首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1080580篇
  免费   73429篇
  国内免费   1658篇
耳鼻咽喉   15624篇
儿科学   29965篇
妇产科学   27171篇
基础医学   154475篇
口腔科学   32309篇
临床医学   91786篇
内科学   209730篇
皮肤病学   23388篇
神经病学   86099篇
特种医学   44664篇
外国民族医学   103篇
外科学   176459篇
综合类   19019篇
现状与发展   1篇
一般理论   270篇
预防医学   68797篇
眼科学   25580篇
药学   83313篇
  3篇
中国医学   2487篇
肿瘤学   64424篇
  2018年   11506篇
  2017年   9101篇
  2016年   10635篇
  2015年   12098篇
  2014年   15366篇
  2013年   22290篇
  2012年   31506篇
  2011年   32014篇
  2010年   18944篇
  2009年   17630篇
  2008年   31454篇
  2007年   33363篇
  2006年   34107篇
  2005年   33433篇
  2004年   32252篇
  2003年   31281篇
  2002年   30633篇
  2001年   59461篇
  2000年   61400篇
  1999年   51237篇
  1998年   12079篇
  1997年   10583篇
  1996年   10443篇
  1995年   9641篇
  1994年   8923篇
  1993年   8211篇
  1992年   37450篇
  1991年   35853篇
  1990年   34709篇
  1989年   33702篇
  1988年   30600篇
  1987年   29851篇
  1986年   27811篇
  1985年   26620篇
  1984年   18972篇
  1983年   16057篇
  1982年   8419篇
  1981年   7332篇
  1979年   17058篇
  1978年   11535篇
  1977年   9837篇
  1976年   8555篇
  1975年   9650篇
  1974年   11518篇
  1973年   10825篇
  1972年   10326篇
  1971年   9800篇
  1970年   9260篇
  1969年   8708篇
  1968年   7959篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Quality of Life Research - The COVID-19 pandemic might add to the stressors experienced by people living with rheumatic diseases. This study aimed to examine rheumatic patients’ functional...  相似文献   
2.
Intratumor heterogeneity is a main cause of the dismal prognosis of glioblastoma (GBM). Yet, there remains a lack of a uniform assessment of the degree of heterogeneity. With a multiscale approach, we addressed the hypothesis that intratumor heterogeneity exists on different levels comprising traditional regional analyses, but also innovative methods including computer-assisted analysis of tumor morphology combined with epigenomic data. With this aim, 157 biopsies of 37 patients with therapy-naive IDH-wildtype GBM were analyzed regarding the intratumor variance of protein expression of glial marker GFAP, microglia marker Iba1 and proliferation marker Mib1. Hematoxylin and eosin stained slides were evaluated for tumor vascularization. For the estimation of pixel intensity and nuclear profiling, automated analysis was used. Additionally, DNA methylation profiling was conducted separately for the single biopsies. Scoring systems were established to integrate several parameters into one score for the four examined modalities of heterogeneity (regional, cellular, pixel-level and epigenomic). As a result, we could show that heterogeneity was detected in all four modalities. Furthermore, for the regional, cellular and epigenomic level, we confirmed the results of earlier studies stating that a higher degree of heterogeneity is associated with poorer overall survival. To integrate all modalities into one score, we designed a predictor of longer survival, which showed a highly significant separation regarding the OS. In conclusion, multiscale intratumor heterogeneity exists in glioblastoma and its degree has an impact on overall survival. In future studies, the implementation of a broadly feasible heterogeneity index should be considered.  相似文献   
3.
4.
ABSTRACT

Objective: Dry eye is reported to be associated with several neurological diseases. The aim of this study is to evaluate the patients with hemiplegia after stroke for dry eye and compare their results with a control group.

Materials and methods: Forty-five patients with hemiplegia and 45 individuals as the control group were included in the study. Tear function tests (Schirmer and tear breakup time) and a dry eye questionnaire for dry eye symptoms (ocular surface disease index) were performed and the results of the two groups were compared.

Results: Schirmer test results were significantly lower in the post-stroke hemiplegia group compared to the control group (11.3 ± 8.2 mm and 20.6 ± 11.6 mm, respectively, p < .001). Tear breakup time results were significantly lower in the post-stroke hemiplegia group compared to the control group (7.9 ± 3.1 s and 12.1 ± 4.3 s, respectively, p < .001). Ocular surface disease index scores were not significantly different between hemiplegia and control groups (21.6 ± 20.0 and 19.8 ± 13.9, respectively, p = .635). Schirmer scores lower than 10 mm (60% and 30%, p < .001) and tear breakup time results lower than 10 s (65.6% and 28.9%, p < .001) were also higher in the hemiplegia group compared to control group.

Conclusion: We found lower Schirmer test and tear breakup time results and similar OSDI scores in hemiplegia patients compared to controls. Hemiplegia patients may have dry eye without typical symptoms. This should be taken into consideration in the follow-up and rehabilitation of post-stroke hemiplegia patients.  相似文献   
5.
6.
Introduction: Percutaneous renal mass biopsy has evolved over the last decade with improvements on previous pitfalls including low tissue yield, high non-diagnostic rates, and complications. As understanding of tumor biology and natural history of renal cortical neoplasms has improved, percutaneous renal mass biopsy is poised to have an expanding role in an area characterized by individualized management and refined risk stratification.

Areas covered: This review summarizes the evolution of renal mass biopsy to its current state with respect to outcomes, indications, and clinical guidelines.

Expert opinion: With improved understanding of differential biological potential of renal cortical neoplasms combined with technical improvements in diagnostic yield and accuracy, utilization of renal mass biopsy is becoming an important adjunct to patient care in a broad range of clinical scenarios, including active surveillance, thermal ablation, and use of primary systemic therapy in localized and advanced settings.  相似文献   

7.
8.
9.
10.
neurogenetics - Human RNF213, which encodes the protein mysterin, is a known susceptibility gene for moyamoya disease (MMD), a cerebrovascular condition with occlusive lesions and compensatory...  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号