemodialysis patients.Hemodialysis with hemo-perfusion could effectively reduce microinflammation and alleviate vascular endothelial function damage in chronic hemodialysis patients. 相似文献
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Objective To investigate the effect of hemodialysis with hemo-perfusion on microinflammatory and vascular endothelial function of chronic hemodialysis patients. Methods Twenty hemodialysis patients were divided into two groups, 10 patients received hemodialysis therapy for four times (as control group), and 15 patients received hemodialysis with hemoperfusion(HD+HP) therapy for four times. The level of TNF-α and sVCAM-1 were detected before therapy and after therapy for four times. Results The level of TNF-α and sVCAM-1 in chronic hemodialysis patients were higher than that of control group; The level of TNF-α were positive correlated with the level of sVCAM-1 (r=0.674, P<0.05) before therapy; The level of TNF-α and sVCAM-1 in hemo-perfusion group patients decreased after therapy for 4 times. There was statistically difference between before and after therapy (P<0. 05); while in control group, both of them showed no statistically different (P>0.05). Conclusions Microinflammatory possibly lead to vascular endothelial function damage in chronic hemodialysis patients.Hemodialysis with hemo-perfusion could effectively reduce microinflammation and alleviate vascular endothelial function damage in chronic hemodialysis patients. 相似文献
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老年人急性肾功能衰竭的临床特点 总被引:4,自引:0,他引:4
随着老年人口的迅速增长 ,老年急性肾功能衰竭(ARF)的人数不断增加。为探讨其临床特点 ,本文对 1993~ 1997年我院收治的老年急性肾功能衰竭病例作一回顾性分析 ,现报道如下。1 资料和方法1 1 一般资料 :1993~ 1997年在两院住院的 15 1例ARF病人均符合ARF的诊断[1] 。将其分为老年组和对照组进行分析 ,老年组 47例 ,男 34例 ,女 13例 ,年龄 6 0~ 80岁 ,平均 (6 9 47± 5 75 )岁 ;对照组 10 4例 ,男 5 8例 ,女 46例 ,年龄 13~ 5 9岁 ,平均 (35 5 7± 13 5 )岁。老年组与对照组治疗前尿素氮 (BUN)分别为 (32 78± 15 38)… 相似文献
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老年人急性肾功能衰竭的临床特点 总被引:3,自引:0,他引:3
目的:探讨老年急性肾功能衰竭(ARF)的临床特点,方法:将151例ARF病人分为老年组(47例)和对照组(104例),并比较两组病人的临床资料、治疗方法和预后。结果老年组引起ARF最常邮病因是感染,明显高于对照组(P<0.01),而肾实质性疾病引起的ARF明显低于对照组(P<0.01)。多脏器功能衰竭的发生率、病死率均明显高于对照组(P<0.01)。治疗开始前血清肌酐水平明显低于对照组(P<0.01)。接受透析治疗病例数明显低于对照组P<0.01)。结论老年ARF的原发疾病及临床经过有其特殊性。加强透析治疗,尤其早期预防透析是治疗成功的关键,预后与年龄、原发病能否控制及透析时机的选择有关。 相似文献
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目的探讨血液透析串联血液灌流对维持性血液透析患者促炎因子及血管内皮功能的影响。方法我院透析中心血液透析患者25例。10例行单纯血液透析治疗,15例血液透析串联血液灌流治疗,选择10例健康人作为正常对照。观察与单纯血液透析相比,串连灌流治疗前、连续4次强化治疗后促炎因子TNF—a及VCAM一1的改变。结果维持性血液透析患者血中TNF—a、sVCAM-1的水平明显高于正常人。治疗前MHD患者血TNF—a与sVCAM-1水平呈显著正相关关系(r=0.674,P〈0.05)。患者血液透析串联血液灌流连续4次治疗后血中TNF—a、VCAM-1水平均明显下降。而单纯血液透析治疗组,TNF—a、sVCAM-1无明显改变。结论血液透析患者体内炎症状态可能导致了血管内皮功能损伤。血液透析串联血液灌流改善了患者体内微炎症状态并减轻血管内皮功能损伤。 相似文献
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Objective To investigate the effect of hemodialysis with hemo-perfusion on microinflammatory and vascular endothelial function of chronic hemodialysis patients. Methods Twenty hemodialysis patients were divided into two groups, 10 patients received hemodialysis therapy for four times (as control group), and 15 patients received hemodialysis with hemoperfusion(HD+HP) therapy for four times. The level of TNF-α and sVCAM-1 were detected before therapy and after therapy for four times. Results The level of TNF-α and sVCAM-1 in chronic hemodialysis patients were higher than that of control group; The level of TNF-α were positive correlated with the level of sVCAM-1 (r=0.674, P<0.05) before therapy; The level of TNF-α and sVCAM-1 in hemo-perfusion group patients decreased after therapy for 4 times. There was statistically difference between before and after therapy (P<0. 05); while in control group, both of them showed no statistically different (P>0.05). Conclusions Microinflammatory possibly lead to vascular endothelial function damage in chronic hemodialysis patients.Hemodialysis with hemo-perfusion could effectively reduce microinflammation and alleviate vascular endothelial function damage in chronic hemodialysis patients. 相似文献
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Objective To investigate the effect of hemodialysis with hemo-perfusion on microinflammatory and vascular endothelial function of chronic hemodialysis patients. Methods Twenty hemodialysis patients were divided into two groups, 10 patients received hemodialysis therapy for four times (as control group), and 15 patients received hemodialysis with hemoperfusion(HD+HP) therapy for four times. The level of TNF-α and sVCAM-1 were detected before therapy and after therapy for four times. Results The level of TNF-α and sVCAM-1 in chronic hemodialysis patients were higher than that of control group; The level of TNF-α were positive correlated with the level of sVCAM-1 (r=0.674, P<0.05) before therapy; The level of TNF-α and sVCAM-1 in hemo-perfusion group patients decreased after therapy for 4 times. There was statistically difference between before and after therapy (P<0. 05); while in control group, both of them showed no statistically different (P>0.05). Conclusions Microinflammatory possibly lead to vascular endothelial function damage in chronic hemodialysis patients.Hemodialysis with hemo-perfusion could effectively reduce microinflammation and alleviate vascular endothelial function damage in chronic hemodialysis patients. 相似文献