全文获取类型
收费全文 | 65篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 3篇 |
基础医学 | 5篇 |
临床医学 | 9篇 |
内科学 | 6篇 |
皮肤病学 | 1篇 |
神经病学 | 6篇 |
特种医学 | 1篇 |
外科学 | 4篇 |
综合类 | 18篇 |
预防医学 | 3篇 |
药学 | 5篇 |
中国医学 | 8篇 |
肿瘤学 | 2篇 |
出版年
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2017年 | 1篇 |
2015年 | 2篇 |
2014年 | 4篇 |
2012年 | 2篇 |
2011年 | 3篇 |
2010年 | 3篇 |
2009年 | 1篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 4篇 |
2005年 | 5篇 |
2004年 | 6篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1996年 | 3篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1978年 | 2篇 |
排序方式: 共有72条查询结果,搜索用时 421 毫秒
1.
Oskar Kornasiewicz Marcin D?bski Michal Grat Barbara Lenartowicz Marta St?pnowska Anna Sza?as Ewa Bar-Andziak Marek Krawczyk 《Archives of Medical Science》2014,10(4):801-805
Introduction
Type 1 iodothyronine deiodinase (D1) converts thyroxin (T4) into tri-iodothyronine (T3). Strong evidence indicates that thyroid hormone metabolism is disturbed in neoplasms such as thyroid and breast cancer. However, there is limited data concerning the function of the D1 enzyme in liver tumors. We aimed to estimate the enzymatic activity of D1 in two different common liver tumors.Material and methods
We obtained 20 tumor samples from patients who had undergone a liver resection. Of the tissue samples, there were 13 benign lesions of focal nodular hyperplasia (FNH) and 7 malignant lesions of hepatocellular carcinomas (HCC). The D1 activity was assessed by measuring the amount of radioactive iodine released in reaction to D1-catalysed deiodination. Groups were compared by the Mann-Whitney non-parametrical test for independent trials, and the Kruskal Wallis test.Results
The enzymatic activity of D1 was not significantly altered in the FNH group (median = 536 fmol/mg of protein/min; p = 0.972) and HCC group (367 fmol/mg; p = 0.128) when compared to matched normal liver parenchyma controls (546 fmol/mg and 556 fmol/mg, respectively).Conclusions
Liver parenchyma expresses high levels of D1. The results clearly revealed that D1 activity was not significantly different between benign and malignant tumors (FNH and HCC) compared to healthy liver parenchyma cells. 相似文献2.
Lei Mao Xiao-Han Chen Jian-Hua Zhuang Peng Li Yi-Xin Xu Yu-Chen Zhao Yue-Jin Ma Bin He You Yin 《World Journal of Clinical Cases》2020,8(1):76-87
BACKGROUND Post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of patients.Biochemical indicators such as blood lipids and blood pressure are affected by many factors,and the ability of evaluating the progress of patients with PSCI is insufficient.Therefore,it is necessary to find sensitive markers for predicting the progress of patients and avoiding PSCI.Recent studies have shown thatβ-amyloid protein 1-42(Aβ1-42)and thyroid hormone levels are closely related to PSCI,which may be the influencing factors of PSCI,but there are few related studies.AIM To investigate the relationship between serum levels of Aβand thyroid hormones in acute stage and PSCI and its predicted value.METHODS A total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this study.Baseline data and serological indicators were recorded to assess cognitive function of patients.All patients were followed up for 1 year.Their cognitive functions were evaluated within 1 wk,3 mo,6 mo and 1 yr after stroke.At the end of follow-up,the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score,and the relationship between biochemical indexes and the progression of PSCI was explored.RESULTS Compared with patients with non-PSCI,the levels of Aβ1-42,triiodothyronine(T3)and free thyroxin were lower in the patients with PSCI.Repeated measures analysis of variance showed that the overall content of Aβ1-42 and T3 in PSCI was also lower than that of the non-PSCI patients.Further analysis revealed that Aβ1-42(r=0.348),T3(r=0.273)and free thyroxin(r=0.214)were positively correlated with disease progression(P<0.05),suggesting that these indicators have the potential to predict disease progression and outcome.Cox regression analysis showed that Aβ1-42 and T3 were important factors of PSCI.Then stratified analysis showed that the lower the Aβ1-42 and T3,the higher risk of PSCI in patients who were aged over 70,female and illiterate.CONCLUSION Aβ1-42 and T3 have the ability to predict the progression of PSCI,which is expected to be applied clinically to reduce the incidence of PSCI and improve the quality of life of patients. 相似文献
3.
4.
胰岛素和甲状腺素对家兔脂蛋白脂肪酶和肝脂酶活性的影响 总被引:2,自引:0,他引:2
本研究给家兔注射胰岛素或喂甲状腺素,以观察体内LPL、H-TGL活性的改变。结果表明这两种激素对血浆PHLA(LPL+H-TGL)影响相同;而对不同组织的LPL有不同的作用。同时观察了血浆脂蛋白水平的改变,结果分析表明:注射胰岛素后HDL水平的升高作同PHLA升高正相关(r=0.852,P<0.05);喂甲状腺素后LDL水平升高同PHLA升高正相关(r=0.920,P<0.05)。结果提示。不同组织LPL活性的改变对脂蛋白代谢有不同的影响,脂肪组织LPL活性的升高可能有助于HDL水平的升高。 相似文献
5.
目的观察充血性心力衰竭(CHF)中医辨证分型与甲状腺激素(T3、T4、TSH)、心房利钠多肽(ANP)、心功能参数[左室射血分数(LVEF)、平均周缘纤维缩短速度(mVcf)、A峰/E峰(A/E)]的关系。方法将100例CHF患者分为4个证型组,检测各组心功能参数、ANP、甲状腺激素,并与对照组(23例)相同指标比较。结果CHF兼水肿血瘀证患者血浆ANP明显高于对照组(P<0.05);T3较对照组、心气虚证组、兼阴虚证组与兼血瘀证组明显降低(P<0.0l,P<0.0l,P<0.05,P<0.01);LVEF、mVcf较心气虚证、兼阴虚证、兼血瘀证组均明显降低(P均<0.01);心气虚证组、兼阴虚证组与兼血瘀证组的T4水平较兼水肿血瘀证组均明显升高(P<0.05,P<0.01,P<0.01);心气虚证组、兼阴虚证组、兼血瘀证与水肿血瘀证组的A/E比值较对照组均明显增高(P均<0.01)。T3与LVEF、T4均呈正相关(r=0.200,P<0.05;r=0.293,P<0.01);与ANP呈负相关(r=-0.263,P<0.01)。T4与A/E呈负相关(r=-0.226,P<0.05)。结论T3、T4降低与ANP增高可能是CHF兼水肿血瘀证患者LVEF下降的重要原因之一。T4降低则可能为CHF4型中医分型患者A/E比值逐步增高而导致左室舒张功能不全逐渐加重的重要原因之一。 相似文献
6.
目的:观察中药泻火养阴散治疗初发毒性弥漫性甲状腺肿(格雷夫斯病)的治疗效果。方法:60例患者随机分为两组,治疗组(30例)用中药泻火养阴散合他巴唑治疗,对照组(30例)单用他巴唑治疗,并对两组患者治疗前及治疗后2周、4周、12周的中医症候积分及甲状腺激素水平进行分析比较。结果:治疗组治疗后2周、4周、12周的症候积分及甲状腺激素水平较治疗前下降(P<0.05或P<0.01),并优于同期对照组(P<0.05)。结论:中药泻火养阴散合他巴唑治疗格雷夫斯病,能快速、有效地改善患者的临床症状及降低甲状腺激素水平,减少他巴唑用量。 相似文献
7.
糖尿病酮症酸中毒治疗前后的甲状腺激素变化 总被引:1,自引:0,他引:1
测定65例糖尿病酮症酸中毒患者治疗前及治疗后1周、2周甲状腺激素;同时测定糖尿病控制组(对照组)甲状腺激素。结果:糖尿病酮症酸中毒治疗前血清rT3明显高,T3、FT3明显低,T4、FT4无明显变化。随病情好转,各项指标逐渐恢复,2周后甲状腺激素恢复至糖尿病控制组水平。说明甲状腺激素变化与糖尿病酮症酸中毒病情轻重有关。 相似文献
8.
急性脑外伤后血清甲状腺激素催乳素皮质醇和C肽的动态观察及其临床意义 总被引:1,自引:0,他引:1
为进一步了解脑外伤后体内甲状腺激素、催乳素、皮质醇和C肽的变化及其临床意义,对55例急性脑外伤患者血清甲状腺激素、催乳素、皮质醇和C肽进行了动态观察,并对反映伤情的格拉斯哥昏迷计分(GCS)和反映预后的格拉斯哥预后计分(GOS)分别进行了多元逐步回归分析。结果:①脑外伤组血清3,5,3′三碘甲状腺原氨酸(T3)、甲状腺素(T4)、3,3′,5′L三碘甲状腺原氨酸(rT3)较对照组有明显改变,在动态观察中催乳素(PRL)、皮质醇(COL)未见有显著改变。②不同伤情的各种激素改变不同,rT3和C肽水平与损伤程度呈正相关。③采用多因素分析方法对伤情的估计和对预后的预测进行了初步探讨,并建立了有统计学意义的回归方程。本研究表明,急性脑外伤后血清甲状腺激素和C肽水平的变化与伤情有密切关系,回归方程的建立,对急性脑外伤患者的抢救治疗及其预后判断有一定的临床指导意义 相似文献
9.
N. N. Barykina V. F. Chugui T. A. Alekhina V. G. Kolpakov E. A. Ivanova A. V. Maksyutova A. V. Kulikov 《Bulletin of experimental biology and medicine》2001,132(1):620-621
The role of thyroid hormones in predisposition to cataleptic reaction was investigated. GC rats with genetic predisposition to catalepsy were characterized by decreased serum thyroxin content in comparison with Wistar rats. Thyroidectomy even more reduced the blood concentration of thyroxin in GC rats 30 days postoperation and augmented predisposition to catalepsy in both rat strains. 相似文献
10.
重型病毒性肝炎血清甲状腺激素水平检测及临床意义 总被引:1,自引:0,他引:1
目的 探讨重型病毒性肝炎患者血清甲状腺激素水平与肝损害程度关系及临床意义.方法 应用放射免疫法测定54例重型病毒性肝炎、41例急性病毒性肝炎患者及30例正常人血清甲状腺激素水平.结果 重型病毒性肝炎T3、T4、TSH水平显著低于急性病毒性肝炎及正常人(P<0.05);rT3则增高(P<0.05).T3、T4与血浆Alb呈正相关,L、TSH与PT,rT3与ALT呈负相关.重型病毒性肝炎死亡者T3、T4、TSH显著低于存活者(P<0.01).rT3则增高(P<0.01).结论 重型病毒性肝炎患者甲状腺激素水平可作为反映肝功能的敏感指标,对判断疾病严重程度、预后有重大价值. 相似文献