全文获取类型
收费全文 | 70962篇 |
免费 | 5961篇 |
国内免费 | 1056篇 |
专业分类
耳鼻咽喉 | 1223篇 |
儿科学 | 1415篇 |
妇产科学 | 1263篇 |
基础医学 | 11116篇 |
口腔科学 | 1122篇 |
临床医学 | 6763篇 |
内科学 | 13505篇 |
皮肤病学 | 2223篇 |
神经病学 | 5763篇 |
特种医学 | 3802篇 |
外国民族医学 | 2篇 |
外科学 | 8867篇 |
综合类 | 1982篇 |
现状与发展 | 4篇 |
一般理论 | 18篇 |
预防医学 | 4401篇 |
眼科学 | 1927篇 |
药学 | 6230篇 |
2篇 | |
中国医学 | 992篇 |
肿瘤学 | 5359篇 |
出版年
2023年 | 386篇 |
2022年 | 371篇 |
2021年 | 2092篇 |
2020年 | 1251篇 |
2019年 | 1771篇 |
2018年 | 2037篇 |
2017年 | 1579篇 |
2016年 | 2188篇 |
2015年 | 2957篇 |
2014年 | 3518篇 |
2013年 | 3982篇 |
2012年 | 5697篇 |
2011年 | 5528篇 |
2010年 | 3405篇 |
2009年 | 2876篇 |
2008年 | 3952篇 |
2007年 | 3878篇 |
2006年 | 3491篇 |
2005年 | 3190篇 |
2004年 | 2736篇 |
2003年 | 2476篇 |
2002年 | 2265篇 |
2001年 | 1471篇 |
2000年 | 1329篇 |
1999年 | 1168篇 |
1998年 | 563篇 |
1997年 | 493篇 |
1996年 | 359篇 |
1995年 | 367篇 |
1994年 | 303篇 |
1993年 | 332篇 |
1992年 | 739篇 |
1991年 | 775篇 |
1990年 | 634篇 |
1989年 | 681篇 |
1988年 | 669篇 |
1987年 | 682篇 |
1986年 | 569篇 |
1985年 | 576篇 |
1984年 | 431篇 |
1983年 | 364篇 |
1982年 | 270篇 |
1981年 | 251篇 |
1980年 | 213篇 |
1979年 | 323篇 |
1978年 | 293篇 |
1977年 | 197篇 |
1974年 | 217篇 |
1973年 | 230篇 |
1972年 | 181篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
2.
3.
4.
Moderate sedatives have been increasingly used to improve patient comfort during flexible bronchoscopy (FB). However, routine use of moderate sedation during FB is controversial because its efficacy and safety are not well established.This study aims to evaluate the efficacy and safety of moderate sedation during FB.A search was made of Medline, EMBASE, and the Cochrane Library to May 2014.Randomized controlled trials (RCTs) and quasi-RCTs were included.The main analysis was designed to examine the efficacy of moderate sedation during FB in sedation than no-sedation.The willingness to repeat FB was significantly more in sedation than no-sedation (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.11–4.73; P = 0.02; I2 = 22.5). The duration of FB was shorter in sedation group than no-sedation group (standardized mean difference [SMD] −0.21; 95% CI −0.38 to −0.03; P = 0.02; I2 = 78.3%). Event of hypoxia was not significantly different between sedation and no-sedation groups (OR 0.86; 95% CI 0.42–1.73; P = 0.67; I2 = 0%). The SpO2 during procedure was not different between sedation and no-sedation groups (SMD −0.14; 95% CI −0.37 to 0.08; P = 0.21; I2 = 49.9%). However, in subgroup analysis without supplemental oxygen, the SpO2 was significantly lower in sedation than no-sedation group (SMD −0.45; 95% CI −0.78 to −0.11; P = 0.01; I2 = 0.0%).According to this meta-analysis, moderate sedation in FB would be useful in patients who will require repeated bronchoscopies as well as safe in respiratory depression. To our knowledge, although the various sedative drugs are already used in the real field, this analysis was the first attempt to quantify objective results. We anticipate more definite and studies designed to elucidate standardized outcomes for moderate sedation in FB. 相似文献
5.
Seulbi Lee Hyesook Park Soontae Kim Eun-Kyung Lee Jiyoung Lee Young Sun Hong Eunhee Ha 《International journal of hygiene and environmental health》2019,222(3):533-540
Background
It has been reported that particulate matter (PM) is associated with cardiovascular diseases (CVD) while metabolic syndrome is also an important risk factor for CVD. However, few studies have investigated the epidemiological association between PM and metabolic syndrome.Objective
To investigate the association between one-year exposure to PM with an aerodynamic diameter <2.5?μm (PM2.5) and the risk of metabolic syndrome in Korean adults without CVD.Methods
Exposure to PM2.5 was assessed using a Community Multiscale Air Quality (CMAQ) model. Metabolic syndrome was defined by National Cholesterol Education Program Adult Treatment Panel III. Andersen and Gill model with time-varying covariates, considering recurrent events, was used to investigate the association between one-year average PM2.5 and the risk of incident metabolic syndrome in 119,998 adults from the national health screening cohort provided by Korea National Health Insurance from 2009 to 2013.Results
Higher risk of metabolic syndrome, waist-based obesity, hypertension, hypertriglyceridemia, low HDL cholesterol, and hyperglycemia were significantly associated with a 10-μg/m3 increase in PM2.5 [adjusted hazard ratio (HR): 1.070, 1.510, 1.499, 1.468, 1.627 and 1.380, respectively]. In addition, the risk of metabolic syndrome associated with PM2.5 exposure was significant in the consistently obese group (obese at baseline and endpoint).Conclusion
Exposure to one-year average PM2.5 is associated with an increased risk of metabolic syndrome and its components in adults without CVD. These associations are particularly prominent in the consistently obese group (obese at baseline and endpoint). Our findings indicate that PM2.5 affects the onset of MS and its components which may lead to increase the risk of CVD. 相似文献6.
Hyun Jong Choi Jong Ho Moon Yun Nah Lee Hyun Su Kim Ji Su Ha Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park 《Digestive endoscopy》2015,27(7):772-775
Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS. 相似文献
7.
8.
目的探讨腹腔镜经腹腹膜前疝修补术(TAPP)放置腹膜前引流对术后血肿及血清肿的影响。
方法选取2016年6月至2018年5月,江苏省苏州市中西医结合医院收治的单侧腹股沟疝患者90例,随机分为试验组和对照组,2组患者均行TAPP手术。试验组放置腹膜前引流管,对照组不放置引流管。收集2组患者的一般资料、手术相关资料及随访资料进行统计学分析,对比2组患者术后血肿及血清肿发生率差异。
结果全部患者均完成手术及随访。2组患者的一般资料、疝位置、疝分型、手术时间、住院花费、术后住院时间差异无统计学意义(P>0.05)。2组患者的术后发热发生率、急性疼痛发生率差异无统计学意义(P>0.05)。试验组术后血肿发生率明显低于对照组(P<0.05),试验组患者术后1和3个月血清肿发生率明显低于对照组,差异有统计学意义(P<0.05)。2组患者1年随访均观察到1例复发的病例,差异无统计学意义(P>0.05);随访期内2组患者均未出现感染的病例。
结论TAPP中,放置腹膜前引流管能够有效降低患者术后血肿和血清肿的发生率,同时并不增加感染和复发风险。 相似文献
9.
Kim Dae Woo Kim Yong Min Min Jin-Young Kim Jeong-Whun Kim Jin-Kook Mo Ji-Hun Shin Jae-Min Cho Kyu-Sup Kwak Sang Gyu Shin Seung-Heon 《European archives of oto-rhino-laryngology》2020,277(3):761-765
European Archives of Oto-Rhino-Laryngology - Fungus ball (FB) is the most common type of fungal rhinosinusitis and the prevalence of FB has increased over the past 10 years. The aim of... 相似文献
10.