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排序方式: 共有55条查询结果,搜索用时 5 毫秒
1.
Kar Fatih Hacioglu Ceyhan Kar Ezgi Donmez Dilek Burukoglu Kanbak Güngör 《Metabolic brain disease》2022,37(5):1387-1399
Metabolic Brain Disease - The gut microbiota influences brain development and functioning through the gut-brain axis. This is first study regulate maternal gut microbiota and fetal neurodevelopment... 相似文献
2.
Sari I Altuntas F Hacioglu S Kocyigit I Sevinc A Sacar S Deniz K Alp E Eser B Yildiz O Kaynar L Unal A Cetin M 《American journal of hematology》2008,83(4):334-339
The aim of the study is to review the clinical manifestations and the hematological findings of brucellosis and pancytopenia, with or without hematological malignancies. The records of 202 patients with brucellosis were evaluated retrospectively. Among these cases of brucellosis seen in a 6 year period between April 1999 and June 2005, 30 patients with pancytopenia were identified. The most common manifestation was fever, followed by weight loss, anorexia, malaise, arthralgia, and hepatosplenomegaly. Bone marrow biopsies revealed hypercellularity or normocellularity. The most common findings in the bone marrow evaluation were histiocytic hemophagocytosis and granulomas. Among all cases, we diagnosed 5 hematological malignancies (1 acute myelogenous leukemia, 2 acute lymphoblastic leukemia, and 2 multiple myeloma) concurrently with brucellosis. The clinical symptoms and findings were similar in patients with and without malignancies. In cases with malignancies, the bone marrow biopsy revealed predominant primary disease involvement. Significant increases in ESR and CRP, severe anemia and thrombocytopenia were observed in patients with malignancies. Peripheral blood counts in patients without malignancies returned to normal after antibiotic treatment for brucellosis. However, pancytopenia in two patients with malignancies did not recover because of primary resistant disease. We conclude that while histiocytic hemophagocytosis may be considered as a major cause of pancytopenia, leukemic infiltration can also be an extreme and unusual cause of pancytopenia in patients in whom brucellosis was concurrently diagnosed with hematological malignancies. 相似文献
3.
Sahin Serdar Gundogdu Aycan Nalbantoglu Ufuk Kadioglu Pinar Karaca Zuleyha Hacioglu Aysa Urhan Muhammed Emre Unluhizarci Kursad Demir Ahmet Numan Hora Mehmet Durcan Emre Elbüken Gülsah Dokmetas Hatice Sebile Zuhur Sayid Shafi Kelestimur Fahrettin 《Pituitary》2022,25(3):520-530
Pituitary - Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Oral and fecal... 相似文献
4.
Clinical characteristics and therapeutic outcomes of elderly patients with chronic myeloid leukemia: A retrospective multicenter study 下载免费PDF全文
Serdal Korkmaz Mehmet Sinan Dal Ilhami Berber Deniz Goren Sahin Mehmet Hilmi Dogu Orhan Ayyildiz Ilknur Nizam Murat Albayrak Ramazan Esen Sinem Namdaroglu Mehmet Sencan Olga Meltem Akay Sibel Hacioglu Rahsan Yildirim Ali Eser Anil Tombak Cigdem Pala Osman Ilhan 《Geriatrics & Gerontology International》2015,15(6):729-735
5.
Multicenter retrospective analysis regarding the clinical manifestations and treatment results in patients with hairy cell leukemia: twenty‐four year Turkish experience in cladribine therapy 下载免费PDF全文
Sibel Hacioglu Yusuf Bilen Ali Eser Serdar Sivgin Emel Gurkan Rahsan Yildirim Ismet Aydogdu Mehmet Hilmi Dogu Mehmet Yilmaz Omur Kayikci Anil Tombak Irfan Kuku Harika Celebi Meltem Olga Akay Ramazan Esen Serdal Korkmaz Ali Keskin 《Hematological oncology》2015,33(4):192-198
In this multicenter retrospective analysis, we aimed to present clinical, laboratory and treatment results of 94 patients with Hairy cell leukemia diagnosed in 13 centers between 1990 and 2014. Sixty‐six of the patients were males and 28 were females, with a median age of 55. Splenomegaly was present in 93.5% of cases at diagnosis. The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis. Most of the patients with an indication for treatment were treated with cladribine as first‐line treatment. Total and complete response of cladribine was 97.3% and 80.7%. The relapse rate after cladribine was 16.6%, and treatment related mortality was 2.5%. Most preferred therapy (95%) was again cladribine at second‐line, and third line with CR rate of 68.4% and 66.6%, respectively. The 28‐month median OS was 91.7% in all patients and 25‐month median OS 96% for patients who were given cladribine as first‐line therapy. In conclusion, the first multicenter retrospective Turkish study where patients with HCL were followed up for a long period has revealed demographic characteristics of patients with HCL, and confirmed that cladribine treatment might be safe and effective in a relatively large series of the Turkish study population. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
6.
Hacioglu G Yalcin O Bor-Kucukatay M Ozkaya G Baskurt OK 《Clinical hemorheology and microcirculation》2002,26(1):27-32
Red blood cell (RBC) properties were proposed to play role in the development of hypertension (HT). This study aimed at investigating the alterations of RBC deformability and aggregation, in various models of HT in rats. The following four models of HT were developed in rats: one kidney-one clip HT (1K-1C HT), two kidney-one clip HT (2K-1C HT), deoxycorticosterone acetate (DOCA) induced HT (15 mg/kg, 2 times/week, sc) and N-nitro L-arginine methyl ester (L-NAME) induced HT (50 mg/kg/day, 10 weeks, ip). The blood samples were obtained from abdominal aorta, under ether anesthesia, after a period of 10 weeks of increased blood pressure. RBC deformability was determined by ektacytometry. RBC aggregation was measured in autologous plasma and 0.5% dextran 500, using a photometric rheoscope. Plasma fibrinogen concentration was determined by Clauss method. The mean blood pressure in all four HT models were about 140 mmHg, on the day of sampling, compared to approximately 110 mmHg in the control group. RBC deformability was found to be significantly decreased in the L-NAME model of HT. RBC aggregation in autologous plasma was significantly higher than control in 2K-1C, L-NAME and DOCA models, DOCA HT model being the most effective in altering the RBC aggregation. Plasma fibrinogen values were found to be higher than control in 2K-1C and L-NAME HT models, but not in DOCA HT. These results confirm that RBC rheological properties might be altered in HT. It can also be suggested that these alternations may not simply be the result of the vascular effects of HT, but may play role in the development of HT, as the alterations in different HT models were not the same, although the length and magnitude of increased blood pressure were similar. 相似文献
7.
PURPOSE: To investigate the effects of polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) on visual evoked potentials (VEPs) in a one kidney-one clip (1K-1C) hypertension model in rats. METHODS: Five experimental groups were formed: a control group, a sham group, a group supplemented with DHA, a 1K-1C group, and a 1K-1C + DHA group. The DHA groups were treated for 60 days. In the 1K-1C groups, the right kidney was removed and a silver clip with a 0.2-mm gap was placed on the left renal artery. RESULTS: The DHA-supplemented rats had lower blood pressure than their respective controls (p < 0.01). The increased brain and retina thiobarbituric acid reactive substances (TBARS) levels in hypertensive rats were abolished by DHA administration. The brain nitrite levels were lower in the DHA, 1K-1C and 1K-1C + DHA groups compared with the control group (p < 0.01), and the retina nitrite level was higher in the 1K-1C + DHA group compared with the DHA and 1K-1C groups (p < 0.01). There was an improvement of P(2), N(2) and P(3) components following DHA supplementation in 1K-1C hypertensive rats compared with the 1K-1C group. CONCLUSION: The present study suggests that DHA supplementation has the potential to prevent VEP changes caused by an experimental model of hypertension. This state might be related to the lipid peroxidation lowering effect of DHA. 相似文献
8.
Bilgehan Karadag Bulent Vatan Yalcin Hacioglu Dursun Duman Murat Baskurt Ibrahim Keles Zeki Ongen Vural Ali Vural 《Heart and vessels》2009,24(4):247-253
Polymorphonuclear leukocytes play a central role in all stages of the atherothrombotic inflammatory process. The atherothrombotic
activity of polymorphonuclear leukocytes is exerted by mediators such as myeloperoxidase (MPO). Although the role of MPO has
been studied with respect to the development of adverse cardiac events in acute coronary syndromes (ACS), the association
of this molecule with effectiveness of reperfusion in patients receiving thrombolysis is not yet known. The study population
consisted of a total of 158 patients with acute coronary syndromes. Final diagnosis was ST-segment elevation myocardial infarction
in 86 patients, 80 of whom received thrombolysis. Blood samples were drawn at presentation of the patients and serum myeloperoxidase
levels were measured. Reperfusion was defined in terms of electrocardiographic ST-segment resolution. The serum levels of
MPO were found to be correlated with rates of in-hospital adverse events including death (P < 0.001), reinfarction (P < 0.001), recurrent ischemia (P < 0.001), arrhythmias (P < 0.001), clinical heart failure (P < 0.001), and cardiogenic shock (P < 0.001). There was a significant difference in serum MPO levels between subjects with three-vessel disease and two- or one-vessel
disease (P < 0.001). Pre-lytic serum high-sensitivity C-reactive protein levels in patients with successful reperfusion were lower than
in patients with failed reperfusion (P < 0.001). Analysis of patients with ST segment elevation myocardial infarction receiving thrombolytic therapy revealed that
pre-lytic serum MPO levels in patients with successful reperfusion were significantly lower than those of patients with failed
reperfusion (P < 0.001). In the present study, serum MPO levels were found to be a strong predictor of response to thrombolytic treatment
in patients with ST-segment elevation myocardial infarction. Therefore the level of inflammatory activity in acute coronary
syndromes seems to influence the effectiveness of fibrinolysis. 相似文献
9.
Giacomo Mugnai Carlo de Asmundis Burak Hünük Erwin Ströker Darragh Moran Ebru Hacioglu Diego Ruggiero Jan Poelaert Christian Verborgh Vincent Umbrain Stefan Beckers Hugo Enrique Coutino-Moreno Ken Takarada Valentina de Regibus Pedro Brugada Gian-Battista Chierchia 《Journal of interventional cardiac electrophysiology》2016,46(3):307-314
10.
Gupta M Hacioglu Y Kadakia J Ahmadi N Gao Y Mao SS Budoff MJ 《The international journal of cardiovascular imaging》2011,27(7):1015-1023
In this study, we define the correlation between LV volumes (both LV end-diastolic volume [LVEDV] and LV end-systolic volume
[LVESV]) and ejection fraction (EF) on 64 slice multi-detector computed tomography (MDCT). We also determine the accuracy
of all the LV volume (LVV) parameters to detect LV systolic dysfunction (LVSD) and investigate the feasibility of using LVV
as a surrogate of LVSD on prospectively gated imaging to prevent the radiation exposure of retrospective imaging. 568 patients
undergoing 64-detector MDCT were divided into 2 groups: Group 1—subjects without any heart disease and LVEF ≥ 50%; and Group
2—patients with coronary artery disease and LVEF < 50% (defined as LVSD). The LVV (LV cavity only) and Total LV volume (cavity + LV
mass) at end-systole and end-diastole (LVESV, Total LVESV, LVEDV and Total LVEDV) were measured. The upper limit values (mean + 2
SD) of all LVV parameters in Group 1 were used as the reference criterion to diagnose LVSD in Group 2. An exponential correlation
was found between LVEF and all the LVV parameters. The specificity to detect LVSD in Group 2 was >90% and the sensitivity
was 88.9, 83.3, 61.3 and 74.9% by using LVESV, Total LVESV, LVEDV and Total LVEDV, respectively. Systolic and diastolic LV
volumes had a high correlation with LVEF and a high accuracy to detect LVSD. Thus, on prospectively triggered imaging, ventricular
volumes can predict patients with reduced LVEF, and appropriate referrals can be made. 相似文献