全文获取类型
收费全文 | 22616篇 |
免费 | 2072篇 |
国内免费 | 719篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 233篇 |
妇产科学 | 159篇 |
基础医学 | 1153篇 |
口腔科学 | 148篇 |
临床医学 | 1614篇 |
内科学 | 3710篇 |
皮肤病学 | 297篇 |
神经病学 | 1866篇 |
特种医学 | 225篇 |
外国民族医学 | 1篇 |
外科学 | 834篇 |
综合类 | 2394篇 |
现状与发展 | 2篇 |
一般理论 | 3篇 |
预防医学 | 1216篇 |
眼科学 | 173篇 |
药学 | 9178篇 |
6篇 | |
中国医学 | 1443篇 |
肿瘤学 | 711篇 |
出版年
2023年 | 405篇 |
2022年 | 457篇 |
2021年 | 857篇 |
2020年 | 867篇 |
2019年 | 941篇 |
2018年 | 939篇 |
2017年 | 976篇 |
2016年 | 888篇 |
2015年 | 878篇 |
2014年 | 1595篇 |
2013年 | 2495篇 |
2012年 | 1439篇 |
2011年 | 1492篇 |
2010年 | 1210篇 |
2009年 | 978篇 |
2008年 | 932篇 |
2007年 | 939篇 |
2006年 | 804篇 |
2005年 | 708篇 |
2004年 | 595篇 |
2003年 | 574篇 |
2002年 | 411篇 |
2001年 | 399篇 |
2000年 | 297篇 |
1999年 | 256篇 |
1998年 | 220篇 |
1997年 | 216篇 |
1996年 | 206篇 |
1995年 | 196篇 |
1994年 | 166篇 |
1993年 | 202篇 |
1992年 | 196篇 |
1991年 | 143篇 |
1990年 | 141篇 |
1989年 | 113篇 |
1988年 | 119篇 |
1987年 | 84篇 |
1986年 | 92篇 |
1985年 | 143篇 |
1984年 | 122篇 |
1983年 | 93篇 |
1982年 | 96篇 |
1981年 | 71篇 |
1980年 | 73篇 |
1979年 | 55篇 |
1978年 | 66篇 |
1977年 | 57篇 |
1976年 | 48篇 |
1975年 | 43篇 |
1974年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Association of Multimodal Pain Control with Patient-Reported Outcomes in Children Undergoing Surgery
《Journal of pediatric surgery》2023,58(6):1206-1212
IntroductionOur aim was to describe practices in multimodal pain management at US children's hospitals and evaluate the association between non-opioid pain management strategies and pediatric patient-reported outcomes (PROs).MethodsData were collected as part of the 18-hospital ENhanced Recovery In CHildren Undergoing Surgery (ENRICH-US) clinical trial. Non-opioid pain management strategies included use of preoperative and postoperative non-opioid analgesics, regional anesthetic blocks, and a biobehavioral intervention. PROs included perioperative nervousness, pain-related functional disability, health-related quality of life (HRQoL). Associations were analyzed using multinomial logistic regression models.ResultsAmong 186 patients, 62 (33%) received preoperative analgesics, 186 (100%) postoperative analgesics, 81 (44%) regional anesthetic block, and 135 (73%) used a biobehavioral intervention. Patients were less likely to report worsened as compared to stable nervousness following regional anesthetic block (relative risk ratio [RRR]:0.31, 95% confidence interval [CI]:0.11–0.85), use of a biobehavioral technique (RRR:0.26, 95% CI:0.10–0.70), and both in combination (RRR:0.08, 95% CI:0.02–0.34). There were no associations of non-opioid pain control modalities with pain-related functional disability or HRQoL.ConclusionUse of postoperative non-opioid analgesics have been largely adopted, while preoperative non-opioid analgesics and regional anesthetic blocks are used less frequently. Regional anesthetic blocks and biobehavioral interventions may mitigate postoperative nervousness in children.Level of evidenceIII. 相似文献
2.
《Vaccine》2022,40(19):2679-2695
Vaccinations are essential for preventing infectious diseases in children with chronic diseases as they have increased risk of infection from frequent use of biologics. Response to immunizations in this group is not well known.ObjectiveA systematic review was performed to evaluate three primary outcomes: efficacy; immunogenicity; and safety of vaccines in children with chronic conditions treated with biologics.MethodsThe protocol for our systematic review and meta-analysis was registered and published with PROSPERO. We searched electronic bibliographic databases for studies published from 2009 to 2019, focusing on vaccinations in children with chronic conditions treated with biologics.ResultsWe retrieved 532 records. Thirty-one full-text articles were selected, and 14 were included in the meta-analysis. No significant publication bias was found. Efficacy: limited data are available regarding the efficacy of vaccination, as most studies have focused on immunogenicity as surrogate outcome for efficacy. Immunogenicity: patients receiving anti-TNF-alpha therapy had a statistically significant risk of poor seroconversion (p = 0.028) and seroprotection by the serotype B influenza vaccine [inflammatory bowel disease (IBD) p = 0.013; juvenile idiopathic arthritis (JIA) p = 0.004]. We found adequate responses with H1N1 and H3N2 serotypes. Few studies existed for pneumococcal, hepatitis A virus, hepatitis B virus, varicella-zoster virus, Measles Mumps Rubella virus, and multiple vaccine administration. Safety: vaccine administration was not associated with serious side effects, but JIA patients on anti-TNF alpha therapy had a statistically significant risk of presenting with myalgia or arthralgia postinfluenza vaccine (p = 0.014).ConclusionsMore evidence concerning efficacy, immunogenicity, and safety of vaccinations is needed to guide physicians in the vaccine decision process for this pediatric population. 相似文献
3.
4.
5.
6.
7.
8.
9.
[摘要] 目的 评估直接抗病毒药物(direct antivirus agent, DAA)治疗肝移植术后HCV感染复发的有效性和安全性。方法?回顾性分析首都医科大学附属北京佑安医院2011年2月—2018年12月收治的14例肝移植术后HCV感染复发患者的DAA治疗临床数据,比较患者基线与治疗结束后肝肾功能、血常规、凝血功能、病毒学水平以及无创纤维化评分天冬氨酸转氨酶血小板比率指数(aspartate aminotransferase-platelet ratio index, APRI)的差异。利用电子病历系统和电话随访收集患者治疗期间不良反应发生情况。结果?所有患者均在治疗结束时达到病毒学清除,12周、24周持续病毒学应答率均为100%,DAA治疗后随访17~44个月,期间均未见病毒学复发。与基线水平相比,治疗终点时ALT、AST、TBIL、γ-谷氨酰转移酶以及无创纤维化评分APRI显著下降,WBC、HGB、PLT、CRE、肾小球滤过率和血糖等指标均未见显著变化。DAA治疗期间共3例患者发生不良反应,均为轻度,可自然缓解。结论?肝移植术后HCV感染复发的DAA治疗是安全有效的。 相似文献
10.
昆虫抗菌肽是昆虫为抵御外界病原微生物感染产生的免疫活性物质的总称,其优异的抗炎活性使其具有广阔的应用前景。综述了不同种类昆虫抗菌肽的抗炎活性及可能涉及的信号通路,介绍了昆虫抗菌肽临床研究现状,以期为昆虫抗菌肽的应用研究提供文献参考。 相似文献