苏励教授治疗强直性脊柱炎经验介绍

苏励教授认为，脊柱在人体的位置处于皮里膜外，半表半里。强直性脊柱炎病在脊柱，故痰瘀之邪也盘踞在半表半里。治疗宜内清外透结合，在清里基础上外透，使邪有出路，从而清除盘踞在半表半里之邪实。并结合外治法以增加疗效。     

CO2/He-Ne联合激光治疗尿道肉阜109例对比分析

尿道肉阜多见于中年以上的妇女,其中部分患者可以完全无任何症状,有些患者可表现为出血、尿道口灼痛、小便不适或摩擦损伤、感染出血等.对该病传统的常规治疗多采用手术切除,出血多且易复发.本文采用CO2/He-Ne激光联合治疗尿道肉阜,疗效显著.现报道如下.     

霉菌性上颌窦炎的CT表现——附3例报告

霉菌性上颌窦炎较少见,与炎症、肿瘤难以区别。本文报告经手术、病理证实的3例,以提高对本病的认识。1 临床资料 例1,男,50岁,反复左上颌牙疼痛,伴同侧头痛8年,加重1周。查体:左侧鼻腔狭窄,中下鼻甲肥大,左中鼻道腔前端有一花生米大小新生物。横断及冠状位     

Oddi括约肌功能异常与胆管胆色素结石病

1887年,意大利一位名为Ruggero Oddi的大学四年级医学生在其毕业论文中首次提出了十二指肠乳头括约肌的概念,被后人证实并命名为Oddi括约肌以示纪念。120年来随着医学科学的不断发     

Osteoimmunological effects of macrophages北大核心

BACKGROUND: Macrophages have received extensive attention from scholars for their remarkable osteoimmunological effects, and their functions and applications have become a research hot spot. The current research mainly involves the origin, polarization and osteoimmunological effects of macrophages and their applications in bone repair. OBJECTIVE: To confirm the outstanding research value and application prospects of macrophages in bone tissue engineering through reviewing research advances in osteoimmunological effects of macrophages and their applications in bone repair. METHODS: PubMed, Web of Science and CNKI databases were used to search the related articles published from 2010 to 2022. The search terms were “macrophage polarization, bone, osteogenesis, osteoimmunology, biomaterials, tissue engineering”. The searches to English and Chinese language publications were limited. A small number of old classic literature was also included. An initial screening was performed by reading the titles and abstracts to exclude literature that was not relevant to the topic of the article, and 120 papers were finally included for the analysis of the results. RESULTS AND CONCLUSION: (1) Macrophages include monocyte-derived inflammatory macrophages and tissue-resident macrophages, of which different tissue-resident macrophages have different combinations of developmental origins; most tissue-resident macrophages originate from the yolk sac during the embryonic period. (2) Macrophages, highly pastic cells, undergo M1 or M2 macrophage polarization and release pro-or anti-inflammatory factors in response to different stimuli. Alternatively, macrophage polarization is regulated by multiple signaling pathways, including the AMPK-mTOR, Notch, MAPK, STAT, NF-кB, and Akt signaling pathways. (3) The osteoimmunological effects of macrophages involve the crosstalk between macrophages and skeletal cells. The effective application of osteoimmunological effects of macrophages in bone repair can be realized by modifying the physicochemical properties of biomaterials such as stiffness, roughness, pore size, and hydrophilicity or by combining single or multiple biologically active substances such as drugs, cytokines, metal ions, and microRNA. © 2023, Publishing House of Chinese Journal of Tissue Engineering Research. All rights reserved.     

经直肠超声实时引导在精囊镜手术中的应用研究

目的探讨经直肠超声实时引导在射精管梗阻性无精子症或少弱精子症患者精囊镜手术中的应用价值。方法回顾性分析2011年9月至2015年12月北京大学第三医院经直肠超声实时引导行精囊镜手术治疗的25例射精管梗阻性无精子症或少弱精子症患者的临床资料。患者年龄(29.4±4.5)岁;精液量0.4(0~2.8)ml,精液pH值6.5(5~7.5),精子总数0(0~580)百万个,精子密度0(0~90.7)百万个/ml,精子活率0(0~24.1%),结合MRI、经直肠超声检查等初步诊断为梗阻性无精子症或少弱精子症。其中13例为前期常规精囊镜手术失败患者(无法找到通道进入射精管和精囊)。均行经直肠超声实时引导下精囊镜射精管梗阻疏通术,分析手术成功率、并发症及随访结果。手术成功的定义为精囊镜疏通射精管后顺利进入精囊。结果25例中21例(84%)精囊镜成功进入精囊腺,手术时间75(31,148)min,术后所有患者均无严重并发症。4例(16%)手术失败患者中,1例术中探查考虑为先天发育不良,2例双侧均未见明确射精管开口,1例术中诊断为Müllerian管囊肿,未见明确精阜小凹及双侧射精管开口。21例精囊镜手术成功者术后3~6个月复查,精液量2.0(0~5.2)ml,精子总数28(0~832)百万个,精子密度5.6(0~110.3)百万个/ml,精子活率5.4%(0~63.6%),与术前精液量[0.4(0~2.8)ml]、精子总数[0(0~342)百万个]、精子密度[0(0~90.7)百万个/ml]、精子活率[0(0~24.1%)]比较,差异均有统计学意义(P<0.05)。在17例电话随访5~9年的患者中,3例配偶自然妊娠受孕;9例精液质量改善但患者配偶未自然受孕,行体外受精-胚胎移植技术受孕。结论术中经直肠超声引导可以增加精囊镜手术的成功率和安全性,对常规精囊镜手术困难的射精管梗阻性无精子症或少弱精子症效果良好。     

全球针对家族史高危人群的结直肠癌筛查指南推荐意见的系统综述

目的 对全球现有结直肠癌家族史高危人群筛查指南的更新进展及推荐意见进行系统总结和评价。方法 以“结直肠癌”“筛查”“指南”“共识”“推荐”“家族史”以及“colorectal cancer”“screening”“guideline”“recommendation”“family history”为关键词,并补充其自由词,系统检索中国知网、万方数据知识服务平台、PubMed、Embase、Cochrane Library、Web of Science,并且同时检索官网刊登的结直肠癌筛查指南/共识作为补充,语种限定为中文和英文。截至2022年5月24日,共20篇有效文献。对纳入文献的基本信息、针对家族史人群的推荐意见等进行摘录整理及汇总描述。结果 在20篇文献中,大多数国家/地区/机构根据结直肠癌家族史人群的亲属关系等级,对筛查起止年龄、筛查方式及筛查周期提出建议。多数指南针对有1例60岁前患结直肠癌一级亲属的人群,推荐筛查起始年龄为40岁或比患病亲属诊断年龄提前10年,推荐的筛查方式多为结肠镜。结论 目前全球多数结直肠癌家族史高危人群筛查指南主要针对一级亲属家族史、以结肠镜作为主要筛查方式。本文将为我国针对结直肠癌家族史高危人群筛查策略的更新提供参考依据,进而完善结直肠癌筛查与早诊早治实践。     

“非典”病毒源于动物？

在没有完全战胜“非典”之前,怀疑导致这次非典型肺炎的病毒来源于犬、猫等宠物的观点引起许多人担心。中国农业大学动物医学院临床医学系主任林德贵教授就抗击“非典”的特殊时期人们关注的人与家养宠物健康的知识作了介绍。 林德贵教授说,非典型肺炎病毒是否来源于动物没有被证实,只是科研人员的多种推测之一,更多     

羞怯对网络交往的影响:自我意识的中介作用

目的:考察自我意识在大学生羞怯与网络交往关系中的中介作用。方法:采用大学生羞怯量表、自我意识量表和大学生网络交往问卷对781名大学生进行考察。结果:1羞怯与自我意识、网络交往总分显著正相关(r=0.483,0.260;P0.01);自我意识与网络交往总分显著正相关(r=0.261,P0.01);2羞怯通过自我意识的完全中介效应(△χ~2=5.43,△df=1,△χ~2/△df=5.436.63)对大学生网络交往产生影响,羞怯对大学生网络交往没有直接效应。结论:自我意识在大学生羞怯与网络交往关系中起到中介作用。