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Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery 下载免费PDF全文
Kim Boshuisen MD Monique M. J. van Schooneveld MSc Cuno S. P. M. Uiterwaal MD PhD J. Helen Cross MD PhD Sue Harrison MSc Tilman Polster MD Marion Daehn MSc Sarina Djimjadi MSc Dilek Yalnizoglu MD Guzide Turanli MD Robert Sassen MD Christian Hoppe MSc PhD Stefan Kuczaty MD Carmen Barba MD PhD Philippe Kahane MD PhD Susanne Schubert‐Bast MD Gitta Reuner MSc PhD Thomas Bast MD PhD Karl Strobl MD Hans Mayer PhD Anne de Saint‐Martin MD Caroline Seegmuller MD Agathe Laurent MSc Alexis Arzimanoglou MD PhD Kees P. J. Braun MD PhD for the TimeToStop cognitive outcome study group 《Annals of neurology》2015,78(1):104-114
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Optic neuropathy,cardiomyopathy, cognitive disability in patients with a homozygous mutation in the nuclear MTO1 and a mitochondrial MT‐TF variant 下载免费PDF全文
Majida Charif Salah Mohamed Cherif Titah Agathe Roubertie Valérie Desquiret‐Dumas Naig Gueguen Isabelle Meunier Jean Leid Frédéric Massal Xavier Zanlonghi Jacques Mercier Eric Raynaud de Mauverger Vincent Procaccio Bénédicte Mousson de Camaret Guy Lenaers Christian P. Hamel 《American journal of medical genetics. Part A》2015,167(10):2366-2374
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Anti–tumor necrosis factor alpha therapy (adalimumab) in Rasmussen's encephalitis: An open pilot study 下载免费PDF全文
Stanislas Lagarde Nathalie Villeneuve Agnès Trébuchon Elsa Kaphan Anne Lepine Aileen McGonigal Agathe Roubertie Marie‐Anne J. Barthez Valérie Trommsdorff Jérémie Lefranc Samer Wehbi Vincent des Portes Virginie Laguitton Pierre Quartier Didier Scavarda Bernard Giusiano Mathieu Milh Christine Bulteau Fabrice Bartolomei 《Epilepsia》2016,57(6):956-966
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Functional connectivity and information flow of the respiratory neural network in chronic obstructive pulmonary disease 下载免费PDF全文
Lianchun Yu Marine De Mazancourt Agathe Hess Fakhrul R. Ashadi Isabelle Klein Hervé Mal Maurice Courbage Laurence Mangin 《Human brain mapping》2016,37(8):2736-2754
Breathing involves a complex interplay between the brainstem automatic network and cortical voluntary command. How these brain regions communicate at rest or during inspiratory loading is unknown. This issue is crucial for several reasons: (i) increased respiratory loading is a major feature of several respiratory diseases, (ii) failure of the voluntary motor and cortical sensory processing drives is among the mechanisms that precede acute respiratory failure, (iii) several cerebral structures involved in responding to inspiratory loading participate in the perception of dyspnea, a distressing symptom in many disease. We studied functional connectivity and Granger causality of the respiratory network in controls and patients with chronic obstructive pulmonary disease (COPD), at rest and during inspiratory loading. Compared with those of controls, the motor cortex area of patients exhibited decreased connectivity with their contralateral counterparts and no connectivity with the brainstem. In the patients, the information flow was reversed at rest with the source of the network shifted from the medulla towards the motor cortex. During inspiratory loading, the system was overwhelmed and the motor cortex became the sink of the network. This major finding may help to understand why some patients with COPD are prone to acute respiratory failure. Network connectivity and causality were related to lung function and illness severity. We validated our connectivity and causality results with a mathematical model of neural network. Our findings suggest a new therapeutic strategy involving the modulation of brain activity to increase motor cortex functional connectivity and improve respiratory muscles performance in patients. Hum Brain Mapp 37:2736–2754, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. 相似文献