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铜对造血、细胞生长、免疫及内分泌功能均有重要作用。铜过多可能与肿瘤及冠心病的发病有关。但是,铜与慢性支气管炎(下称慢支)的关系研究尚少,值得探讨。近年我们发现老年人体内缺锌,锌对老年人外周血辅助性T细胞与抑制性T细胞平衡状态有调节作用。铜与T细胞亚群的关系尚未见报道。 相似文献
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Action potentials of isolated Purkinje's cellsin dogs and the electrophysiological actions ofdl-demethylcoclaurine(DMC)on dog Purkinje'scells were studied by glass microelectrodes.The effects of DMC on the action potentialof Purkinje's cells were:(1)increase of am-plitude of the plateau phase;(2)enhancementof repolarization of phase 3 and shortening ofAPD;(3)DMC(1×10~(-7)g/ml)caused a shorten-ing of APD without any significant change ofthe ERP,while DMC(1×10~(-6)g/ml)caused shor-tening of both APD and ERP;(4)DMC(10~(-6)g/ml)increased the slope of phase 4,decreasedthe threshold of depolarization,and increasedthe automaticity of the Purkinje's cells;(5)theaction of DMC on the Purkinje's cells was onlypartially blocked by tetraodontoxin and vera-pamil.The above results suggest that:(1)LMCenhances the influx of both Na~+ and Ca~(++) inslow channel;(2)relatively high concentrationsof DMC may induce tachyarrhythmias,whilelower concentrations may prevent the arrhyth-mias;(3)DMC may increase the ventricular ratein patients with complete heart block abovebundle of His but not in blockages below Hisbundle;(4)there is a slight increase of ERF bylow concentration of DMC DMC thus appearssafer than isopreterenol in the treatment ofbradyarrhythmias. 相似文献
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本文介绍用简化胸腺素治疗26例细胞免疫功能低下的病毒性心肌炎患者所取得的疗效,多数病例治疗后临床症状明显改善;植物血凝素皮肤试验由阴性转为阳性,抗心肌抗体由阳性转阴,免疫球蛋白IgG及IgA明显下降,E-RFC形成较治疗前增高,由40.86±5.63上升至49.07±4.03(P<0.001),3H.TdR.ICJ体外PHA淋巴细胞转化试验示单个核细胞的CPM平均值由治疗前46796±20516上升至86501±28450(P<0.001),血浆抑制因子对单个核细胞的抑制率由71.29±21.029下降为27.71±25.98(P<0.001),并能使粘附细胞功能恢复,本文列胸腺素改善病毒性心肌炎细胞免疫的机理进行了讨论。 相似文献
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卵磷脂胆固醇酰基转移酶的酶学测定法 总被引:1,自引:0,他引:1
卵磷脂—胆固醇酰基转移酶(以下简称LCAT)催化下列反应:把卵磷脂C_2位上的脂肪酸转移到非酯化胆固醇上,生成溶血卵磷脂和胆固醇脂。反应在血浆内进行。人体胆固醇代谢运转中,该酶是关键环节之一,故测定LCAT活性对研究冠心病的脂质代谢实属十分必要。LCAT的活性测定方法大体上有三类:①免疫学方法①,“②共同基质法”(the common—substrate method),③自身基质法 相似文献
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作者检测了67例冠心病患者和127例正常人的血小板粘附性(pAd)和血小板集聚性(pAg)。急性心肌梗塞(AMI)患者pAd明显升高(P<0.01),心绞痛患者次之(P<0.05)。除AMI症状发作3天内检测pAg外,在冠心病各亚组中血小板最大聚集率(%max)明显高于正常对照组(P<0.01),以不稳定型心绞痛者为最高。AMI症状发作3天内检测者,%max较低(P<0.05)。3例冠心病患者的血小扳超微结构显示血小板内颗粒较正常音减少。本文结果提示,冠心病患者血小板功能异常以及血小板形态发生改变。 相似文献