维胺脂胶囊(三蕊)治疗痤疮和脂溢性皮炎临床疗效观察

笔者所在科室于2001年3月起采用维胺脂胶囊(商品名:三蕊,重庆华邦制药有限公司)治疗痤疮和脂溢性皮炎,获得良好的效果,现报告如下。1临床资料病例:将50例门诊就诊的痤疮及脂溢性皮炎患者分为两组,痤疮组患者30例,男10例,女20例,年龄14～40岁,病期3个月～10年,平均病期(3.5±1.4)年。脂溢性皮炎组患者20例,男10例,女10例,年龄22～40岁,病期1～10年,平均病期(3.6±1.5)年。所有患者治疗前均未服用过皮质类固醇、维A酸类药物,育龄期妇女在服药期间和停药后的半年内均采取避孕措施,孕妇及有高血脂、肝肾功能异常者均不列入观察。2治疗及观察方…     

头孢克罗治疗单纯性淋菌性尿道炎40例临床疗效分析

我科于1995年4月至10月以头孢克罗治疗单纯性淋菌性尿道炎40例,取得满意效果,现于报道.1 材料与方法1.1 临床资料 40例均为我科性病门诊确诊患者.男32例,女8例.年龄最大50a,最小21a,平均31±1a.病期1d～2wk.所有患者均有性乱史或配偶感染史.32例男性患者均有不同程度的尿道流脓和尿路刺激症状,检查可见尿道口红肿,部分患者有包皮或龟头红肿;8例女性患者中,3例自觉外阴部分泌物多,5例无自觉症状(作为性侣来院检查时发现),体检见阴道内有污秽样分泌物,宫颈口有Ⅱ～Ⅲ°不等的糜烂.     

氯雷他定（分散片）治疗慢性荨麻疹的临床试验观察

目的：观察氯雷他定(分散片)治疗慢性荨麻疹的疗效及安全性。方法：每日一次口服氯雷他定(分散片)10mg，连续用药2周。结果：1周有效率40％，2周有效率87．5％。结论：氯雷他定(分散片)治疗慢性荨麻疹的疗效明确，副作用少，安全性。     

梅毒非特异性类脂质反应素抗体试验操作的改进及应用评价

Objective To estimate the application value of a standard operating procedure (SOP) in the detection of syphilitic anticardiolipin reagin. Methods Clinical laboratories from 9 local hospitals in Shanghai participated the program. Quality control samples with unknown target value were qualitatively and quantitatively examined according to the uniform SOP in these laboratories with the same reagent and facility of horizontal reaction. External quality assessment (EQA) was carried out by using seven serum samples with no, or low (1∶ 128 dilution) to high (1∶1 dilution) concentrations of target before and after the implementation of SOP. The test results were statistically analyzed and the reasons for the detecting error were assessed. Results A total of 388 tests were performed in the 9 clinical laboratories. The total accuracy rate was 93.0%, including 40.2% in the detection of samples with 1 ∶ 8 dilution of target, 49.2% in the detection of samples with 1 ∶ 16 dilution of target, and 3.6% in the detection of samples with 1 ∶ 32 dilution of target. No forward bias was observed in these tests. There was a significant difference in the accuracy rate between the two times of EQA before and after the implementation of SOP (x2 = 4.17, P < 0.05). Conclusions The improved standard procedure for nontreponemal antigen test is beneficial to the decrease of testing error, and may provide a basis for the establishment of SOP and implementation of internal quality assessment.     

银屑病患者的抑郁情绪和生活质量调查

目的探讨银屑病患者抑郁情绪发生情况及对生活质量的影响。方法选取门诊寻常型银屑病患者102例,采用抑郁自评量表中SDS、抑郁他评量表中HAMD和皮肤病患者生活质量问卷(DLQI)进行测评分析。结果①以HAMD和SDS两种量表测定抑郁情绪的发生率分别为44.12%(45/102例)和41.18%(42/102例),其中重度抑郁的发生率,HAMD法为9.8%(10/102例),SDS法为8.82%(9/102例);②DLQI评分在3～27分间,平均17.8分,以心理、穿衣、社交娱乐等几项得分最高;③女性较男性、40岁以下较40岁以上患者HAMD、SDS、DLQI分值均高,有显著性差异(P<0.01)。结论较多数银屑病患者存在抑郁情绪,严重影响着患者社交、情绪、睡眠等各个方面生活质量问题,提示对银屑病患者应加强心理干预。     

半导体激光治疗中度及重度痤疮的临床疗效

目的 探索波长650、810 nm的半导体激光治疗中、重度痤疮的临床疗效及安全性.方法 将87例面部痤疮患者,分为激光治疗组(A组)和药物治疗组(B组).A组:用波长650、810 nm半导体激光连续输出功率400～450 mW,非接触性照射(距离为2～3 cm),10 min/次,1次/d,共2周;然后,隔日1次,共2周,16次;B组:口服罗红霉素胶囊0.15g,2次/d,共4周,配合口服维生素B6,外用绿药膏治疗.治疗前及治疗后每周进行临床疗效观察,数码拍照以备对比分析,并在治疗结束后,随访4个月.同时,记录治疗过程中出现的不良反应.结果 A组和B组疗效在治疗后2周(65.0％比42.6％,P＞0.05)、4周(92.5％比76.5％,P＞0.05)差异无统计学意义,但A组复发率显著低于B组,差异有统计学意义(30.0％比61.7％,P＜0.01).结论 与药物治疗相比,半导体激光治疗中、重度痤疮可显著降低其复发率.     

上海市性病患者对性病咨询服务需求的调查

目的　了解性病患者对性病咨询服务的需求情况。方法　对上海市 4家医院性病门诊的性病患者进行问卷调查。结果　①多数性病患者希望在独立的咨询门诊 (5 2 5 % )和看病过程中 (5 0 8% )获得咨询服务 ;②84 9%的性病患者认为咨询服务应在只有医生和病人的两人诊室中进行 ;③ 6 2 1%的性病患者赞同性病咨询服务收费 ,其态度与收入水平有关 ,收入越高赞同的比例越高 ;④ 6 6 4 %的性病患者希望咨询的医生就是看病时的首诊医生 ;⑤男性和女性性病患者咨询的侧重存在差异 ,男性患者更关心有危险行为时的预防措施 (47 9% ) ,而女性患者更关注性病的预后情况 (6 6 4 % )。结论　咨询人员应从性病患者的需求出发 ,为他们提供最需要的服务     

梅毒非特异性类脂质反应素抗体试验操作的改进及应用评价

Objective To estimate the application value of a standard operating procedure (SOP) in the detection of syphilitic anticardiolipin reagin. Methods Clinical laboratories from 9 local hospitals in Shanghai participated the program. Quality control samples with unknown target value were qualitatively and quantitatively examined according to the uniform SOP in these laboratories with the same reagent and facility of horizontal reaction. External quality assessment (EQA) was carried out by using seven serum samples with no, or low (1∶ 128 dilution) to high (1∶1 dilution) concentrations of target before and after the implementation of SOP. The test results were statistically analyzed and the reasons for the detecting error were assessed. Results A total of 388 tests were performed in the 9 clinical laboratories. The total accuracy rate was 93.0%, including 40.2% in the detection of samples with 1 ∶ 8 dilution of target, 49.2% in the detection of samples with 1 ∶ 16 dilution of target, and 3.6% in the detection of samples with 1 ∶ 32 dilution of target. No forward bias was observed in these tests. There was a significant difference in the accuracy rate between the two times of EQA before and after the implementation of SOP (x2 = 4.17, P < 0.05). Conclusions The improved standard procedure for nontreponemal antigen test is beneficial to the decrease of testing error, and may provide a basis for the establishment of SOP and implementation of internal quality assessment.     

Kindler综合征

报告1例Kindler综合征.患者男,54 岁.全身反复发生水疱、色素异常伴皮肤萎缩、手足角化性斑块6 年.面部及手部皮损日晒后加重,无明显自觉症状.患者出生和幼年时,无类似皮损发生.     

不同人群支原体感染情况及药物疗效观察

支原体感染作为一种性传染疾病近几年来发病率有上升趋势,特别是有不洁性生活史的青壮年发病率高,而且发病后可引起非特异性尿道炎等,还可能引起不孕和不育。我们通过对不同人群支原体感染情况及药物疗效观察,来阐述“支原体感染”者和“性伴数”之间可能存在的关系及阿齐霉素、强力霉素、美满霉素治疗“支原体感染”患者的有效率。