全文获取类型
收费全文 | 5815篇 |
免费 | 286篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 191篇 |
妇产科学 | 133篇 |
基础医学 | 1285篇 |
口腔科学 | 101篇 |
临床医学 | 515篇 |
内科学 | 1045篇 |
皮肤病学 | 113篇 |
神经病学 | 551篇 |
特种医学 | 328篇 |
外科学 | 665篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 334篇 |
眼科学 | 70篇 |
药学 | 424篇 |
中国医学 | 4篇 |
肿瘤学 | 331篇 |
出版年
2021年 | 82篇 |
2020年 | 63篇 |
2019年 | 72篇 |
2018年 | 90篇 |
2017年 | 78篇 |
2016年 | 82篇 |
2015年 | 121篇 |
2014年 | 133篇 |
2013年 | 162篇 |
2012年 | 264篇 |
2011年 | 258篇 |
2010年 | 158篇 |
2009年 | 177篇 |
2008年 | 272篇 |
2007年 | 294篇 |
2006年 | 312篇 |
2005年 | 288篇 |
2004年 | 283篇 |
2003年 | 277篇 |
2002年 | 284篇 |
2001年 | 163篇 |
2000年 | 150篇 |
1999年 | 149篇 |
1998年 | 60篇 |
1997年 | 53篇 |
1996年 | 36篇 |
1995年 | 52篇 |
1994年 | 45篇 |
1993年 | 32篇 |
1992年 | 71篇 |
1991年 | 56篇 |
1990年 | 64篇 |
1989年 | 71篇 |
1988年 | 49篇 |
1987年 | 63篇 |
1986年 | 53篇 |
1985年 | 56篇 |
1984年 | 35篇 |
1979年 | 35篇 |
1935年 | 32篇 |
1934年 | 36篇 |
1933年 | 34篇 |
1930年 | 29篇 |
1928年 | 33篇 |
1927年 | 31篇 |
1926年 | 32篇 |
1925年 | 35篇 |
1924年 | 36篇 |
1923年 | 39篇 |
1922年 | 49篇 |
排序方式: 共有6148条查询结果,搜索用时 15 毫秒
1.
Jos B. Poell Leon J. Wils Arjen Brink Ralf Dietrich Christine Krieg Eunike Velleuer Ilkay Evren Elisabeth R. Brouns Jan G. de Visscher Elisabeth Bloemena Bauke Ylstra Ruud H. Brakenhoff 《International journal of cancer. Journal international du cancer》2023,152(2):227-238
Oral squamous cell carcinomas (OSCCs) develop in genetically altered epithelium in the mucosal lining, also coined as fields, which are mostly not visible but occasionally present as white oral leukoplakia (OL) lesions. We developed a noninvasive genetic assay using next-generation sequencing (NGS) on brushed cells to detect the presence of genetically altered fields, including those that are not macroscopically visible. The assay demonstrated high accuracy in OL patients when brush samples were compared with biopsies as gold standard. In a cohort of Fanconi anemia patients, detection of mutations in prospectively collected oral brushes predicted oral cancer also when visible abnormalities were absent. We further provide insight in the molecular landscape of OL with frequent changes of TP53, FAT1 and NOTCH1. NGS analysis of noninvasively collected samples offers a highly accurate method to detect genetically altered fields in the oral cavity, and predicts development of OSCC in high-risk individuals. Noninvasive genetic screening can be employed to screen high-risk populations for cancer and precancer, map the extension of OL lesions beyond what is visible, map the oral cavity for precancerous changes even when visible abnormalities are absent, test accuracy of promising imaging modalities, monitor interventions and determine genetic progression as well as the natural history of the disease in the human patient. 相似文献
2.
Schneider Ralph Dettmer Marius Peters Nora Lamdark Tenzin Luedi Markus M. Adamina Michel Doll Dietrich 《European Surgery》2022,54(2):117-125
European Surgery - Treatment of pilonidal sinus disease (PSD) requires a tailored approach. A national guideline was published in 2014. The current status of surgical PSD therapy... 相似文献
3.
Michels Guido Horn Rudolf Helfen Andreas Hagendorff Andreas Jung Christian Hoffmann Beatrice Jaspers Natalie Kinkel Horst Greim Clemens-Alexander Knebel Fabian Bauersachs Johann Busch Hans-Jörg Kiefl Daniel Spiel Alexander O. Marx Gernot Dietrich Christoph F. 《Der Anaesthesist》2022,71(4):307-310
Die Anaesthesiologie - 相似文献
4.
Monica Poiani Myriam Labopin Giorgia Battipaglia Dietrich W. Beelen Johanna Tischer Jürgen Finke Arne Brecht Edouard Forcade Arnold Ganser Jakob R. Passweg Helene Labussiere‐Wallet Ibrahim Yakoub‐Agha Kerstin Schfer‐Eckart Nicolaus Kroeger Blandine Guffroy Annalisa Ruggeri Jordi Esteve Arnon Nagler Mohamad Mohty 《American journal of hematology》2021,96(1):40-50
Karyotypic analysis at time of diagnosis has an important value in determining initial response to treatment, remission duration and overall survival (OS) in acute myeloid leukemia (AML). Less is known about its value before allogeneic hematopoietic cell transplantation (allo‐HCT) in patients transplanted with active disease, either relapsed or primary refractory (Rel‐Ref) AML. We explored the impact of cytogenetic risk (stratification according to MRC‐UK) in 2089 patients with either Ref (n = 972) or Rel AML (n = 1117) transplanted during the period 2000‐2017. Overall, 154 patients had a favorable risk, 1283 had an intermediate risk and 652 had an adverse cytogenetic risk. Median follow‐up was 49 months. Compared to the favorable risk group, intermediate and adverse risk patients were associated with worse leukemia‐free survival and OS and also with a higher incidence of relapse. In a subgroup analysis of patients in the intermediate risk group harboring Fms‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD), this remained an important prognostic factor, being associated with worse outcomes. When analyzing patients according to the intensity of the conditioning regimen, no differences were observed for the main transplant outcomes. In conclusion, in patients diagnosed with AML and transplanted with active disease, karyotype remains an important prognostic factor, allowing splitting patients into different risk groups according to their cytogenetics. Similarly, FLT3‐ITD mutation also remains a negative prognostic factor in this population. 相似文献
5.
6.
7.
8.
9.
10.