全文获取类型
收费全文 | 1158283篇 |
免费 | 79089篇 |
国内免费 | 1802篇 |
专业分类
耳鼻咽喉 | 15964篇 |
儿科学 | 31286篇 |
妇产科学 | 28099篇 |
基础医学 | 165240篇 |
口腔科学 | 33902篇 |
临床医学 | 98609篇 |
内科学 | 233838篇 |
皮肤病学 | 25356篇 |
神经病学 | 92360篇 |
特种医学 | 43585篇 |
外国民族医学 | 178篇 |
外科学 | 181074篇 |
综合类 | 18995篇 |
现状与发展 | 1篇 |
一般理论 | 299篇 |
预防医学 | 82090篇 |
眼科学 | 25957篇 |
药学 | 88573篇 |
3篇 | |
中国医学 | 2824篇 |
肿瘤学 | 70941篇 |
出版年
2021年 | 8920篇 |
2019年 | 10101篇 |
2018年 | 16546篇 |
2017年 | 11913篇 |
2016年 | 12633篇 |
2015年 | 14479篇 |
2014年 | 18043篇 |
2013年 | 26992篇 |
2012年 | 40450篇 |
2011年 | 41446篇 |
2010年 | 22958篇 |
2009年 | 20604篇 |
2008年 | 38523篇 |
2007年 | 40691篇 |
2006年 | 40216篇 |
2005年 | 38959篇 |
2004年 | 37174篇 |
2003年 | 35085篇 |
2002年 | 33989篇 |
2001年 | 60015篇 |
2000年 | 61911篇 |
1999年 | 51639篇 |
1998年 | 11167篇 |
1997年 | 9752篇 |
1996年 | 9836篇 |
1995年 | 9530篇 |
1994年 | 8809篇 |
1993年 | 8079篇 |
1992年 | 38289篇 |
1991年 | 36455篇 |
1990年 | 35160篇 |
1989年 | 34083篇 |
1988年 | 31080篇 |
1987年 | 30230篇 |
1986年 | 28140篇 |
1985年 | 26852篇 |
1984年 | 19095篇 |
1983年 | 16187篇 |
1982年 | 8389篇 |
1979年 | 16869篇 |
1978年 | 11363篇 |
1977年 | 9747篇 |
1976年 | 8450篇 |
1975年 | 9340篇 |
1974年 | 11350篇 |
1973年 | 10764篇 |
1972年 | 10216篇 |
1971年 | 9716篇 |
1970年 | 9207篇 |
1969年 | 8747篇 |
排序方式: 共有10000条查询结果,搜索用时 656 毫秒
1.
2.
3.
4.
Andreas Lundin Martin Annborn Ola Borgquist Joachim Düring Johan Undén Christian Rylander 《Acta anaesthesiologica Scandinavica》2023,67(5):655-662
Patients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno-arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre-planned prospective observational sub-study of the target temperature management 2 trial. The sub-study patients were included at five Swedish sites. Repeated measurements of ∆pCO2 and lactate were conducted at 4, 8, 12, 16, 24, 48, and 72 h after randomization. We assessed the association between each marker and 96-h mortality and their prognostic value for 96-h mortality. One hundred sixty-three patients were included in the analysis. Mortality at 96 h was 17%. During the initial 24 h, there was no difference in ∆pCO2 levels between 96-h survivors and non-survivors. ∆pCO2 measured at 4 h was associated with an increased risk of death within 96 h (adjusted odds ratio: 1.15; 95% confidence interval [CI]: 1.02–1.29; p = .018). Lactate levels were associated with poor outcome over multiple measurements. The area under the receiving operating curve to predict death within 96 h was 0.59 (95% CI: 0.48–0.74) and 0.82 (95% CI: 0.72–0.92) for ∆pCO2 and lactate, respectively. Our results do not support the use of ∆pCO2 to identify patients with early mortality in the postresuscitation phase. In contrast, non-survivors demonstrated higher lactate levels in the initial phase and lactate identified patients with early mortality with moderate accuracy. 相似文献
5.
6.
Gordon K. B. Saburov V. O. Koryakin S. N. Gulidov I. A. Fatkhudinov T. Kh. Arutyunyan I. V. Kaprin A. D. Solov’ev A. N. 《Bulletin of experimental biology and medicine》2022,173(2):281-285
Bulletin of Experimental Biology and Medicine - Fast neutron therapy, which previously has demonstrated effective results, but along with a large number of complications, can again be considered a... 相似文献
7.
Zyuz’kov G. N. Zhdanov V. V. Miroshnichenko L. A. Polyakova T. Yu. Stavrova L. A. Simanina E. V. Minakova M. Yu. Agafonov V. I. Churin A. A. 《Bulletin of experimental biology and medicine》2022,173(5):615-619
Bulletin of Experimental Biology and Medicine - The psychopharmacological effects of a stimulator of functions of progenitor cells of the nervous tissue STAT3 inhibitor (STAT3 Inhibitor XIV, LLL12)... 相似文献
8.
9.
Yevdulov O. V. Yevdulov D. V. Isabekova T. I. Aminov G. I. Aminova I. Yu. 《Biomedical engineering》2022,56(2):146-150
Biomedical Engineering - A mathematical model of a thermoelectric device for the treatment of whitlow by local hypothermia is discussed. The model is based on a solution of the heat conduction task... 相似文献
10.
Md Maksudul Alam Janmaris Marin Fermin Patrick T. Spiller Chaning Burnett Xiaohua Rong Tara Moore-Medlin Caden O. Maxwell Alok R. Khandelwal Cherie-Ann O. Nathan 《Molecular carcinogenesis》2022,61(1):33-44
TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation of the PI3K/AKT/mTOR signaling pathway, we investigated the effect of rapalogs RAD001 and CCI-779 on HPV-negative mutTP53 HNSCC cell lines and xenografts. Rapalogs significantly reduced cell viability and colony formation. Interestingly, rapalogs-induced autophagy with no effect on apoptosis. Pretreatment with autophagy inhibitors, 3-methyladenine (3-MA) and ULK-101 rescued the cell viability by inhibiting rapalog-induced autophagy, suggesting that both RAD001 and CCI-779 induce non-apoptotic autophagy-dependent cell death (ADCD). Moreover, rapalogs upregulated the levels of ULK1 and pULK1 S555 with concomitant downregulation of the mTORC1 pathway. However, pretreatment of cells with rapalogs prevented the ULK-101-mediated inhibition of ULK1 to sustained autophagy, suggesting that rapalogs induce ADCD through the activation of ULK1. To further translate our in vitro studies, we investigated the effect of RAD001 in HPV-negative mutTP53 (HN31 and FaDu) tumor cell xenograft model in nude mice. Mice treated with RAD001 exhibited a significant tumor volume reduction without induction of apoptosis, and with a concomitant increase in autophagy. Further, treatment with RAD001 was associated with a considerable increase in pULK1 S555 and ULK1 levels through the inhibition of mTORC1. 3-MA reversed the effect of RAD001 on FaDu tumor growth suggesting that RAD001 promotes ACDC in HPV-negative mutTP53 xenograft. This is the first report demonstrating that rapalogs promote non-apoptotic ADCD in HPV-negative mutTP53 HNSCC via the ULK1 pathway. Further studies are required to establish the promising role of rapalogs in preventing the regrowth of HPV-negative mutTP53 HNSCC. 相似文献