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Aycan Z Cetinkaya E Darendeliler F Vidinlisan S Bas F Bideci A Demirel F Darcan S Buyukgebiz A Yildiz M Berberoglu M Bundak R 《Clinical endocrinology》2008,68(5):769-772
Background Patients with Turner syndrome (TS) are treated with GH to increase adult height. Although it is well established that GH promotes longitudinal bone growth, the effects of GH treatment on bone density are less clear. Objective To determine how GH treatment affects trabecular bone mineral density (BMD) in girls with TS at prepubertal ages in a prospective multicentre study. Patients and method Twenty‐two patients with TS in the prepubertal period with a mean age of 9·8 ± 2·5 (range 3·6–12·8) years were included in the study. All girls with TS underwent measurement of areal BMD using dual‐energy X‐ray absorptiometry (DXA) to obtain pretreatment anteroposterior (AP) lumbar spine values at L1–L4. Patients received GH (Genotropin) subcutaneously for 1 year at a dose of 0·05 mg/kg/day. Height and weight were measured at 3‐monthly intervals. The AP lumbar spine areal BMD was remeasured using the same technique after 1 year of treatment. Lumbar spine BMD Z‐scores and volumetric BMD (vBMD) Z‐scores were calculated using national standards. Results The height SDS of our cases showed a significant increase with GH therapy. The pretreatment lumbar spine (L1–L4) BMD Z‐score was –1·2 ± 1·2 SD and the vBMD Z‐score was –0·8 ± 1·6 SD. There were no significant changes in these values after 1 year of GH treatment. Prepubertal TS girls more than 11 years of age had lower vBMD Z‐scores (–1·7 ± 1·7 SD) than the girls aged less than 11 (–0·1 ± 1·0 SD) (P < 0·05) at the onset of therapy. No significant changes were observed in these values after 1 year of GH therapy. Conclusions Osteopaenia becomes apparent in prepubertal TS patients as they reach pubertal age. BMD evaluation may be necessary in these prepubertal TS girls at diagnosis. Short‐term GH therapy in these TS patients does not have a significant effect on bone density when measured at a site with a predominance of trabecular bone. 相似文献
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Aycan Fahri Erkan Asli Tanindi Sinan Altan Kocaman Murat Ugurlu Hasan Fehmi Tore 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2016,43(1):29-37
Epicardial adipose tissue thickness is associated with the severity and extent of atherosclerotic coronary artery disease. We prospectively investigated whether epicardial adipose tissue thickness is related to coronary artery disease extent and complexity as denoted by Gensini and Syntax scores, and whether the thickness predicts critical disease.After performing coronary angiography in 183 patients who had angina or acute myocardial infarction, we divided them into 3 groups: normal coronary arteries, noncritical disease (≥1 coronary lesion with <70% stenosis), and critical disease (≥1 coronary lesion with <70% stenosis). We used transthoracic echocardiography to measure epicardial adipose tissue thickness, then calculated Gensini and Syntax scores by reviewing the angiograms.Mean thicknesses were 4.3 ± 0.9, 5.2 ± 1.5, and 7.5 ± 1.9 mm in patients with normal coronary arteries, noncritical disease, and critical disease, respectively (P <0.001). At progressive thicknesses (<5, 5–7, and >7 mm), mean Gensini scores were 4.1 ± 5.5, 19.8 ± 15.6, and 64.9 ± 32.4, and mean Syntax scores were 4.7 ± 5.9, 16.6 ± 8.5, and 31.7 ± 8.7, respectively (both P <0.001). Thickness had strong and positive correlations with both scores (Gensini, r =0.82, P <0.001; and Syntax, r =0.825, P <0.001). The cutoff thickness value to predict critical disease was 5.75 mm (area under the curve, 0.875; 95% confidence interval, 0.825–0.926; P <0.001).Epicardial adipose tissue thickness is independently related to coronary artery disease extent and complexity as denoted by Gensini and Syntax scores, and it predicts critical coronary artery disease. 相似文献
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Deniz Evcik Saime Ay Aral Ege Aycan Turel Vural Kavuncu 《Clinical orthopaedics and related research》2009,467(8):2077-2082
The Knee Outcome Survey-Activities of Daily Living Scale (KOS-ADLS), originally developed in English, is a valid and reliable
self-reported instrument used for patients with various painful knee conditions. We adapted the KOS-ADLS to Turkish and tested
its reliability and validity. We enrolled 142 patients with knee pain in the study. The patients were randomized into two
groups: Group 1 (n = 75) completed the questionnaire twice a week for assessing test-retest reliability and Group 2 (n = 67)
answered the questionnaire and performed additional tests for assessing validity. The intraclass correlation coefficient ranged
from 0.98 to 0.99 with high internal consistency (Cronbach’s alpha, 0.89). Validity-related tests included pain measurement
with a visual analog scale and functional tests, including time measurements for the get-up-and-go and ascending/descending
stairs tests. The visual analog scale score correlated with total score (r = 0.56), function total score (r = 0.53), and symptom
total score (r = 0.45). The ascending/descending stairs test correlated with total score (r = 0.47), function total score
(r = 0.49), and symptom total score (r = 0.31). The get-up-and-go test weakly correlated with all three scores. The Turkish
version of the KOS-ADLS is reliable and valid in evaluating the functional limitations of patients with knee pain.
Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest,
patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.
Each author certifies that his or her institution has approved the human protocol for this investigation, that all investigations
were conducted in conformity with ethical principles of research, and that informed consent for participation in the study
was obtained.
This study was performed at Ufuk University and Kocatepe University. 相似文献
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Sahin Serdar Gundogdu Aycan Nalbantoglu Ufuk Kadioglu Pinar Karaca Zuleyha Hacioglu Aysa Urhan Muhammed Emre Unluhizarci Kursad Demir Ahmet Numan Hora Mehmet Durcan Emre Elbüken Gülsah Dokmetas Hatice Sebile Zuhur Sayid Shafi Kelestimur Fahrettin 《Pituitary》2022,25(3):520-530
Pituitary - Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Oral and fecal... 相似文献
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Subclinical left ventricular systolic and diastolic dysfunction in type 1 diabetic children and adolescents with good metabolic control 下载免费PDF全文