胸腔创伤的CT诊断及其临床意义探讨

近年来,临床上胸腔创伤性疾病的案例频频发生,对该疾病患者进行手术治疗需要较多的诊断信息,而采用CT检查法对胸腔创伤进行诊断已经成为临床上一种重要的诊断方式之一,该诊断方法由于诊断正确率高、诊断显示效果好[1],而引起诸多专家与患者的关注。本文对我院收治的42例胸腔创伤患者于手术治疗前,进行了CT检查,在手术治疗后与其结果进行对比分析,结果发现CT诊断准确     

食管混合性酸反流和低动力在非心源性胸痛发作的作用研究

目的胃食管反流病（GERD）是引起非心源性胸痛（NCCP）的最常见因素,本研究探讨酸反流和食管动力障碍在NCCP患者中的作用。 方法按照纳入、排除标准选取2018年9月至2019年6月在新疆维吾尔自治区人民医院急救中心以及微创,疝和腹壁外科住院收治的40例NCCP患者和50例典型GERD症状患者,两组患者均行食管24 h pH监测以及高分辨率食管测压监测。 结果NCCP组食管远端收缩平均积分（DCI）明显低于GERD组,并具有统计学意义（P＜0.05）,提示食管运动功能受损。在NCCP组患者中,与胸痛有关的混合性酸反流明显高于GERD组（P＜0.05）。在NCCP组患者中,与NCCP相关的反流发作在食管5、9和15cm处的反流清除时间比GERD组患者期长（28.3±4.21)s vs(22.6±3.28)s;(13.7±1.32)s vs (18.3±1.47)s;(9.58±1.02)s vs(14.3±1.06)s（P＜0.05）。 结论酸反流性质,食管运动功能受损和延缓反流清除时间与NCCP患者症状发作可能存在密切的关系。     

胃食管反流病相关非心源性胸痛患者食道患病率调查研究

ObjectiveTo investigate the prevalence and clinical characteristics of esophagus in patients with non-cardiac chest pain (NCCP). MethodsPatients who diagnosed with NCCP from January 2018 to April 2019 in Xinjiang Uygur Autonomous Region People's Hospital were selected as the study subjects. Detailed medical history, physical examination, upper gastrointestinal endoscopy, high resolution esophageal manometry and 24 h dynamic esophageal pH monitoring were performed on all subjects. ResultsThe total number of subjects was 85, of which male 45(52.94%), with an average age of 41.2±12.4 years;female was 40 (47.06%), with an average age of 43.3±10.9 years. The most common symptoms in NCCP patients were acid reflux 43.53%, dysphagia 31.76%, heartburn 24.71%. Endoscopic abnormalities of upper gastrointestinal tract accounted for 31.76%, esophageal manometry abnormalities accounted for 67.06%, and dynamic pH monitoring abnormalities accounted for 34.76%. The prevalence of GERD was 42.36% determined by upper gastrointestinal endoscopy combined with 24 h pH monitoring. According to manometric results, ineffective esophageal motility in 23.53% of NCCP patients was the most common cause of NCCP. ConclusionBy analyzing the causes of esophagogenous NCCP, it is helpful for clinicians to exclude other high-risk factors leading to chest pain and to provide appropriate treatment for their diagnosis and treatment     

极光激酶A表达在胰腺癌患者预后及临床病理因素的相关性研究

[目的]探讨胰腺癌组织中极光激酶A(aurora kinase, AURKA)表达与胰腺癌患者一般临床病理特征之间的关系及预后的相关性。[方法]100例胰腺癌患者组织标本，应用免疫组化学检测胰腺癌组织中AURKA的表达水平，分析AURKA与胰腺癌患者临床病理特征的关系，通过COX回归分析及生存期(OS)分析研究AURKA表达与胰腺癌患者预后的相关性。[结果]100例胰腺癌患者组织标本中，AURKA阳性表达57例，阴性表达为43例。胰腺癌患者AURKA阳性表达与患者肿瘤T分期、Ki-67表达相关(均P<0.05)。COX回归分析结果显示AURKA阳性表达与胰腺癌患者预后不良相关(HR:2.055;95%CI:1.263～3.344;P=0.004),采用Kaplan-Meier生存分析结果显示，AURKA的阳性表达与较低的生存率呈负相关(P<0.05)。[结论]AURKA可能在胰腺癌的发生、发展过程中起着重要的作用，AURKA的阳性表达是胰腺癌患者预后不良的独立危险因素，检测AURKA的表达可能有助于胰腺癌的治疗及预后的判断。