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排序方式: 共有209条查询结果,搜索用时 93 毫秒
1.
Jansa P Becvar R Ambroz D Palecek T Tomcik M Skacelova S Aschermann M Linhart A 《Clinical rheumatology》2012,31(3):557-561
Background
Systemic sclerosis (SSc) is an important cause of pulmonary arterial hypertension (PAH), with an estimated prevalence of 7.85–26.7%. 相似文献2.
Tekgül S Riedmiller H Hoebeke P Kočvara R Nijman RJ Radmayr C Stein R Dogan HS 《European urology》2012,62(3):534-542
Context
Primary vesicoureteral reflux (VUR) is a common congenital urinary tract abnormality in children. There is considerable controversy regarding its management. Preservation of kidney function is the main goal of treatment, which necessitates identification of patients requiring early intervention.Objective
To present a management approach for VUR based on early risk assessment.Evidence acquisition
A literature search was performed and the data reviewed. From selected papers, data were extracted and analyzed with a focus on risk stratification. The authors recognize that there are limited high-level data on which to base unequivocal recommendations, necessitating a revisiting of this topic in the years to come.Evidence synthesis
There is no consensus on the optimal management of VUR or on its diagnostic procedures, treatment options, or most effective timing of treatment. By defining risk factors (family history, gender, laterality, age at presentation, presenting symptoms, VUR grade, duplication, and other voiding dysfunctions), early stratification should allow identification of patients at high potential risk of renal scarring and urinary tract infections (UTIs). Imaging is the basis for diagnosis and further management. Standard imaging tests comprise renal and bladder ultrasonography, voiding cystourethrography, and nuclear renal scanning. There is a well-documented link with lower urinary tract dysfunction (LUTD); patients with LUTD and febrile UTI are likely to present with VUR. Diagnosis can be confirmed through a video urodynamic study combined with a urodynamic investigation. Early screening of the siblings and offspring of reflux patients seems indicated.Conservative therapy includes watchful waiting, intermittent or continuous antibiotic prophylaxis, and bladder rehabilitation in patients with LUTD. The goal of the conservative approach is prevention of febrile UTI, since VUR will not damage the kidney when it is free of infection. Interventional therapies include injection of bulking agents and ureteral reimplantation. Reimplantation can be performed using a number of different surgical approaches, with a recent focus on minimally invasive techniques.Conclusions
While it is important to avoid overtreatment, finding a balance between cases with clinically insignificant VUR and cases that require immediate intervention should be the guiding principle in the management of children presenting with VUR. 相似文献3.
Radim Janousek Antonin Krajina Jan H. Peregrin Sylvie Dusilova-Sulkova Ondrej Renc Jan Hajek Kamil Dvorak Petr Fixa Eva Cermakova 《Cardiovascular and interventional radiology》2010,33(1):61-66
We evaluated the impact of intravascular iodinated contrast medium on residual diuresis in hemodialyzed patients. Two groups
of clinically stable hemodialyzed patients with residual diuresis minimally 500 ml of urine per day were studied. The patients
from the first group were given iso-osmolal contrast agent iodixanol (Visipaque, GE Healthcare, United Kingdom) in concentration
of iodine 320 mg/ml with osmolality 290 mOsm/kg of water during the endovascular procedure. The second control group was followed
without contrast medium administered. Residual diuresis and residual renal excretory capacity expressed as 24-h calculated
creatinine clearance were evaluated in the both groups after 6 months. The evaluated group included 42 patients who were given
99.3 ml of iodixanol in average (range, 60–180 ml). The control group included 45 patients. There was no statistically significant
difference found between both groups in daily volume of urine (P = 0.855) and calculated clearance of creatinine (P = 0.573). We can conclude that residual diuresis is not significantly influenced by intravascular administration of iso-osmolal
iodinated contrast agent (iodixanol) in range of volume from 60 to 180 ml in comparison to natural course of urinary output
and residual renal function during end-stage renal disease. This result can help the nephrologist to decide which imaging
method/contrast medium to use in dialyzed patients in current practice. 相似文献
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Petra Laššuthová Dana Šafka Brožková Jana Neupauerová Marcela Krůtová Radim Mazanec Pavel Seeman 《Neuromuscular disorders : NMD》2017,27(1):57-60
The association of GNB4 with Charcot–Marie–Tooth (CMT) has recently been described in a publication by Soong et al. (Soong, et al., 2013). Here we present a patient with CMT in whom whole exome sequencing identified the mutation p.Lys57Glu in the GNB4 gene (NM_021629.3:c.169A>G). The patient, now 41 years old, is a sporadic case in the family. At the age of 35 he presented with severe disability (CMT neuropathy score 29), profound muscle atrophies, pes cavus and scoliosis. Previously, the patient was tested for PMP22 duplications/deletions and later also with 64 CMT gene panel, with no causal variant found. Subsequently, whole exome sequencing was performed. The p.Lys57Glu in the GNB4 gene was identified as the most probable causal variant, the mutation is not present in the patient's parents, neither in his unaffected sister, therefore we assume that the mutation arose de novo. Taken together, these findings support the causal and pathogenic character of the variant. Our report provides important evidence that GNB4 should become an established CMT gene and our findings confirm the original publication by Soong et al. (2013). 相似文献
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Tristal steel is low-carbon construction-type steel widely used in the automotive industry, e.g., for braking components. Given the contemporary demands on the high-volume production of such components, these are typically fabricated using automatic sequential machines, which can produce components at strain rates up to 103 s−1. For this reason, characterising the behaviour of the used material at high strain rates is of the utmost importance for successful industrial production. This study focuses on the characterisation of the behaviour of low-carbon steel via developing its material model using the Johnson-Cook constitutive equation. At first, the Taylor anvil test is performed. Subsequently, the acquired data together with the results of observations of structures and properties of the tested specimens are used to fill the necessary parameters into the equation. Finally, the developed equation is used to numerically simulate the Taylor anvil test and the predicted data is correlated with the experimentally acquired one. The results showed a satisfactory correlation of the experimental and predicted data; the deformed specimen region featured increased occurrence of dislocations, as well as higher hardness (its original value of 88 HV increased to more than 200 HV after testing), which corresponded to the predicted distributions of effective imposed strain and compressive stress. 相似文献
8.
Michal Koínek Radim Halama Frantiek Fojtík Marek Pag
Jií Kr
ek David Krzikalla Radim Kocich Lenka Kun
ick 《Materials》2021,14(1)
The aim of this work was to monitor the mechanical behavior of 316L stainless steel produced by 3D printing in the vertical direction. The material was tested in the “as printed” state. Digital Image Correlation measurements were used for 4 types of notched specimens. The behavior of these specimens under monotonic loading was investigated in two loading paths: tension and torsion. Based on the experimental data, two yield criteria were used in the finite element analyses. Von Mises criterion and Hill criterion were applied, together with the nonlinear isotropic hardening rule of Voce. Subsequently, the load-deformation responses of simulations and experiments were compared. Results of the Hill criterion show better correlation with experimental data. The numerical study shows that taking into account the difference in yield stress in the horizontal direction of printing plays a crucial role for modeling of notched geometries loaded in the vertical direction of printing. Ductility of 3D printed specimens in the “as printed” state is also compared with 3D printed machined specimens and specimens produced by conventional methods. “As printed” specimens have 2/3 lower ductility than specimens produced by a conventional production method. Machining of “as printed” specimens does not affect the yield stress, but a significant reduction of ductility was observed due to microcracks arising from the pores as a microscopic surface study showed. 相似文献
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