Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria

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Adaptive response of resistant cancer cells to chemotherapy

Despite advances in cancer therapeutics and the integration of personalized medicine, the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality. Upon treatment with chemotherapeutics, the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism. In this review, we summarize the mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy. We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms, with the goal of stimulating research that may facilitate the development of effective cancer therapy.     

清热化瘀方联合康复训练治疗脑卒中恢复期临床观察

目的观察清热化瘀方联合康复训练对脑中风恢复期患者神经功能改善的影响,为临床提供疗效依据。方法选取2019年6月—2019年10月收治的脑中风恢复期患者,采用随机数字表法分为2组,对照组采用常规内科治疗及康复训练,试验组在对照组治疗方案的基础上加用清热化瘀方颗粒,记录并分析2组患者治疗后的临床疗效。结果试验组患者的总有效率高于对照组,试验组治疗后神经功能缺损评分、肢体感觉及运动功能评分、肢体平衡能力评分、生活能力评分均明显优于对照组(P<0.05)。结论清热化瘀方联合康复训练可明显改善脑中风恢复期患者的症状,减轻神经功能缺损程度,提高感觉及运动功能,提高生活能力。     

复方玄驹胶囊联合山海丹颗粒治疗勃起功能障碍临床疗效观察

目的观察复方玄驹胶囊联合山海丹颗粒治疗勃起功能障碍。方法选择广西中医药大学第一附属医院仁爱分院男科门诊确诊为勃起功能障碍伴高脂血症患者30例,采用复方玄驹胶囊(口服,3粒/次,3次/天)和山海丹颗粒(1袋/次,3次/天),4周为一个疗程,服用三个疗程,采用自身前后对照的方法,根据服药前后各项指标的变化情况评价疗效。结果用药三个疗程后,患者IIEF-5评分显著性升高,患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)表达水平均降低,高密度脂蛋白(HDL-C)升高。结论复方玄驹胶囊联合山海丹颗粒可以改善高血脂症患者的勃起功能,同时降低血脂,效果显著,值得临床推广使用。     

聪耳通窍汤联合耳针对老年神经性耳鸣近远期疗效观察

目的探讨聪耳通窍汤联合耳针治疗老年神经性耳鸣患者的近远期疗效。方法选取耳鼻喉科门诊收治的老年神经性耳鸣患者136例,按随机数字表法分组,对照组68例予以耳针治疗,研究组68例在对照组基础上予以聪耳通窍汤治疗。检测比较两组间近、远期临床疗效、甲襞微循环指标、血液流变学指标以及不良反应发生率。结果治疗后,对照组总有效率为67.64%(46/68)低于研究组总有效率83.82%(57/68),具有统计学意义(P<0.05);随访6个月后,对照组总有效率64.71%(44/68)低于研究组总有效率89.71%(61/68),具有统计学意义(P<0.05);与对照组比较,研究组治疗后甲襞微循环襻周积分、管襻积分、流态积分及总积分较低,治疗后血浆黏度、高切全血黏度、低切全血黏度及红细胞压积较低,差异具有统计学意义(P<0.05);治疗中出现的不良反应为恶心、腹胀、针刺部位疼痛,两组间不良反应发生率无统计学差异(P>0.05)。结论聪耳通窍汤联合耳针治疗老年神经性耳鸣患者的近远期疗效均较好,能明显改善患者微循环状态及血液流变学指标,减轻内耳循环障碍,具有较高安全性。     

MOB1A regulates glucose deprivation-induced autophagy via IL6-STAT3 pathway in gallbladder carcinoma

MOB kinase activator 1A (MOB1A) plays an important role in many diseases and cancers. Here, we observed that MOB1A was substantially overexpressed in gallbladder carcinoma (GBC) tissues compared with nontumor tissues. The high expression of MOB1A was closely associated with poor survival in patients with GBC at advanced TNM stages. Furthermore, our study indicated that MOB1A promoted autophagy by activating the IL6/STAT3 signaling pathway and regulating the chemosensitivity to gemcitabine under glucose deprivation conditions both in vitro and in vivo. In conclusion, these findings suggested that MOB1A is critical for the development of GBC via the MOB1A-IL6/STAT3-autophagy axis.     

周晋华运用环磷酰胺联合中药紫杉治疗晚期肺癌经验

肺癌多是邪祟之物郁结留滞致使人体气血运行不畅所致,周晋华主任认为肺癌的发生与正虚邪害密不可分,而晚期肿瘤患者虚多实少,全身为虚,当以脾虚为主,“得脾胃者得中央,得中央者得天下”,局部为实,故当以缓治,固脾胃之本培人体之元,周晋华主任运用低剂量规律口服环磷酰胺联合中药紫杉片解毒散结配伍,佐以益气健脾之法治疗晚期肺癌患者,发现对身体基础状况较差的老年肿瘤患者有良好的效果,此法是从姑息性治疗角度运用中西医结合的方法将静脉化疗药环磷酰胺改为口服,在提高老年患者对化疗药物的耐受性,减轻化疗副作用方面有一定的优势,为临床治疗晚期肺癌提供一种新思维。