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排序方式: 共有224条查询结果,搜索用时 15 毫秒
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Michels Guido Horn Rudolf Helfen Andreas Hagendorff Andreas Jung Christian Hoffmann Beatrice Jaspers Natalie Kinkel Horst Greim Clemens-Alexander Knebel Fabian Bauersachs Johann Busch Hans-Jörg Kiefl Daniel Spiel Alexander O. Marx Gernot Dietrich Christoph F. 《Der Anaesthesist》2022,71(4):307-310
Die Anaesthesiologie - 相似文献
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H Suttmann U Rampf G Juhl M Greim A Doenicke 《EEG-EMG Zeitschrift für Elektroenzephalographie, Elektromyographie und verwandte Gebiete》1990,21(1):20-28
In a prospective randomized study involving 32 male subjects aged 18 to 38, the effects of flunitrazepam (0.25 to 2 mg/70 kg), lormetazepam (0.5 to 4 mg/70 kg), midazolam (1.5 to 12 mg/70 kg) and diazepam (4 to 32 mg/70 kg) on the beta-activity (13 to 20/s) were investigated. Each subject received four benzodiazepine injections of increasing dosage. The doses were selected so that the lowest had only a slight effect on the test person's condition, while the highest resulted in deep sedation. The increase in beta-activity started off with a latency of 30 to 60 s; it was proportional to the dosage and reached its maximum between the 2. and 3. minutes. The subsequent decrease in beta-activity could be represented by an exponential function. The effect could be cancelled temporarily by administering repeated doses of the specific antagonist, flumazenil (0.1, 0.3 and 0.9 mg/70 kg). The method is suited for describing pharmacodynamic processes, determining equipotential doses of benzodiazepines and detecting the interaction between benzodiazepines and specific antagonists. 相似文献
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C.-A. Greim N. Roewer C. Apfel G. Laux J. Schulte am Esch 《Intensive care medicine》1997,23(4):411-416
Objective: To examine the usefulness of preload indices obtained by transoesophageal echocardiography (TOE) for estimating stroke volume
at various levels of cardiac index. Design: Prospective clinical study. Setting: Intensive care unit with surgical patients. Patients: 16 ventilated patients monitored via Swan-Ganz catheterization and TOE. Interventions: Echocardiographic images of left ventricular cross-sectional short-axis areas were analysed for the preload indices end-diastolic
area (EDA), stroke area and end-diastolic wall stress. The relation between these indices and stroke volume, calculated from
thermodilution cardiac output, was analysed in all patients and in nine patient groups discriminated by various ranges in
heart rate (≤ 70 to > 110 beats/min), pulmonary artery occlusion pressure (≤ 8 to > 12 mm Hg) and cardiac index (≤ 3.0 to
> 4.2 l/min per m2). Measurements and results: Overall stroke volume (n = 155) correlated significantly (p < 0.0001) with EDA (r = 0.89) and stroke area (r = 0.80). The correlation with end-diastolic wall stress was non-significant (r = 0.51). Linearity in the relation between stroke volume and EDA or stroke area was independent of variations in heart rate
and pulmonary artery occlusion pressure. Stroke volume correlated well with EDA and stroke area, when cardiac index was normal
or high, but the relation slightly deteriorated (r = 0.63 to ≤ 0.72) when the cardiac index was low. Changes in EDA and stroke area by more than 1, 2 or 3 cm2 were weak predictors for changes in stroke volume greater than 20 %. Conclusions: Stability of the relation between echocardiographic preload indices and stroke volume emphasize the potential of TOE for
continuous preload monitoring in the critically ill.
Received: 11 April 1996 Accepted: 2 January 1997 相似文献
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H J Hagel R L Mueller U Schoenherr G Greim H Ruppin W Domschke 《Zeitschrift für Gastroenterologie》1985,23(4):169-174
Gastric bacterial overgrowth was studied in 8 healthy volunteers. Total bacterial counts, nitrate-reducing bacteria and nitrite concentration were determined in fasting gastric juice before and after 4 weeks of treatment with a strong or with a mild antacid drug, a placebo preparation and the spasmolytic agent papaverine which is known to inhibit gastric evacuation. Placebo therapy and the mild antacid did not change any of the above parameters studied. The strong antacid caused a significant increase in the pH of gastric contents which was accompanied by an enormous increase in total bacterial counts, nitrate-reducing bacteria and nitrite concentration. Papaverine which did not cause a significant elevation of pH also definitely increased bacterial counts and nitrite concentration of gastric juice. Four weeks following termination of each treatment procedure, however, all changes outlined above had returned to pretreatment values. These results indicate that reversible gastric bacterial overgrowth under therapeutical conditions may occur when acidity of the stomach is reduced or gastric evacuation is retarded. 相似文献
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Journal of Neurology - Fatigue is a widespread symptom in numerous neuroimmunological diseases like multiple sclerosis (MS), myasthenia gravis, morbus Behcet, neurosarcoidosis, neuroborreliosis or... 相似文献
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