红细胞单采术治疗高原红细胞增多症疗效分析

目的探讨红细胞单采术治疗高原红细胞增多症患者的疗效。方法应用血液成分分离机对12例高原红细胞增多症患者行治疗性红细胞单采术,患者在行红细胞单采术的同时采用药物治疗高原红细胞增多引起的并发症。结果 12例患者经红细胞单采术后配合药物治疗,红细胞计数、血红蛋白和血细胞比容均较治疗前明显下降(P0.05),接近正常水平,缓解临床症状,患者的面色及肢端绛紫色好转。结论红细胞单采术对高原红细胞增多症是一种有效的辅助治疗手段,且安全、可靠、不良反应小,具有较好的临床应用价值。     

不同时间段按摩配合穴位注射预防混合痔术后尿潴留的临床观察

目的:比较不同时间段内按摩配合穴位注射治疗混合痔术后尿潴留的疗效差异。方法:将120例混合痔术后患者随机分成对照组、术后4 h治疗组及术后8 h治疗组,每组40例,三组均采取术后常规护理,两个治疗组在术后常规护理的基础上加上手法按摩及足三里穴位局部注射新斯的明。结果:术后4 h治疗组有效率(92.5%)明显高于术后8 h治疗组(77.5%)及对照组(55%)(P0.05);术后4 h治疗组首次排尿时间(33.6±5.8 min)及平均排尿时间(57.4±2.2 min)明显低于术后8 h治疗组(39.5±4.3 min)、(68.9±1.7 min)及对照组(63.3±7.9 min)、(87.4±5.6 min)(P0.05);术后4h治疗组首次排尿量(363.6±158.7 m L)及2 h内排尿总量(447.4±198.2 m L)明显高于术后8 h治疗组(309.5±146.9 m L)、(418.2±191.9 m L)及对照组(175.2±118.1 m L)、(233.8±195.3 m L)(P0.05)。结论:按摩配合穴位注射对于预防混合痔术后尿潴留具有良好的疗效,并且提早干预能有效预防尿潴留的发生。     

Effect of a novel phosphodiesterase type 5 inhibitor,CPD1,on unilateral renal interstitial fibrosis caused by ureteric obstruction in mice北大核心CSCD

Aim To investigate the effects of CPD1,a novel phosphodiesterase 5 inhibitor,on renal pathological phenotype and fibrotic protein expression in renal fibrosis model mice. Methods Male C57BL/6 J mice were divided into three groups randomly(sham group,UUO group and UUO+CPD1 group). Unilateral ureteric obstruction model was constructed by surgery,and CPD1(5 mg·kg-1·d-1)was administered by intragastric administration two hours after the modeling for seven days. HE and Sirius Red staining were used to observe the distribution of tissue structural lesions and fibrosis. Immunohistochemical staining and Western blot were used to detect the expression of fibronectin(FN),α-SMA,collagen-I and kidney injury molecule-1(Kim-1). Results Compared with sham operation group,the renal tubules of mice were dilated and accompanied by a large amount of inflammatory infiltration. Moreover,the expressions of FN,α-SMA,collagen-I and Kim-1 proteins increased significantly(P<0.05)in UUO group. CPD1 treatment improved the kidney structure and decreased the expression of collagen fibers. Furthermore,CPD1 inhibited the expression of FN,α-SMA,collagen-I and Kim-1 markedly(P<0.05). Conclusions Phosphodiesterase 5 inhibitor CPD1 alleviates the progression of renal fibrosis induced by unilateral ureteral obstruction through down-regulating ECM deposition in the extracellular matrix and expression of Kim-1. The specific mechanism remains to be further studied. © 2023 Publication Centre of Anhui Medical University. All rights reserved.