排序方式: 共有77条查询结果,搜索用时 15 毫秒
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Alkomiet Hasan Peter Falkai Thomas Wobrock Jeffrey Lieberman Birte Glenthøj Wagner F. Gattaz 《The world journal of biological psychiatry》2015,16(3):142-170
These updated guidelines are based on the first edition of the World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia published in the years 2005 and 2006. For this 2015 revision, all available publications pertaining to the biological treatment of schizophrenia were reviewed systematically to allow for an evidence-based update. These guidelines provide evidence-based practice recommendations which are clinically and scientifically relevant. They are intended to be used by all physicians diagnosing and treating patients with schizophrenia. Based on the first version of these guidelines a systematic review, as well as a data extraction from national guidelines have been performed for this update. The identified literature was evaluated with respect to the strength of evidence for its efficacy and subsequently categorised into six levels of evidence (A–F) and five levels of recommendation (1–5). This third part of the updated guidelines covers the management of the following specific treatment circumstances: comorbid depression, suicidality, various comorbid substance use disorders (legal and illegal drugs), and pregnancy and lactation. These guidelines are primarily concerned with the biological treatment (including antipsychotic medication and other pharmacological treatment options) of patients with schizophrenia. 相似文献
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Yamada Shinichi Takahashi Shun Malchow Berend Papazova Irina Stöcklein Sophia Ertl-Wagner Birgit Papazov Boris Kumpf Ulrike Wobrock Thomas Keller-Varady Katriona Hasan Alkomiet Falkai Peter Wagner Elias Raabe Florian J. Keeser Daniel 《European archives of psychiatry and clinical neuroscience》2022,272(6):957-969
European Archives of Psychiatry and Clinical Neuroscience - Significant evidence links white matter (WM) microstructural abnormalities to cognitive impairment in schizophrenia (SZ), but the... 相似文献
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Daniel Martins-de-Souza Giuseppina Maccarrone Thomas Wobrock Inga Zerr Philipp Gormanns Stefan Reckow Peter Falkai Andrea Schmitt Christoph W. Turck 《Journal of psychiatric research》2010,44(16):1176-1189
Schizophrenia (SCZ) is the result of DNA alterations and environmental factors, which together lead to differential protein expression and ultimately to the development of the illness. The diagnosis is based on clinical symptoms, and the molecular background of SCZ is not completely understood. The thalamus, whose dysfunction has been associated with SCZ based in diverse lines of evidences, plays for instance a pivotal role in the central nervous system as a relay center by re-distributing auditory and visual stimuli from diverse brain regions to the cerebral cortex. We analyzed the proteome of postmortem mediodorsal thalamus (MDT) samples from 11 SCZ patients and 8 non-SCZ individuals by using quantitative shotgun-mass spectrometry and two-dimensional gel electrophoresis. Our analyses identified 551 proteins, 50 of which showed significant differential expression. The main pathways affected by the differentially expressed proteins include energy metabolism, oligodendrocyte metabolism, and cytoskeleton assembly. The potential protein biomarkers candidates myelin basic protein and myelin oligodendrocyte protein were validated by Western blot in the MDT samples and also in cerebrospinal fluid from a separate set of samples of 17 first-episode SCZ patients and 10 healthy controls. The differential expression of μ-crystallin, protein kinase C-gamma, and glial fibrillary acidic protein were confirmed in MDT. Because we found several glycolysis enzymes to be differentially expressed, we measured the levels of pyruvate and NADPH and found them to be altered in MDT. The protein changes described here corroborate the importance of myelin/oligodendrocyte and energy metabolism in SCZ and highlight new potential biomarkers candidates that may contribute to the understanding of the pathogenesis of this complex disease. 相似文献
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Alkomiet Hasan Lisa KremerOliver Gruber Thomas Schneider-AxmannBirgit Guse Wolfgang ReithPeter Falkai Thomas Wobrock 《Psychiatry Research: Neuroimaging》2011,193(1):56-59
In schizophrenia patients reduced cerebral asymmetry is an important finding and this may reflect a disturbance in cortical development. We investigated planum temporale (PT) volume and asymmetry in 23 first-episode schizophrenia patients compared to healthy controls and found for the first time an in vivo volume asymmetry of PT to the right hemisphere. 相似文献
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A 63-year-old male patient diagnosed with chronic schizophrenia and characterized by formal disorders of thought with neologism and paranoid ideation, especially grandiose delusions and feelings of being influenced by radiation, is presented. At admission to psychiatric hospital, the patient reported attacks of weakness and dizziness, which he attributed to his feelings of alien influence. The diagnosis of cardiac disease with severe bradycardia could already be established by basic physical examination. Further diagnostic procedures (e.g., ECG) revealed symptomatic atrioventricular conduction defects (atrioventricular block III). After implantation of a cardiac pacemaker, the somatic symptoms vanished and the patient recovered completely in terms of physical condition. 相似文献
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Liz Rietschel Martin Lambert Anne Karow Mathias Zink Hendrik Müller Andreas Heinz Walter de Millas Birgit Janssen Wolfgang Gaebel Frank Schneider Dieter Naber Georg Juckel Seza Krüger‐Özgürdal Thomas Wobrock Michael Wagner Wolfgang Maier Joachim Klosterkötter Andreas Bechdolf PREVENT study group 《Early intervention in psychiatry》2017,11(4):306-313