全文获取类型
收费全文 | 290946篇 |
免费 | 26062篇 |
国内免费 | 7765篇 |
专业分类
耳鼻咽喉 | 2245篇 |
儿科学 | 4227篇 |
妇产科学 | 4431篇 |
基础医学 | 45629篇 |
口腔科学 | 6222篇 |
临床医学 | 20155篇 |
内科学 | 39059篇 |
皮肤病学 | 6061篇 |
神经病学 | 22283篇 |
特种医学 | 9426篇 |
外国民族医学 | 37篇 |
外科学 | 24547篇 |
综合类 | 36525篇 |
现状与发展 | 41篇 |
一般理论 | 8篇 |
预防医学 | 19030篇 |
眼科学 | 3854篇 |
药学 | 39358篇 |
86篇 | |
中国医学 | 15767篇 |
肿瘤学 | 25782篇 |
出版年
2024年 | 250篇 |
2023年 | 4096篇 |
2022年 | 5673篇 |
2021年 | 11414篇 |
2020年 | 10510篇 |
2019年 | 10741篇 |
2018年 | 10615篇 |
2017年 | 11222篇 |
2016年 | 10962篇 |
2015年 | 11221篇 |
2014年 | 14085篇 |
2013年 | 18287篇 |
2012年 | 15137篇 |
2011年 | 18195篇 |
2010年 | 12831篇 |
2009年 | 13036篇 |
2008年 | 14480篇 |
2007年 | 14833篇 |
2006年 | 13679篇 |
2005年 | 12643篇 |
2004年 | 10791篇 |
2003年 | 9581篇 |
2002年 | 7586篇 |
2001年 | 6797篇 |
2000年 | 5698篇 |
1999年 | 4877篇 |
1998年 | 3718篇 |
1997年 | 3810篇 |
1996年 | 3426篇 |
1995年 | 3383篇 |
1994年 | 3297篇 |
1993年 | 2886篇 |
1992年 | 2479篇 |
1991年 | 2262篇 |
1990年 | 2025篇 |
1989年 | 1620篇 |
1988年 | 1567篇 |
1987年 | 1400篇 |
1986年 | 1388篇 |
1985年 | 2021篇 |
1984年 | 1748篇 |
1983年 | 1330篇 |
1982年 | 1359篇 |
1981年 | 1142篇 |
1980年 | 1066篇 |
1979年 | 855篇 |
1978年 | 537篇 |
1977年 | 448篇 |
1976年 | 446篇 |
1975年 | 300篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
《Journal of pediatric surgery》2023,58(7):1274-1280
BackgroundPerianal abscesses and anal fistulas are common. The principle of intention-to-treat has not been considered in previous systemic reviews. Thus, the comparison between primary and post-recurrence management was confused, and the recommendation of primary treatment is obscure. The current study aims to identify the optimal initial treatment for pediatric patients.MethodsUsing PRISMA guidelines, studies were identified from MEDLINE, EMBASE, PubMed, Cochrane Library, and Google Scholar without any language or study design restriction. The inclusion criteria include original articles or articles with original data, studies of management for a perianal abscess with or without anal fistula, and patient age of <18 years. Patients with local malignancy, Crohn's disease, or other underlying predisposing conditions were excluded. Studies without analyzing recurrence, case series of <5, and irrelevant articles were excluded in the screening stage. Of the 124 screened articles, 14 articles had no full texts or detailed information. Articles written in a language other than English or Mandarin were translated by Google Translation first and confirmed with native speakers. After the eligibility process, studies that compared identified primary managements were then included in the qualitative synthesis.ResultsThirty-one studies involving 2507 pediatric patients met the inclusion criteria. The study design consisted of two prospective case series of 47 patients and retrospective cohort studies. No randomized control trials were identified. Meta-analyses for recurrence after initial management were performed with a random-effects model. Conservative treatment and drainage revealed no difference (Odds ratio [OR], 1.222; 95% Confidential interval [CI]: 0.615–2.427, p = 0.567). Conservative management had a higher risk of recurrence than surgery without statistical significance (OR 0.278, 95% CI: 0.109–0.707, p = 0.007). Compared with incision/drainage, surgery can prevent recurrence remarkably (OR 4.360, 95% CI: 1.761–10.792, p = 0.001). Subgroup analysis of different approaches within conservative treatment and operation was not performed for lacking information.ConclusionStrong recommendations cannot be made due to the lack of prospective or randomized controlled studies. However, the current study based on real primary management supports initial surgical intervention for pediatric patients with perianal abscesses and anal fistula to prevent recurrence.Level of evidenceType of study: Systemic review; Evidence level: Level II. 相似文献
2.
《Research in social & administrative pharmacy》2022,18(9):3694-3698
In this paper, we argue that understanding and addressing the problem of poor-quality medical products requires a more interdisciplinary approach than has been evident to date. While prospective studies based on rigorous standardized methodologies are the gold standard for measuring the prevalence of poor-quality medical products and understanding their distribution nationally and internationally, they should be complemented by social science research to unpack the complex set of social, economic, and governance factors that underlie these patterns. In the following sections, we discuss specific examples of prospective quality surveys and of social science studies, highlighting the value of cross-sector partnerships in driving high-quality, policy-relevant research in this area. 相似文献
3.
4.
5.
6.
《Value in health》2022,25(6):1010-1017
ObjectivesSurvival extrapolation for chimeric antigen receptor T-cell therapies is challenging, owing to their unique mechanistic properties that translate to complex hazard functions. Axicabtagene ciloleucel is indicated for the treatment of relapse or refractory diffuse large B-cell lymphoma after 2 or more lines of therapy based on the ZUMA-1 trial. Four data snapshots are available, with minimum follow-up of 12, 24, 36, and 48 months. This analysis explores how survival extrapolations for axicabtagene ciloleucel using ZUMA-1 data can be validated and compared.MethodsThree different parametric modeling approaches were applied: standard parametric, spline-based, and cure-based models. Models were compared using a range of metrics, across the 4 data snapshot, including visual fit, plausibility of long-term estimates, statistical goodness of fit, inspection of hazard plots, point-estimate accuracy, and conditional survival estimates.ResultsStandard and spline-based parametric extrapolations were generally incapable of fitting the ZUMA-1 data well. Cure-based models provided the best fit based on the earliest data snapshot, with extrapolations remaining consistent as data matured. At 48 months, the maximum survival overestimate was 8.3% (Gompertz mixture-cure model) versus the maximum underestimate of 33.5% (Weibull standard parametric model).ConclusionsWhere a plateau in the survival curve is clinically plausible, cure-based models may be helpful in making accurate predictions based on immature data. The ability to reliably extrapolate from maturing data may reduce delays in patient access to potentially lifesaving treatments. Additional research is required to understand how models compare in broader contexts, including different treatments and therapeutic areas. 相似文献
7.
目的探讨肺癌患者化疗后的癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)和鳞状上皮细胞癌抗原(SCC-Ag)表达变化。方法选取2017年5月至2020年2月间南京市六合区人民医院收治的100例肺癌患者,将这些患者作为肺癌组,另随机选取同期100例健康体检人员作为健康组。统计分析两组人员化疗前的血清NSE、CEA、SCC-Ag表达水平、肺癌组化疗成功患者化疗前后的血清NSE、CEA、SCC-Ag表达水平、肺癌组化疗失败患者化疗前后的血清NSE、CEA、SCC-Ag表达水平。结果肺癌组患者化疗前的血清NSE、CEA和SCC-Ag表达水平均高于健康组,差异均有统计学意义(均P <0.05)。肺癌组化疗成功患者化疗后的血清NSE、CEA和SCC-Ag表达水平均低于化疗前,均高于健康组,差异均有统计学意义(P <0.05)。肺癌组化疗失败患者化疗后的血清NSE、CEA、SCC-Ag表达水平均高于化疗前,均高于健康组,差异均有统计学意义(P <0.05)。结论对肺癌患者的NSE、CEA、SCC-Ag表达水平进行检测能够将化疗效果有效反映出来,进而有效指导临床的下一步治疗工作,从而有效改善患者预后。 相似文献
8.
9.