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排序方式: 共有53条查询结果,搜索用时 15 毫秒
1.
Jennifer Klump Ulrike Phillipp Marie Follo Anna Eremin Hannes Lehmann Sigrun Nestel Nikolas von Bubnoff Irina Nazarenko 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(3):875-882
Clinical evidence in oncology argues for the advantages of performing molecular analysis of blood biomarkers to provide information about systemic changes and tumor heterogeneity.Whereas the diagnostic value of cell-free circulating DNA (fcDNA) has successfully been demonstrated in several studies, DNA enclosed in extracellular vesicles (EV) has only recently been described, and its potential diagnostic value is unclear. We established a protocol for separation of EV and fc fractions and tested for presence of mutant BRAFV600E mediating resistance to Vemurafenib and cKITD816V mediating resistance to Imatinib in blood of patients with melanoma and mastocytosis. Our results show that EV contain significantly higher amounts of total DNA as compared to the fc fraction. However, about ten-fold higher copy numbers of the wild type and mutant BRAF and cKIT were detected in the fcDNA fraction supporting its diagnostic value and pointing to differences in fc and EV DNA content. 相似文献
2.
Titus Josef Brinker Fabian Buslaff Caelán Haney Benedikt Gaim Ailís Ceara Haney Selina Marisa Schmidt Marc Phillipp Silchmüller Lava Taha Lena Jakob Hannah Maria Baumert Marvin Hallmann Marlene Heckl Jonas Alfitian Christian Martin Brieske Evgenia Petrova Divizieva Jilada Wilhelm Gabriel Hillebrand Dominik Penka Sanjeevan Raveendranathan Netzwerk Aufklärung gegen Tabak Janina Leonie Suhre 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(11):1453-1461
Smoking is the leading preventable cause of premature death in Germany. The network “Education Against Tobacco” (EAT) is an initiative that was founded in Germany in 2012, in which more than 3500 medical students and physicians engage in volunteer work in about 80 medical faculties in 14 countries. In this article, the concept, activities, objectives and associated research studies oft he EAT initiative are introduced.On the school level, the initiative addresses 10- to 15-year-old secondary school students. In addition to a multimodal approach, school visits use modern media such as facemorphing apps, which are not only used by students (45,000 per year in 14 countries), but by a total of over 500,000 other people as well. The effectiveness of the school-based intervention is currently being investigated in randomised long-term studies with 20,000 adolescents in Germany. A first long-term study demonstrated evidence of a protective effect regarding the onset of smoking, especially among female students, students having a low level of education and students with a migratory background.The programme educates several hundred prospective physicians at 13 (of 28 participating) German medical faculties each year in science-based elective courses for the well-established smoking cessation counselling of patients and sensitises them to the tobacco epidemic. The approved members engage in dialogue with local members of the German house of representatives as “Ärzteverband Tabakprävention”.EAT motivates the prospective generation of physicians, initially through prevention in school settings, to face the challenge of national tobacco control at the university and federal level. 相似文献
3.
Arezu Z. Aliabadi-Zuckermann Johannes Gökler Alexandra Kaider Julia Riebandt Roxana Moayedifar Emilio Osorio Thomas Haberl Phillipp Angleitner Günther Laufer John Forsythe Ivan Knezevic Bosko Skoric Michiel Erasmus Johan van Cleemput Kadir Caliskan Nicolaas De Jonge Zoltan Szabolcs Zsolt Prodán Andreas O. Zuckermann 《The Journal of heart and lung transplantation》2018,37(8):976-984
4.
Steiert Christine Behringer Simon Phillipp Kraus Luisa Mona Bissolo Marco Demerath Theo Beck Juergen Grauvogel Juergen Reinacher Peter Christoph 《Neurosurgical review》2022,45(4):2745-2755
Neurosurgical Review - Defects of the cranial vault often require cosmetic reconstruction with patient-specific implants, particularly in cases of craniofacial involvement. However, fabrication... 相似文献
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Wiechens Bernhard Brockmeyer Phillipp Erfurth‑Jach Teresa Hahn Wolfram 《Clinical oral investigations》2022,26(10):6119-6119
Clinical Oral Investigations - 相似文献
9.
Bernd Kubista Florian Klinglmueller Martin Bilban Martin Pfeiffer Richard Lass Alexander Giurea Phillipp T. Funovics Cyril Toma Martin Dominkus Rainer Kotz Theresia Thalhammer Klemens Trieb Teresa Zettl Christian F. Singer 《International orthopaedics》2011,35(3):401-411
Osteosarcoma is the most common primary malignant bone tumour. Currently osteosarcoma classification is based on histological appearance. It was the aim of this study to use a more systematic approach to osteosarcoma classification based on gene expression analysis and to identify subtype specific differentially expressed genes. We analysed the global gene expression profiles of ten osteosarcoma samples using Affymetrix U133A arrays (five osteoblastic and five non-osteoblastic osteosarcoma patients). Differential gene expression analysis yielded 75 genes up-regulated and 97 genes down-regulated in osteoblastic versus non-osteoblastic osteosarcoma samples, respectively. These included genes involved in cell growth, chemotherapy resistance, angiogenesis, steroid- and neuropeptide hormone receptor activity, acute-phase response and serotonin receptor activity and members of the Wnt/ß-catenin pathway and many others. Furthermore, we validated the highly differential expression of six genes including angiopoietin 1, IGFBP3, ferredoxin 1, BMP, decorin, and fibulin 1 in osteoblastic osteosarcoma relative to non-osteoblastic osteosarcoma. Our results show the utility of gene expression analysis to study osteosarcoma subtypes, and we identified several genes that may play a role as potential therapeutic targets in the future. 相似文献
10.
S M Fikrig G Schiffman J C Phillipp D I Moel 《The Journal of infectious diseases》1978,137(6):818-821
Twenty-three normal subjects and 19 patients with nephrotic syndrome were vaccinated with tridecavalent pneumococcal capsular polysaccharide vaccine of Streptococcus pneumoniae. The antibody response of the nephrotic patients to pneumococcal capsular antigens was equal to that of the control subjects. These findings indicate that patients with nephrotic syndrome, despite hypogammaglobulinemia, can mount an adequate antibody response to pneumococcal polysaccharides and that there is no evidence of suppressor thymus-derived (T) cells of dysfunctioning bone marrow-derived (B) cells in these patients. 相似文献