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Ratanachu-ek T Prajanphanit P Leelawat K Chantawibul S Panpimanmas S Subwongcharoen S Wannaprasert J 《World journal of gastroenterology : WJG》2007,13(2):276-279
AIM To determine the role of ciprofloxacin in reducing cholangitis in cholestatic patients with adequate biliary drainage after endoscopic retrograde cholangiopancreatography (ERCP).METHODS A randomized, controlled trial was performed in 48 cholestatic patients at Rajavithi Hospital (Tertiary Referral Center for ERCP 600 cases per year). All the 48 patients received 200 mg ciprofloxacin intravenous injection for 30 min before starting any procedures, and then were randomly divided in two groups. Twenty-two patients in study group continually received ciprofloxacin until 48 h after ERCP. Causes of biliary obstruction, bacteriology of bile and blood (in cholangitis) and clinical cholangitis were recorded.RESULTS Forty-eight patients were enrolled and divided into continuous ciprofloxacin treatment group (n = 22) and discontinuous ciprofloxacin treatment group (n = 26). During ERCP, stones were found in 22 patients,malignant diseases in 24 patients and other pathologic lesions in 5 patients. One (4.5%) of the 22 patients who received ciprofloxacin and 2 (6.3%) of the 26 patients who discontinued ciprofloxacin after ERCP developed cholangitis (relative risk = 0.71; 95% CI = 0.14-3.65;P = 0.88). Bacterobilia was found in 27 (56.3%) out of 48 patients. E. coli and Streptococcus viridans were the most common organisms.CONCLUSION Continual use of ciprofloxacin in patients with cholestasis after adequate biliary drainage procedures plays no role in reducing cholangitis. 相似文献
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Drug Safety - Published reviews of written medicine information (WMI) have mainly drawn on studies published in high-income countries, including very few Asian or African studies. We therefore set... 相似文献
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Mungkornasawakul P Pyne SG Jatisatienr A Lie W Ung AT Issakul K Sawatwanich A Supyen D Jatisatienr C 《Journal of natural products》2004,67(10):1740-1743
Two new dihydrostemofoline alkaloids, 11(S),12(R)-dihydrostemofoline (3) and stemoburkilline (4), along with stemofoline (1) and 2'-hydroxystemofoline (2) have been isolated from a root extract of Stemona burkillii Prain. The structure and relative configuration of 3 have been determined via spectroscopic data and from comparison with synthetic 11(S),12(S)-dihydrostemofoline (5). The configuration of the exo-cyclic alkene group in 4 is tentively assigned as E on the basis of mechanistic considerations. 相似文献
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Euphemia L Sibanda Marc d'Elbe Galven Maringwa Nancy Ruhode Mary Tumushime Claudius Madanhire Jason J Ong Pitchaya Indravudh Constancia Watadzaushe Cheryl C Johnson Karin Hatzold Miriam Taegtmeyer James R Hargreaves Elizabeth L Corbett Frances M Cowan Fern Terris‐Prestholt 《Journal of the International AIDS Society》2019,22(Z1)
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Collin Mangenah Lawrence Mwenge Linda Sande Nurilign Ahmed Marc d'Elbe Progress Chiwawa Tariro Chigwenah Sarah Kanema Miriam N Mutseta Mutinta Nalubamba Richard Chilongosi Pitchaya Indravudh Euphemia L Sibanda Melissa Neuman Getrude Ncube Jason J Ong Owen Mugurungi Karin Hatzold Cheryl C Johnson Helen Ayles Elizabeth L Corbett Frances M Cowan Hendramoorthy Maheswaran Fern Terris‐Prestholt 《Journal of the International AIDS Society》2019,22(Z1)
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Pitchaya Dilokpattanamongkol Viratch Tangsujaritvijit Thanarat Suansanae Chuthamanee Suthisisang 《International journal of clinical pharmacy》2017,39(3):573-581
Background Currently, a lack of pharmaceutical care exists concerning pain and agitation in medical intensive care units (MICU) in Thailand. Pharmaceutical care focusing on analgesics/sedatives would improve clinical outcomes. Objective To investigate the impact of pharmaceutical care of pain and agitation on ICU length of stay (LOS), hospital LOS, ventilator days and mortality. Setting The MICU of a university hospital. Method A before/after study was conducted on mechanically ventilated patients receiving analgesics/sedatives. Medical chart reviews and data collection were conducted in the retrospective group (no pharmacists involved). In the prospective group, pharmacists involved with the critical care team helped select analgesics/sedatives for individual patients. Main outcome measure ICU LOS Results In total, 90 and 66 patients were enrolled in retrospective and prospective groups, respectively. The median duration of ICU LOS was reduced from 10.00 (2.00–72.00) in the retrospective group to 6.50 days (2.00–30.00) in the prospective group (p = 0.002). The median hospital stay was reduced from 30.50 days (2.00–119.00) in the retrospective group to 17.50 days (2.00–110.00) in the prospective group (p < 0.001). Also, the median ventilator days was reduced from 14.00 days (2.00–90.00) to 8.50 days (1.00–45.00), p = 0.008. Mortality was 53.03% in the prospective group and 46.67% in the retrospective group (p = 0.432). Conclusion Pharmacist participation in a critical care team resulted in a significant reduction in the duration of ICU LOS, hospital LOS and ventilator days, but not mortality. 相似文献
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Mungkornasawakul P Pyne SG Jatisatienr A Supyen D Lie W Ung AT Skelton BW White AH 《Journal of natural products》2003,66(7):980-982
A new pentacyclic stemona alkaloid, stemocurtisine (2), with a novel pyrido[1,2-a]azapine A,B-ring system, has been isolated from a root extract of Stemona curtisii. The structure and relative stereochemistry was determined by spectral data interpretation and X-ray crystallography. 相似文献