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U. Brucklacher Prof. Dr. N.H. Brockmeyer C. Riedel 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》2013,64(10):736-742
Off-label use of medicinal products, i.e. beyond their submitted, tested and approved indications, lies between 30 and 90%—depending on the indication. In dermatology, off-label use is of special importance, for even guideline-endorsed standard therapeutic approaches for common dermatological diseases like atopic eczema, psoriasis, or malignant melanoma are to some extent not licensed for these indications. In addition, many of the approximately 5000 dermatological diseases have a low prevalence. For many such orphan diseases, there are no approved drugs, and it is not feasible that licensing studies will be performed for these indications within a foreseeable time. A reliable legal framework for the reimbursement of medicinal products that are used off-label is essential both for patients and to allow physicians to choose the most adequate therapy. Therefore, off-label use expert groups have been convened by the Federal Ministry of Health (BMG) in order to improve patient care. So far this new and innovative approach has not provided any reasonable improvement for many patients with dermatological diseases whose treatment can only be off-label since a comprehensive evaluation of all off-label indications is not possible. The following statement of the former Federal Minister of Health, U. Schmidt, is particularly true for dermatological therapy: “Good oncologic care also requires a good drug treatment—especially in the outpatient setting. The use of drugs which are not or not yet approved for this indication is often required here”. Federal Minister of Health, Ulla Schmidt, 25th German Cancer Congress, 10 March 2002, Berlin. 相似文献
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Wolfgang Fuchs Norbert H. Brockmeyer 《Journal der Deutschen Dermatologischen Gesellschaft》2014,12(6):451-464
In no other medical field former rare infections of the 1980th and 1990th occur again as this is seen in the field of venerology which is as well based on the mobility of the population. Increasing rates of infections in Europe, and increasing bacteriological resistances face health professionals with new challenges. The WHO estimates more than 340 million cases of illnesses worldwide every year. Diseases caused by sexually transmitted infections (STI) in a strict sense are syphilis, gonorrhea, lymphogranuloma venereum, granuloma inguinale, and chancroid. In a wider sense, all illnesses are included which can mainly be transmitted through sexual contact. The term “sexual contact” has to be seen widely, from close physical contact to all variants of sexual behavior. This CME article is an overview of the most common occurring sexually transmitted infections in clinical practice. Both, basic knowledge as well as recent developments are discussed below. 相似文献
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Preliminary Evidence for a Nexus between Rumination,Behavioural Avoidance,Motive Satisfaction and Depression 下载免费PDF全文
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Nico Reinsch Marina Arendt Marie Henrike Geisel Christina Schulze Volker Holzendorf Anna Warnke Till Neumann Norbert H. Brockmeyer Dirk Schadendorf Lewin Eisele Raimund Erbel Susanne Moebus Karl-Heinz Jöckel Stefan Esser On behalf of HIV HEART Study Group the Heinz Nixdorf Recall Investigative Group 《Infection》2017,45(5):659-667
Objectives
Prolonged QT interval is associated with arrhythmias and sudden death. An increased prevalence of QT interval prolongation in human immunodeficiency virus-infected (HIV) subjects was previously described. The impact of different medications and HIV infection itself on the QT interval is rarely investigated in large HIV+ cohorts.Methods
We compared QT interval measurement in 496 HIV(+) patients of the HIV-HEART study (HIVH) and 992 sex- and age-matched controls of the population-based German Heinz Nixdorf Recall study (HNR). QT corrected for heart rate (QTc) >440 ms in male and >460 ms in female was considered pathological. We analysed the impact of HIV status and HIV medication on QTc prolongation in the HIVH subjects.Results
We observed longer QTc in HIVH subjects compared with HNR controls: 424.1 ms ± 23.3 vs. 411.3 ± 15.3 ms for male and 435.5 ms ± 19.6 vs. 416.4 ms ± 17.3 for female subjects (p < 0.0001 for both sexes). Adjusting for QT prolonging medication the mean differences in QTc between the two studies remained significant with 12.6 ms (95% CI 10.5–14.8; p value <0.0001) for male and 19.3 ms (95% CI 14.5–24.2; p value <0.0001) for female subjects. Prolongation of QTc was pathologic in 22.8 vs. 3.9% of HIV(+) and non-infected males and in 12.1 vs. 1.8% of the females [OR of 7.9 (5.0–12.6) and OR of 6.7 (1.8–24.2), respectively]. Smoking behaviour was an independent factor to lengthen QTc in HIV(+) patients. Diabetes mellitus was not a risk factor itself, but might be associated with medication which was associated with LQT. We could not observe any influence of the HIV status, ART, or any co-medication on the QTc.Conclusions
Our study showed that HIV(+) patients had significantly longer QTc intervals compared to the general population. The number of patients with pathologic QTc prolongation was significantly increased in HIV(+) population.10.
Real-World Usage of Educational Media Does Not Promote Parent–Child Cognitive Stimulation Activities
Jason H. Choi Alan L. Mendelsohn Adriana Weisleder Carolyn Brockmeyer Cates Caitlin Canfield Anne Seery Benard P. Dreyer Suzy Tomopoulos 《Academic pediatrics》2018,18(2):172-178