全文获取类型
收费全文 | 389784篇 |
免费 | 25878篇 |
国内免费 | 3191篇 |
专业分类
耳鼻咽喉 | 5358篇 |
儿科学 | 8619篇 |
妇产科学 | 10265篇 |
基础医学 | 54380篇 |
口腔科学 | 12051篇 |
临床医学 | 31200篇 |
内科学 | 80657篇 |
皮肤病学 | 8798篇 |
神经病学 | 27903篇 |
特种医学 | 14341篇 |
外国民族医学 | 84篇 |
外科学 | 61808篇 |
综合类 | 10973篇 |
现状与发展 | 1篇 |
一般理论 | 66篇 |
预防医学 | 18327篇 |
眼科学 | 9887篇 |
药学 | 31935篇 |
7篇 | |
中国医学 | 2516篇 |
肿瘤学 | 29677篇 |
出版年
2021年 | 2787篇 |
2019年 | 3076篇 |
2018年 | 5038篇 |
2017年 | 3803篇 |
2016年 | 3879篇 |
2015年 | 4497篇 |
2014年 | 6251篇 |
2013年 | 8036篇 |
2012年 | 10978篇 |
2011年 | 11226篇 |
2010年 | 6791篇 |
2009年 | 6262篇 |
2008年 | 10147篇 |
2007年 | 11016篇 |
2006年 | 10827篇 |
2005年 | 9932篇 |
2004年 | 9357篇 |
2003年 | 9074篇 |
2002年 | 8710篇 |
2001年 | 28679篇 |
2000年 | 29229篇 |
1999年 | 23961篇 |
1998年 | 5125篇 |
1997年 | 4191篇 |
1996年 | 3775篇 |
1995年 | 3557篇 |
1994年 | 3150篇 |
1993年 | 2887篇 |
1992年 | 16172篇 |
1991年 | 14921篇 |
1990年 | 14250篇 |
1989年 | 14058篇 |
1988年 | 12656篇 |
1987年 | 12122篇 |
1986年 | 11160篇 |
1985年 | 10366篇 |
1984年 | 6940篇 |
1983年 | 5621篇 |
1982年 | 2728篇 |
1979年 | 5487篇 |
1978年 | 3353篇 |
1977年 | 2974篇 |
1975年 | 2643篇 |
1974年 | 3072篇 |
1973年 | 2872篇 |
1972年 | 2833篇 |
1971年 | 2781篇 |
1970年 | 2518篇 |
1969年 | 2550篇 |
1968年 | 2258篇 |
排序方式: 共有10000条查询结果,搜索用时 143 毫秒
1.
Osama Y Safdar Rana M Baghdadi Sereen A Alahmadi Bana E Fakieh Amaal M Algaydi 《World Journal of Clinical Pediatrics》2022,11(1):14-26
Whether the underlying mutations are homozygous, heterozygous, or co-inherited with other hemoglobinopathies, sickle cell disease is known to afflict the kidneys, leading to the clinical entity known as sickle cell nephropathy (SCN). Although common, SCN remains diagnostically elusive. Conventional studies performed in the context of renal disorders often fail to detect early stage SCN. This makes the quest for early diagnosis and treatment more challenging, and it increases the burden of chronic kidney disease-related morbidity among patients. Novel diagnostic tools have been employed to overcome this limitation. In this study, we discuss various biomarkers of SCN, including those employed in clinical practice and others recently identified in experimental settings, such as markers of vascular injury, endothelial dysfunction, tubulo-glomerular damage, and oxidative stress. These include kidney injury molecule-1, monocyte chemoattractant protein-1, N-acetyl-B-D-glucosaminidase, ceruloplasmin, orosomucoid, nephrin, and cation channels, among others. Furthermore, we explore the potential of novel biomarkers for refining diagnostic and therapeutic approaches and describe some obstacles that still need to be overcome. We highlight the importance of a collaborative approach to standardize the use of promising new biomarkers. Finally, we outline the limitations of conventional markers of renal damage as extensions of the pathogenic process occurring at the level of the organ and its functional subunits, with a discussion of the expected pattern of clinical and biochemical progression among patients with SCN. 相似文献
2.
肝细胞癌(HCC)是最常见的恶性肿瘤之一。尽管在早期诊断和个体化治疗方面取得了进展,但经根治性切除等治疗后,HCC患者的临床预后仍不佳,复发率高。因此,在HCC患者中识别准确可靠的预后标志物是必要的。作为一种新的免疫营养生物标志物,控制营养状态(CONUT)评分已被报道用于预测癌症患者的预后。本文将对术前CONUT评分与HCC肝切除术后预后的研究进展进行综述。 相似文献
3.
4.
5.
Yang Yang Shu Jing Mu Jing He Qiang Chen Fang Hu Yan Zhen Xiaofang 《Clinical rheumatology》2022,41(12):3783-3790
Clinical Rheumatology - To analyze and summarize the clinical features, diagnosis, and treatment of children with Henoch-Schönlein purpura (HSP) complicated by overt gastrointestinal bleeding... 相似文献
6.
The use of radiation for primary liver cancers has historically been limited because of the risk of radiation-induced liver disease. Treatment fields have become more conformal because of several technical advances, and this has allowed for dose escalation. Stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy, is now able to safely treat liver tumors to ablative doses while sparing functional liver parenchyma by using highly conformal therapy. Several retrospective and small prospective studies have examined the use of SBRT for liver cancers; however, there is a lack of well-powered randomized studies to definitively guide management in these settings. Recent advances in systemic therapy for primary liver cancers have improved outcomes; however, the optimal selection criteria for SBRT as a local therapy remain unclear among other liver-directed options such as radiofrequency ablation, transarterial chemoembolization, and radioembolization. 相似文献
7.
8.
Peng L. Q. Wu X. X. Chen G. Cai H. Z. Tang Y. P. Chen Q. Y. Chen X. Y. 《Bulletin of experimental biology and medicine》2022,173(3):335-340
Bulletin of Experimental Biology and Medicine - This study aimed to explore the effects of Wenyang Zhenshuai granules (WZG) on the morphology of cardiomyocytes, cell viability, and the expression... 相似文献
9.
10.
Post-induction hypotension is common and associated with postoperative complications. We hypothesised that pneumatic leg compression reduces post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy. In this double-blind randomised study, patients were allocated randomly to the pneumatic leg compression group (n = 50) or control (n = 50). In the intervention group, pneumatic leg compression was initiated before induction of anaesthesia. In the control group, pneumatic leg compression was initiated 20 min after anaesthesia induction. The primary outcome was the incidence of post-induction hypotension in these groups. Post-induction hypotension was defined as systolic blood pressure < 90 mmHg during the first 20 min after induction. Haemodynamic variables and area under the curve of post-induction systolic blood pressure over time were assessed. Complications associated with pneumatic leg compression were recorded, including: peripheral neuropathy; compartment syndrome; extensive bullae beneath the leg sleeves; and pulmonary thromboembolism. The incidence of post-induction hypotension decreased in the pneumatic leg compression group compared with that in the control group; 5 (10%) vs. 29 (58%), respectively, p < 0.001. In the pneumatic leg compression group, the lowest systolic, diastolic and mean blood pressures 20 min after induction of anaesthesia were significantly greater than the control group. Pneumatic leg compression resulted in an increased area under the curve of systolic blood pressure in the first 20 min after induction, p = 0.001. There were no pneumatic leg compression-related complications. Pneumatic leg compression reduced post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy, suggesting that it is an effective and safe intervention to prevent post-induction hypotension among elderly patients undergoing general anaesthesia. 相似文献