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E1TorVibioCholeraeStrainSM_6andJiangsu1dStrain¥JiangXiaowan,etal.ACTAACADEMIAEMEDICINAENANJING,1994,14(2):163-164AbstractE1To?.. 相似文献
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Synaptotagmin(Syt)constitutes a family of membrane-trafficking proteins,so far nearly 20 Syts have beendiscovered.Extensive work showed that synatotagmins were a potential Ca~(2+) sensor for regulated exocytosis.Thisstudy was to investigate the expression and location of synaptotagmin Ⅱ(Syt2)in RBL-2H3(RBL)and its role inregulating exocytosis of RBL.The expression of Syt2 in RBL was confirmed by Western blot.The recombinantexpression vector pEGFP-N1-Syt2 was constructed and transfected into RBL by electroporation,the stabletransfectant RBL-Syt2-S expressing fusion protein Syt2-EGFP were obtained and Syt2 was highly concentrated atplasma membrane with little detected in cytoplasm.To analyze the role of Syt2 during exocytosis of RBL,therelease of cathepsin D was assayed by immunoblotting.Compared with control,the release of cathepsin D byRBL-Syt2-S was markedly decreased.The results indicated that Syt2 played a negative regulation in exocytosis oflysosomes in RBL.Cellular & Molecular Immunology.2005;2(3):205-209. 相似文献
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为了实现科技期刊编辑、出版发行工作的电子化,推进科技信息交流的网络化进程,我刊现已入网“万方数据资源系统(ChinaInfo)数字化期刊群”。所以,向本刊投稿并录用的稿件文章,将一律由编辑部统一纳入万方数据资源系统(ChinaInfo),进入因特网提供信息服务。凡有不同意者,请另投它刊。本刊对编入的文稿,均不再另付稿酬。 万方数据资源系统数字化期刊群是国家“九五”重点科技攻关项目,截至1999年底,已有1000种期刊全文上网(网址:http:∥www.chinainfo.gov.cn/periodical)。本刊全文内容按照统一格式制作编入万方数据资源系统后,读者可通过因特网进入万方数据资源系统(ChinaInfo)免费(一年后开始酌情收费)查询浏览本刊内容,也欢迎各界朋友向我刊提出宝贵意见、建议,或订阅本刊。 《河南医学研究》编辑部 二○○一年二月第10卷 相似文献
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Wang Hua Ma Xiansong :Tongji Hospital Affiliated to Tongji Medical College Huazhong U-niversity of Science Technology Wuhan Chen Yinyao : Medical School of Fudan University Shanghai Wang Liji : Department of International Cooperation Ministry of Health Beijing 《中国医院》2001,(5)
As one of the basic human rights, health is an important guarantee for productivity. The authors introduce the Andersen's behavioral model of health service use,as well as the conception and classification of access to health services based on the model. Meanwhile,the relative guidelines and the impact on the health reform of China are discussed, compared with America's and China's. This paper propounds three strategic priority of productivity development. 相似文献
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International Workshop on the Impact of the Environment on Reproductive Health 《Progress in human reproduction research》1991,(20):1-11
The WHO workshop on the impact of the environment on reproductive health is summarized. Topics include the nature of environmental factors affecting reproductive health, environmental factors blamed for declining sperm quantity and quality, the effects of natural and man-made disasters on reproductive health, chemical pollutants, how the environment damages reproductive health, and research needs for better research methodologies and surveillance data. Recommendations are made to: 1) promote international research collaboration with an emphasis on consistency of methodological approaches for assessing developmental and reproductive toxicity, on development of improved surveillance systems and data bases, an strengthening international disaster alert and evaluation systems; 2) promote research capabilities for multidisciplinary studies, for interactive studies of the environment and cellular processes, and for expansion of training and education; and 3) take action on priority problems of exposure to chemical, physical, and biological agents, of exposure to pesticides among specific populations, and of inadequate screening methods for identification of environmental chemicals. The costs of environmental injury to reproduction include subfertility, intrauterine growth retardation, spontaneous abortion, and various birth defects. Developed country's primary threats are from chemical pollution, radiation, and stress. There is a large gap in knowledge. Caution is urged in understanding the direct relationship between environmental causes and infertility. Sexual health is difficult to assess and research is suggested. Exposure to excessive vitamin A and toxic chemicals are cited as agents probably having serious effects on malformations. Sperm quality has declined over the decades; there is speculation about the potential causes. The effects of radiation such as at Chernobyl are described. Toxic chemical exposure such as in Bhopal, India killed thousands. Neurological damage is reported for fetuses and infants exposed to methyl mercury. There is the beginning of evidence that complications of pregnancy may be related to pollution levels surrounding industrial plants. Reproductive health is affected through chromosome damage and cell destruction, prenatal death, altered growth, fetal abnormalities, postnatal death, functional learning deficits, and premature aging. 相似文献
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Study on Metabolites of Aconitum Alkaloids in Human Urine 总被引:1,自引:0,他引:1
ForMaster‘sDegree:SUNYing Supervisor:Prof.ZHANGHong-gui ZHONGda-fang ZHANGHan-qi 《中国药学》2003,12(1):54-55
TheaconitebelongstoplantsofgenusAconituminfamilyofRanunculaceaandhavenotableclinicalfunctionsintreatingrheumaticarthritis ,heartfailure ,etc .However,accidentsofaconitine(fromaconite)poisoningfrequentlyoccurtomanypeopletakingtheseherbs .Theplantsofthisfamilycontainaconitine ,mesaconitine ,hypaconitineandotheraco nitumalkaloids .Theyarehighlytoxic ,andtheirtreatmentdoseapproachestothetoxicdoseorlethaldose .Duringtheperiodfrom 1989- 1995 ,morethan 30casesofpoisoningcausedbyaconitineinsometradit… 相似文献
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