角膜缘干细胞移植联合丝裂霉素C治疗复发性翼状胬肉

目的 观察自体角膜缘干细胞移植联合丝裂霉素C治疗复发件翼状胬肉的疗效.方法 将58例(62眼)复发性翼状胬肉患者随机分为2组,治疗组(32例,35跟)采用角膜缘于细胞移植联合应用丝裂霉素C;对照组(26例,27眼)单纯采用角膜缘干细胞移植术治疗.术后随访6～30个月并比较疗效.结果 治疗组1眼冉复发,再复发率2.86%;对照组5眼再复发,再复发率18.52%,两组差异具有统计学意义(P<0.05).治疗组角膜创面上皮平均愈合时间为(8.34 ±2.38)d,对照组为(7.21±2.55)d,差异无统计学意义(P>0.05).两组均未发现严重并发症.结论 角膜缘干细胞移植联合应用丝裂霉素C治疗复发性翼状胬肉再复发率低,并发症少,为复发性翼状胬肉安全和有效的治疗方法 .

Limbal stem cell transplantation combined with mitomycin C in the treatment of recurrent pterygium

Objective To investigate the efficacy of autologous limbal stem eel] transplantation eombined with mitomyein C in the treatment of recurrent pterygium. Methods Fifty-eight cases (62 eyes) with recurrent pterygium were randomly divided into two groups: limbal stem cell transplantation combined with mitomycin C group(treatment group, 32 cases, 35 eyes)and limbal stem cell transplantation group (control group, 26 cases, 27 eyes). The efficacy was compared after operation with follow-up for 6 to 30 months. Results One eye recurrence was noted in the treatment group, the recurrent rate was 2.86%. Five eyes recurrence were noted in the control group, the recurrence rate was 18.52%. There was significant difference between two groups (P < 0.05). The average epithelial recovering time of eoneal wound was (8.34 ±2.38) d in treatment group and (7.21±2.55) d in control group, the difference was not significant (P> 0.05). No severe postoperative complications were found in two groups. Conclusions Limbal stem cells transplantation combined with mitomycin C can decrease the recurrent rate and complications. It is a safe and effective therapeutic method of recurrent pterygium.