实验性糖尿病小鼠心肌血管紧张素Ⅱ的变化及依那普利对其影响

目的探讨实验性糖尿病小鼠心肌超微的变化及依那普利对其影响。方法雄性昆明种小鼠40只，随机分为正常组、糖尿病组、盐酸二甲双胍治疗组、盐酸二甲双胍加依那普利治疗组。实验性糖尿病鼠用链脲佐菌素(STZ)诱发糖尿病，4周后观察血管紧张素Ⅱ的变化及依那普利对其影响。结果STZ诱导的糖尿病鼠早期心肌血管紧张素Ⅱ(AngⅡ)增多。盐酸二甲双胍治疗组AngⅡ明显降低，加用依那普利治疗纽的AngⅡ进一步降低。结论依那普利对STZ-DM鼠心肌具有良好的保护作用，其保护心功能作用部分是通过调节心肌肾素-血管紧张素系统(RAS)来实现的。     

慢性乙型肝炎的疫苗治疗免疫学机制的探讨

通过对乙型肝炎疫苗治疗的13例患者的观察,分析乙型肝炎表面抗原特异细胞增殖反应及其抗原特异性T细胞分泌的细胞因子水平,以及观察疫苗治疗后的临床效果,探讨肝炎疫苗治疗慢性乙型肝炎的免疫学作用机制。血清HBVDNA水平在疫苗治疗结束后6个月显著地下降。疫苗治疗诱生6例抗原特异性CD4 T细胞的增殖反应(38 5 % ) ,同时分泌高水平的干扰素-γ和肿瘤坏死因子-α。血清HBVDNA水平在疫苗治疗结束6个月和18个月显著下降。表面抗原特异性CD4 T细胞可以间接地抑制HBV的复制,是由抗病毒细胞因子来介导     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

胰淀素与2型糖尿病及骨质疏松症

胰淀素（amylin）亦称胰岛淀粉样多肽（islet amyloid polypeptide，IAPP），发现于1987年，由CarthCooper等在英国剑桥大学从2型糖尿病病人的胰腺中提取出来，并报道了其全部氨基酸序列。胰淀紊是同胰岛素一起由胰岛B细胞分泌的一种多肽，属神经内分泌激素，与糖尿病关系密切，在骨代谢方面也起着重要作用。一直以来，糖尿病所引起的大血管、微血管并发症很受关注，而骨质疏松对糖尿病患者的影响通常不受重视。由糖尿病所引起的继发性骨质疏松症可以给糖尿病患者的健康造成严重的威胁，并且将给社会和家庭带来沉重的经济负担。迄今为止，     

胰岛素强化治疗在2型糖尿病骨折患者围手术期的应用

Objective To investigate the best way to control the blood sugar level during the perioperation of bone fracture patients with type 2 diabetes(T2DM).Methods Bone fracture patients with T2DM were randomly divided into three groups:continuous subcutaneous insulin infusion group(insulin aspart,group CSII,n=20),glargine treatment group(insulin aspart+insulin glargine,group GA,n=20),and NPH treatment(insulin aspart+rh-insulin,group NA,n=20).The levels of fasting plasma glucose(FPG)and the 2 hours postprandial glucose(2h PG),blood glucose fluctuation(BGF),insulin dosage(ID),good effective time(GET),incidence of hypoglycemia,dawn phenomenon and infection,average time of stitches removal(ATSR),average hospitalized length(AHL)of three groups were compared.Results FPG and 2hPG,ID in group CSII[(6.32±1.18)mmol/L,(7.72±1.53)mmol/L,(35.40±1.60)IU]and group GA [(6.25±0.88)mmol/L,(7.32±1.17)mmol/L,(36.20±0.80)IU]were significantly lower than those of group NA [(7.44±1.36)mmol/L,(8.52±0.76)mmol/L,(40.50±2.40)IU,all P<0.05],simulaneously,BGF,GET incidence of complications,ATSR,AHL of group CSII and GA were significantly lower than those of group NA(all P<0.05).There were not significant difference between group CSII and group GA.Compared with group CSII,group GA had less costs in-hospital and better practicability.Conclusion Both CSII and insulin glargine combined with insulin aspart can effectively,safely,rapidly and stablely control hyperglycemia.and might be the first choice to control blood sugar for bone fracture patients with T2DM in perioperation.     

遗传因素对糖耐量异常人群高血压的影响

分析６５２例糖耐量异常人群高血压发病的危险因素，结果显示伴高血压压病家族史者高血压的患病率显著高于不伴高血压病家族史。多因素Ｌｏｇｉｓｔｉｃ逐步回归分析表明，阳性高血压病家族史是本组人群最重要的致高血压病危险因素（ＯＲ１１７．２，９５％ＣＩ６８．１－２０１．６）。年体重指数和尿微量白蛋白与高血压呈显著正相关。提示在高血压防治对对伴高血压病家族史的糖耐量异常人群应予以特别的注意，而着意减肥和更严格地     

戒烟与生活习惯病的预防

人类生活习惯、方式与行为对疾病、健康、寿命影响很大。吸烟、酗酒、饮食无度、好逸恶劳、起居无节等不良生活习惯、生活方式及行为是一种”自我危险”。众所周知 ,吸烟严重影响健康。公元前 ,印第安人以吸烟来作为对太阳崇拜会议仪式上的应用 ,而今 ,被世界卫生组织 (ＷＨＯ)