Spexin与脂代谢相关性的研究进展

Spexin又称神经肽Q (neuropeptide Q, NPQ),是一种新型内源性神经肽,广泛表达于人、啮齿动物、鱼类等的中枢神经系统和外周组织中。近年来,人们逐渐认识到Spexin在调节摄食行为、脂代谢、减轻体重等方面发挥着重要的作用。Spexin与肥胖的发病相关,本文就Spexin与脂代谢相关性的研究做一综述,旨在为改善及治疗肥胖提供新方向。     

男性2型糖尿病合并代谢相关脂肪性肝病患者单核细胞/高密度脂蛋白胆固醇比值与胰岛素抵抗的相关性

Objective To explore the correlation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and insulin resistance (IR) in male patients with type 2 diabetes mellitus (T2DM) combined with metabolic-related fatty liver disease (MAFLD). Methods A total of 454 male patients with T2DM combined with MAFLD in National Metabolic Management Center (MMC) of the Affiliated Hospital of Jiangsu University from May 2018 to July 2020 were enrolled. The general clinical data of subjects were collected, blood routine and biochemical indexes were tested, homeostasis model insulin resistance index (HOMA-IR) was calculated, visceral fat area (VFA) and subcutaneous fat area (SFA) were measured. Accordingtothe MHR quartile, patients were divided into group Q1 (MHR≤0.38), group Q2 (0.380.64) to compare the differences in measured indicators above. In addition, patients were divided into two groups according to HOMA-IR, HOMA-IR<2.5 and HOMA-IR≥2.5, and the differences in MHR were compared. Results The patients were divided into four groups according to MHR:group Q1 (n=115), group Q2 (n=110), group Q3 (n=120) and group Q4 (n=109). Fasting insulin (FINS) were respectively 6.17(4.20,9.76), 7.73(4.94,10.66), 8.92(5.32,11.33) and 9.13(5.25,12.27) mU/L, 2-hour postprandial insulin were 22.75(12.87,39.59), 27.55(16.44,39.77), 30.98(17.46,43.11) and 31.28(18.54, 45.92) U / L. HOMA-IR were 3.12(1.63, 4.25), 3.72(2.26, 4.66), 3.87(2.48, 5.44) and 3.95(2.42, 5.31). Neutrophil (Neu) were 3.10(2.60,3.70), 3.20(2.50,3.93), 3.60(2.80,4.28), 4.20(3.30,5.00)×109/L. Subcutaneous fat area (SFA) were (181.27± 53.60), (192.64 ± 62.41), (199.53 ± 61.40) and (203.69 ± 71.51) cm2. They all increased gradually. However, the levels of high-density lipoprotein cholesterol (HDL-c) [1.18(1.06, 1.35), 1.02(0.86, 1.17), 0.96(0.80, 1.03) and 0.80(0.69, 0.92) mmol / L] and low-density lipoprotein cholesterol (LDL-c) [(3.00 ± 0.79), (2.76 ± 0.83), (2.67 ± 0.85) and (2.59 ± 0.92) mmol / L] decreased gradually. Pearson's or Spearman's correlation analysis showed that MHR was positively correlated with FINS, 2-hour postprandial insulin (2hINS), HOMA-IR, VFA and SFA (r=0.190, 0.153, 0.184, 0.114, 0.127, P<0.05). The coronary heart disease history, systolic blood pressure, diastolic blood pressure, fasting plasmaglucose (FPG), FINS, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood uric acid (Ur), body mass index (BMI), VFA, SFA and MHR of patients in group HOMA-IR≥2.5 were higher than group HOMA-IR<2.5 (P<0.05). Conclusion MHR is positively correlated with IR in male patients with T2DM combined with MAFLD, and as MHR increases, the degree of IR is higher. © 2023 China Tropical Medicine. All rights reserved.