电生理检测对贝耳麻痹患者的预后评估

INTRODUCTIONBellpalsyisoneofthemostcommondiseasesinneurologicalde－partment．HowtopredicttheprognosisofBellpalsyiswhatdoctorsandpatientsareconcernedabout．MATERIALSANDMETHODSMaterialsClinicalmaterialswerecollectedfromFebruary１９９６toDecember２０００．４２caseswereselectedfrom１０６casesofBellpalsywhosemanifestationsandelectrophysiologicaltestwerefollowedupcontinuously．Patientssex：２２menand２０women；Agerang：１８－７４yearsold，averageage：３８yearsold；Thefirsttestingtimew…     

Electrophsiological study in the prognosis of Bell palsy

AIM:To estimate the prognosis of Bell palsy,METHODS:Blink relex (BR),electromyography(EMG),motor latency(ML) and amplitude (AMP) of facial nerve were performed in 42 patients with Bell‘‘‘‘s palsy.The patients were followed about half a year.RESULTS:(1) When 1 of the 3R waves related with the ill side existed or appeared in 3 weeks after onset,97% patients could recover completely.THe recovery time was realted to the time of the occurrence of R wave.(2) When 1 of the 3R waves appeared in the 4th week.60% patients could recover completely,When none of the 3 wasves appeared after the 4th week,100% patients could not recover completely.EMG showed spontaneous activities in 3 of the 6 patients in the 4th week.(3) Motor latency and amplitude of facial nerve were examined when the illness stopped developing.All patients had normal lalencies,5 patinets‘‘‘‘ amplitudes reduced more than 90%.3 of the 5 patients did not appear the related R waves after the 4th week.CONCLUSION:BR might provide the early sign of good prognosis of Bell‘‘‘‘s palsy ,BR together with EMG and ML and AMP of facial nerve might provide the later sign of poor prognosis.     

B样条小波在提取脑电癫痫棘波中的应用

脑电癫痫特征波自动提取对于患者的诊断，以及减轻医生的繁重劳动力都具有重要意义。采用B样条小波对信号突变点灵敏检测的优良特性来进行癫痫棘波提取，取得了比较好的效果。     

Study of repeated nerve stimulation in myasthenia gravis

AMI：To investigate normal value range of low-frequent repeated nerve stimulation (RNS): whether different low-frequent stimulation and different muscles have different normal value rang.METHODS:Low-frequent(3c/s and 5c/s) RNS of 30 healthy people and 27 myasthenia gravis (MG) patients were rest. RESULTS:Superior limit of amplitude of wave attenuation value of low-frequent RNS(x^-&;#177;2.5s) of different muscles (orbicularis oculi muscle, deltoid muscle and abductor muscle of little finger) of healthy people was 5.45%-7.55%. According to our normal value standard, RNS positive rate of MG group was 85%; according to the current criteria (amplitude of wave attenuation value&;gt;10%), positive rate of MG group was 70%, there was no apparent difference in RNS positive rate (P&;gt;0.1). Some labs adopted the criteria that amplitude of wave attenuation value&;gt;15%, according to this criteria, positive rate of MG group was 51%. Compared with positive rate (85%) obtained according to our criteria, there was apparent difference(P&;lt;0.01).CONCLUSION:Each labs should establish their own normal value standard according to difference muscle and different frequent. If adopt universal standard,amplitude of wave attenuation value 8% or 10% was suggested.     

环氧合酶-2和磷酸化P38丝裂原活化蛋白激酶在扁平苔藓皮损中的表达

目的：检测环氧合酶-2（COX-2）及其上游调控蛋白磷酸化P38丝裂原活化蛋白激酶（p-P38MAPK）在扁平苔藓皮损中的表达，探讨其在发病中的意义。方法：采用免疫组化技术检测20例扁平苔藓皮损标本中COX-2和p-P38MAPK的表达情况，20例正常皮肤组织作为对照。结果：20例扁平苔藓皮损标本中COX-2和p-P38MAPK的积分光密度值（IOD）分别为（8.46±1.79）×10³和（11.54±2.85）×103，均明显高于对照组(3.14±2.35)×103和(6.26±3.12)×10³，差别具有统计学意义（均P＜0.01），同时COX-2与p-P38MAPK的表达强度呈正相关（r=0.62，P＜0.01）。结论：扁平苔藓皮损中COX-2表达上调，可能与上游P38MAPK的活化有关，可能是引起扁平苔藓发病的环节之一。     

椎－基底动脉TIA的BAEP转颈试验研究

本文对５０例椎－基底动脉－过性脑缺血发作（ＶＢ·ＴＩＡ）患者于发作间歇期进行了脑干听觉诱发电位（ＢＡＥＰ）转颈试验的研究。结果表明：ＢＡＥＰ转颈试验后，ＶＢ·ＴＩＡ患者的ＢＡＥＰ异常率，由转颈前的４８％显著地增高到８０％（Ｐ＜０．００５）。其ＢＡＥＰ异常主要表现为ＰＬⅠ、ＰＬⅤ、ＩＰＬⅢ～Ⅴ的延长。相比之下，对照组转颈前后ＢＡＥＰ变化无显著性（Ｐ＞０．０５）。由此提示血液动力学因素在本病的发病机制中起着极为重要的作用。     

椎—基底动脉TIA的BAEP转颈试验研究

本文对５０例椎－基底动脉－过性脑缺血发作患者于发作间歇期进行了脑干听觉诱发电位转颈试验的研究。结果表明：ＢＡＥＰ转颈试验后，ＶＢ．ＴＩＡ患者的ＢＡＥＰ异常率，由转颈前的４８％显著地增到８０％。其ＢＡＥＰ异常主要表现为ＰＬ１、ＰＬＶ、ＩＰＬⅢ－Ⅴ的延长。相比之下，对照组转颈前后ＢＡＥＰ变化无显著性。由此提示血液动力学因素在本病的发病机制中起着极为重要的作用。     

一种基于EEG特征提取的癫痫棘波综合检测判决方法

癫痫特征的自动检测在临床应用上具有重要的意义。本研究综合小波变换、非线性能量算子、特征提取和神经网络等技术，提出了一种癫痫棘波检测系统，充分发挥各技术的优点，在对真实脑电数据的处理中，表现出良好的性能。     

基于EEG信号AR模型的中枢神经系统损伤检测

本文综述一类基于 EEG信号 AR谱和 AR模型参数分析的中枢神经系统损伤检测方法 ,包括主控频率法、AR谱距离法和 Itakura距离测度法等。这类方法根据 EEG信号的 AR模型建立分析 EEG信号状态和变化的测度 ,并利用其检测中枢神经系统在缺氧窒息实验过程中可能存在的损伤并预测最终结果。实验和数据分析的结果表明 ,这类方法在实验各个阶段的检测结果与采用医学方法进行综合评价的 NDS结果一致 ,具有较高的可靠性。