不同剂量右美托咪定麻醉对老年全髋关节置换术患者认知功能及血hs-CRP的影响

目的探究不同剂量右美托咪定麻醉对老年全髋关节置换术患者认知功能及超敏C反应蛋白(hs-CRP)的影响。方法选取2015年8月至2018年7月在辽宁省鞍山市双山医院接受老年全髋关节置换术治疗的90例患者作为研究对象,随机分为低剂量组和高剂量组,每组45例。低剂量组给予低剂量右美托咪定(0.3μg/kg)麻醉维持,高剂量组给予高剂量右美托咪定(0.9μg/kg)麻醉维持,比较两组术前、术后3 d的简明智力状态检查量表(MMSE)评分及hs-CRP水平。结果术后3 d,低剂量组的MMSE评分(21.62±2.64)分高于高剂量组(18.37±2.52)分,hs-CRP水平(11.68±2.28)mg/L低于高剂量组(15.87±2.36)mg/L,差异均有统计学意义(P<0.05)。结论不同剂量右美托咪定麻醉用于老年全髋关节置换术患者中均可达到良好的麻醉效果,但予以低剂量右美托咪定(0.3μg/kg)麻醉可更好地改善老年全髋关节置换术患者术后的认知功能,预防认知功能障碍,并降低hs-CRP水平。     

股神经阻滞和舒芬太尼用于髋部骨折患者蛛网膜下隙阻滞前摆放体位时的镇痛效果观察

目的:探讨股神经阻滞和舒芬太尼用于髋部骨折患者蛛网膜下隙阻滞前摆放体位时的镇痛效果.方法:将2016年1月-2017年1月髋部骨折患者100例随机数字表法分组.舒芬太尼麻醉组实施舒芬太尼麻醉,股神经阻滞组实施股神经阻滞.比较2组效果;不良麻醉事件;不同时间患者血浆应激指标以及生命体征指标水平.改良的OAA/S镇静评分以及视觉模拟评分.结果:2组的镇痛作用均是100%,P>0.05.在不同时间情况下2组血浆应激指标以及生命体征指标水平并无明显差异,P>0.05.2组均未出现严重的不良反应,P>0.05,其中,舒芬太尼麻醉组有2例出现呼吸抑制,而股神经阻滞组有1例眩晕以及1例恶心呕吐.股神经阻滞组改良的OAA/S镇静评分低于舒芬太尼麻醉组,P<0.05,视觉模拟评分低于舒芬太尼麻醉组,P<0.05.其中,股神经阻滞组改良的OAA/S镇静评分是(1.01±0.11)分,而舒芬太尼麻醉组改良的OAA/S镇静评分是(1.56±0.56)分.股神经阻滞组视觉模拟评分是(3.01±0.12)分,而舒芬太尼麻醉组视觉模拟评分是(3.87±0.67)分.结论:股神经阻滞在髋部骨折麻醉中的效果确切,其和舒芬太尼麻醉对于手术效果相似,但其中股神经阻滞在髋部骨折麻醉中的效果更好,可更好抑制疼痛应激.     

VISX STAR S3准分子激光治疗散光的向量分析

目的运用散光的向量分析法对VISXSTARS3准分子激光治疗中高度散光的疗效进行评价。方法采用回顾性方法研究接受VISXSTARS3准分子激光角膜原位磨镶术（LASIK）的散光患者25例36眼,术前散光度2.0～4.25D,术后随访6个月以上,根据手术前后主觉验光结果 ,运用Alpins散光向量分析法分析目标诱导散光向量（TIA）、手术诱导散光向量（SIA）、错位角（AE）、矫正指数、成功指数（IOS）、变平指数（FI）等向量参数改变。结果平均TIA为（2.68±0.73）D,平均SIA为（2.67±0.8）D;平均矫正指数为0.98±0.18,95%可信区间为（0.93～1.04）,无显著性系统性欠矫或过矫;平均绝对AE为3.30°±3.8°;平均AE为-0.92°±4.98°,95%可信区间为（-2.55°～0.71°）,无显著性系统性轴向错位;平均IOS为0.18±0.17,成功率（ROS）为0.80±0.17,平均FI为0.97±0.18。矫正指数与散光度及球镜度均无显著相关性（r=-0.16,r=0.23,P〉0.05）,成功指数与散光度及球镜度亦无显著相关性（P〉0.05）,TIA与SIA呈正相关（r=0.80,P〈0.05）。结论 VISXSTARS3激光矫治中高度散光的准确性和成功率均较高,向量分析提供了必要的和易于理解的散光改变信息。     

非凝固巩膜扣带术治疗孔源性视网膜脱离

在孔源性视网膜脱离 (网脱 )手术治疗中 ,封闭裂孔是手术成功的关键。为使裂孔能紧贴在手术嵴上并形成牢固粘连 ,在巩膜扣带术中采用巩膜外电凝或冷凝 ,至今仍被认为是手术成功的常规步骤。近年来人们在治疗网脱手术中对巩膜凝固应用的必要性和危害性有了新的认识。我院自 1996年来采用非凝固巩膜扣带术治疗孔源性网脱31例 31眼 ,取得较好效果。1　资料与方法1 1　一般资料　本组患者均为孔源性网脱。共 31例 31眼 ,男性 2 2眼 ,女性 9眼。年龄最大 6 4岁 ,最小 17岁。发病时间 2周内 10眼 ,～ 3个月 17眼 ,～ 14个月 4眼。视力光感指数 15…     

端粒酶抑制剂对葡萄膜黑色素瘤细胞生长的抑制作用

Objective To study the restrain effects of two telomerase inhibitors included IFN-α2b (interferon-α2b)and CDDP(cisplatin;cis-dichlorodiamine platinum)to uveal melanoma cells of human eyes,and to provide theory bases for chemotherary of uveal melanoma.Methods Applied IFN-α2b and CDDP to the primary cultured uveal melanoma cells of human eyes individually with different concentration and duration,and compared with control group.Morphological changes were observed by inverted optical and electronic microscope,and the restrain effects were detected by MTT.Results More and more morphological changes of restraint and apoptosis of cells were observed with the increasing concentration and duration of IFN-α 2b and CDDP.When action durations were 72 h.the cells were inhibited with the concentration more than 500 IU/ml(IFN-α 2b)and 1.00 mg/L(CDDP)respectively.The cells restrain rates were(66.1±4.7)%and(74.0+3.3)%with the concentration more than 5000 IU/ml(IFN-α2b)and 10 mg/L (CDDP),and the rates were higher than before(P<0.001).When concentrations were 5000 IU/ml(IFN-α2b)and 10.00 mg/L(CDDP),cells were inhibited at 48 h and the restrain rates were(67.9±8.1)%and(76.5±1.61%at 72 h,respectively,(P相似文献   

端粒酶抑制剂对葡萄膜黑色素瘤细胞生长的抑制作用

Objective To study the restrain effects of two telomerase inhibitors included IFN-α2b (interferon-α2b)and CDDP(cisplatin;cis-dichlorodiamine platinum)to uveal melanoma cells of human eyes,and to provide theory bases for chemotherary of uveal melanoma.Methods Applied IFN-α2b and CDDP to the primary cultured uveal melanoma cells of human eyes individually with different concentration and duration,and compared with control group.Morphological changes were observed by inverted optical and electronic microscope,and the restrain effects were detected by MTT.Results More and more morphological changes of restraint and apoptosis of cells were observed with the increasing concentration and duration of IFN-α 2b and CDDP.When action durations were 72 h.the cells were inhibited with the concentration more than 500 IU/ml(IFN-α 2b)and 1.00 mg/L(CDDP)respectively.The cells restrain rates were(66.1±4.7)%and(74.0+3.3)%with the concentration more than 5000 IU/ml(IFN-α2b)and 10 mg/L (CDDP),and the rates were higher than before(P<0.001).When concentrations were 5000 IU/ml(IFN-α2b)and 10.00 mg/L(CDDP),cells were inhibited at 48 h and the restrain rates were(67.9±8.1)%and(76.5±1.61%at 72 h,respectively,(P相似文献   

端粒酶抑制剂对葡萄膜黑色素瘤细胞生长的抑制作用

Objective To study the restrain effects of two telomerase inhibitors included IFN-α2b (interferon-α2b)and CDDP(cisplatin;cis-dichlorodiamine platinum)to uveal melanoma cells of human eyes,and to provide theory bases for chemotherary of uveal melanoma.Methods Applied IFN-α2b and CDDP to the primary cultured uveal melanoma cells of human eyes individually with different concentration and duration,and compared with control group.Morphological changes were observed by inverted optical and electronic microscope,and the restrain effects were detected by MTT.Results More and more morphological changes of restraint and apoptosis of cells were observed with the increasing concentration and duration of IFN-α 2b and CDDP.When action durations were 72 h.the cells were inhibited with the concentration more than 500 IU/ml(IFN-α 2b)and 1.00 mg/L(CDDP)respectively.The cells restrain rates were(66.1±4.7)%and(74.0+3.3)%with the concentration more than 5000 IU/ml(IFN-α2b)and 10 mg/L (CDDP),and the rates were higher than before(P<0.001).When concentrations were 5000 IU/ml(IFN-α2b)and 10.00 mg/L(CDDP),cells were inhibited at 48 h and the restrain rates were(67.9±8.1)%and(76.5±1.61%at 72 h,respectively,(P相似文献   

角膜缘干细胞移植联合丝裂霉素C治疗复发性翼状胬肉

目的 观察自体角膜缘干细胞移植联合丝裂霉素C治疗复发件翼状胬肉的疗效.方法 将58例(62眼)复发性翼状胬肉患者随机分为2组,治疗组(32例,35跟)采用角膜缘于细胞移植联合应用丝裂霉素C;对照组(26例,27眼)单纯采用角膜缘干细胞移植术治疗.术后随访6～30个月并比较疗效.结果 治疗组1眼冉复发,再复发率2.86%;对照组5眼再复发,再复发率18.52%,两组差异具有统计学意义(P<0.05).治疗组角膜创面上皮平均愈合时间为(8.34 ±2.38)d,对照组为(7.21±2.55)d,差异无统计学意义(P>0.05).两组均未发现严重并发症.结论 角膜缘干细胞移植联合应用丝裂霉素C治疗复发性翼状胬肉再复发率低,并发症少,为复发性翼状胬肉安全和有效的治疗方法 .     

VISX Star S3准分子激光原位角膜磨镶术治疗中高度散光

目的 观察VISXStarS3准分子激光原位角膜磨镶术治疗中高度散光的有效性、可预测性及安全性.方法 采用回顾性的研究方法对25例36只眼首次接受VISXStarS3准分子激光原位角膜磨镶术的患者进行分析,入选患者散光均在2.0D以上且无角膜瓣并发症,术后随访至少6个月以上,观察术后裸眼视力、最佳眼镜矫正视力、残余散光度、散光的向量改变以及术后眩光发生情况.结果 术前柱镜度平均(-2.65±0.70)D(-2.0～-4.25D),平均球镜度(-6.28±3.05)D,范围+0.5～-13.25D;术后83.3%视力在1.0以上,97.2%视力在0.5以上;16.7%最好矫正视力下降1行,没有出现最佳矫正视力下降超过1行的情况.术后平均残余散光度(0.46±0.44)D(0～1.25D),58.3%残余散光在±0.5D以内,94.4%残余散光在±1.0D以内,平均矫正指数为(0.98±0.18),平均失误角(3.30±3.8)度.25例中,6例患者术后至少有1只眼出现持续的夜间视力障碍或眩光.结论 VISXStarS3准分子激光原位角膜磨镶术治疗中高度散光有良好的有效性、可预测性及安全性,但仍有相当比例的患者发生夜间眩光.     

非凝固巩膜扣带术治疗孔源性视网膜脱离

在孔源性视网膜脱离手术治疗中,封闭裂孔是手术成功的关键.为使裂孔能紧贴在手术嵴上并形成牢固粘连,在巩膜扣带术中采用巩膜外电凝或冷凝,至今仍被认为是手术成功的常规步骤.近年来临床实践使人们在治疗视网膜脱离中对巩膜凝固应用的必要性和危害性有了新的认识.我院自1997年来采用非凝固巩膜扣带术治疗孔源性视网膜脱离31例31眼,取得较好效果,现将结果报告如下.