排序方式:
出版年(降序)
出版年(升序)
被引次数(降序)
被引次数(升序)
更新时间(降序)
更新时间(升序)
杂志中文名(升序)
杂志中文名(降序)
杂志英文名(升序)
杂志英文名(降序)
作者中文名(升序)
作者中文名(降序)
作者英文名(升序)
作者英文名(降序)
相关性
共有9条查询结果,搜索用时 15 毫秒
1.
目的比较厄贝沙坦氢溴酸盐与厄贝沙坦的毒性和药效。方法采用无创血压测量比较了厄贝沙坦氢溴酸盐、厄贝沙坦对自发性高血压大鼠血压的影响。分别ip、ig给药,观察两种药物的半数致死量(LD50),对心率、呼吸以及动物自主活动的影响。结果自发性高血压大鼠的血压明显高于非自发性高血压大鼠,给予厄贝沙坦氢溴酸盐、厄贝沙坦后血压均降至正常水平,且两种药物的降压作用差异无显著性,但厄贝沙坦氢溴酸盐的药效持续时间更长。厄贝沙坦氢溴酸盐、厄贝沙坦对动物的呼吸、心率以及自主活动的影响无差异,但厄贝沙坦氢溴酸盐的LD50明显高于厄贝沙坦。结论厄贝沙坦氢溴酸盐具有和厄贝沙坦相同的降压作用,但是作用时间更长,安全性更高。
相似文献
2.
目的探讨Versapulse多波长激光治疗皮肤色素性病变的应用效果。方法选取42例各类皮肤色素性病变病例,应用Versapulse多波长激光治疗仪进行治疗,观查治疗前后的皮肤变化,分析其治疗效果。结果Versapulse波长治疗机对皮肤色素性病变疗效显著,治疗后不留疤痕。结论该机利用“选择性光热作用”原理,将四种波长激光器集于一体,可以较好地完成对各种皮肤色素性疾患的治疗,既满足了治疗疾病的要求又达到了不损伤周围正常组织的目的。
相似文献
3.
克拉维酸钾是重要的β-内酰胺酶抑制剂。本文考察了溶剂种类、晶种、搅拌速率、流加速率、溶液pH值、结晶温度等工艺条件对克拉维酸钾反应结晶过程的影响。在优化工艺条件下,制得粒度较为粗大的棒状克拉维酸钾结晶,平均粒度48.86μm,分散性和流动性良好,产品质量符合中国药典2000年版和美国药典USP24要求。
相似文献
4.
介绍固定化青霉素酰化酶反应器的研究现状,将这类反应器分为搅拌釜反应器、柱式填充床反应器、中空纤维膜反应器以及电渗析耦合反应器,从工程角度分析了各类反应器的优缺点,并展望其今后的发展趋势。
相似文献
5.
氨苄西林钠是全世界第一个应用于临床的广谱半合成青霉素类药物,溶液结晶技术是决定氨苄西林钠产品质量的关键因素.为解决目前氨苄西林钠工业结晶产品聚结、粒度分布不均一等问题,本文提出了氨苄西林钠溶析结晶工艺,考察了晶种的加入量、结晶温度、溶析剂流加速度、表面活性剂对产品的主粒度和粒度分布的影响,实验结果表明晶种加入量为产品初始加入量的0.1%、结晶温度为288K、变速流加溶析剂以及加入十二烷基磺酸钠表面活性剂的条件下,可获得主粒度大、粒度分布均匀的晶体产品.
相似文献
6.
小檗碱(berberine)是一种天然存在的苄基异喹啉类生物碱,具有抗菌、抗癌、降血脂、抗糖尿病和止泻等广泛药理活性,但因其极低的口服生物利用度(<1%),限制了其在临床上的应用,尚无纯小檗碱配方被批准用于任何特定疾病。小檗碱口服生物利用度低主要是由于其在酸性条件下自聚集导致的溶解度差、渗透性低、P-gp(P-glycoprotein)介导的外排和肝肠代谢。提高小檗碱的口服生物利用度可提高小檗碱的药理活性,降低给药剂量进而减少不良反应。本文综述了小檗碱的多种药理活性、代谢过程、药代动力学特征,重点介绍了通过提高溶解度和渗透性、抑制P-gp外排和结构修饰等途径提高小檗碱口服生物利用度的策略,并对小檗碱的研究进行了展望,为其深入研究提供指导。
相似文献
7.
利用头孢羟氨苄N,N-二甲基甲酰胺(DMF)溶剂化物在水溶液中反应结晶得到头孢羟氨苄单水合物晶体,产品往往存在聚结、松紧密度小、粒度分布不均匀、晶习不稳定等问题。本文考察了结晶过程中温度、搅拌速率、溶剂配比、溶液pH值等因素对产品粒度分布、晶习及晶体聚结的影响。研究结果表明,结晶温度对产品粒度、晶习和晶体聚结都有影响,搅拌速率和溶剂配比主要影响产品的粒度分布。实验优化得到了头孢羟氨苄单水合物反应结晶的最佳操作工艺并为工业化生产提供了重要的参考价值,利用该工艺得到的头孢羟氨苄单水合物产品为四方片状晶体、晶习完整、粒度分布均匀、产品不聚结,松紧密度分别为0.37g/mL和0.57g/mL,产品质量达国际水平。
相似文献
8.
头孢羟氨苄是重要的头孢类抗生素。为提高产品的质量和收率,本文对目前工业上采用的间接法反应结晶制备工艺进行了优化,得到了经验最佳操作时间表;同时,研究了有较大发展潜力的直接法结晶生产头孢羟氨苄工艺,解决了该工艺中严重的“结胨”问题.为后续相关研究提供了思路。
相似文献
9.
Shah R B,Tawakkul M A,Khan M A.Process analytical technology:Chemometric analysis of Raman and near infrared spectroscopic data for predicting physical properties of extended release matrix tablets[J].J Pharm Sci,2007,96(5):1356-1365.
Mafalda Cruz Sarraguc,Joao Almeida Lopes.Quality control of pharmaceuticals with NIR:From lab to process line[J].Vibr Spec,2009,49(2):204-210.
Zidan A S,Habib M J,Khan M A.Process analytical technology:Nondestructive evaluation of cyclosporine A and phospholipid solid dispersions by near infrared spectroscopy and imaging[J].J Pharm Sci,2008,97(8):3388-3399.
El-Hagrasy A S,Delgado-Lopez M,Drennen J K.A process analytical technology approach to near-infrared process control of pharmaceutical powder blending:Part Ⅱ:Qualitative near-infrared models for prediction of blendhomogeneity[J].J Pharm Sci,2006,95(2):407-421.
Pollanen K,Hakkinen A,Reinikainen S P,et al.IR spectroscopy together with multivariate data analysis as a process analytical tool for in-line monitoring of crystallization process and solid-state analysis of crystalline product[J].J Pharm Biomed Anal,2005,38(2):275-284.
O' Brien L E,Timmins P,Williams A C.Use of in situ FT-Raman spectroscopy to study the kinetics of the transformation of carbamazepine polymorphs[J].J Pharm Biochera Anal,2004,36(2):335-340.
Savolainen M,Kogermann K,Heinz A,et al.Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy[J].Europ J Pharm Biopharm,2009,71(1):71-79.
Yu Q Z,Chou P S,Tan R B H.Application of attenuated total reflectance-fourier transform infrared technique in the monitoring and control of anti-solvent crystallization[J].Ind Eng Chem Res,2006,45(1):439-444.
Chen Z P,Morris J,Borissova A,et al.On-line monitoring of batch cooling crystallization of organic compounds using ATR-FTIR spectroscopy coupled with an advanced calibration method[J].Chemometr Intell Lab Syst,2009,96(1):49-58.
Matthews H B.Model identification and control of batch crystallization for an industrial chemical system[D].Ph.D.Thesis,University of Wisconsin,1997.
Scholl J,Bonalumi D,Lars Vicum,et al.In situ monitoring and modeling of the solvent-mediated polymorphic transformation of L-glutamic acid[J].Cryst Grow Des,2006,6(4):881-891.
张延会,吴良平,孙真荣.拉曼光谱技术应用进展[J].化学教学,2006,4:32-35.
Sulub Y,Lo Brutto R,Vivilecchia R,et al.Content uniformity determination of pharmaceutical tablets using five near-infrared reflectance spectrometers:A process analytical technology(PAT)approach using robust multivariate calibration transfer algorithms[J].Aanal Chim Acta,2008,611(2):143-150.
Hansman D S,Cambron R T,Sakr A.Application of online Raman spectroscopy for characterizing relationships between drug hydration state and tablet physical stability[J].Intern J Pharm,2005,299:19-33.
Fevotte G.In situ raman spectroscopy for in-line control of pharmaceutical crystallization and solids elaboration processes:A review[J].Chem Eng Res Des,2007,85(A7):906-920.
Tian F,Qu H,Louhi-Kultanen M,et al.Mechanistic insight into the evaporative crystallization of two polymorphs of nitrofurantoin monohydrate[J].J Cryst Growth,2009,311(8):2580-2589.
Xiang-Shan Li,Jie-Xin Wang,Zhi-Gang Shen,et al.Preparation of uniform prednisolone microcrystals by a controlled microprecipitation method[J].Intern J Pharm,2007,342(1-2):26-32.
Hu Y,Wikstrom H,Byrn S R,et al.Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy[J].J Pharm Biomed Anal,2007,45(4):546-551.
Starbuck C,Spartalis A,Wai L,et al.Process optimization of a complex pharmaceutical polymorphic system via in situ raman spectroscopy[J].Cryst Growth Des,2002,2(5):515-522.
Seefeldt K,Miller J,Alvarez-nunez F,et al.Crystallization pathways and kinetics of carbamazepine-nicotinamide cocrystals from the amorphous state by in situ thermomicroscopy,spectroscopy and calorimetry studies[J].J Pharm Sci,2007,96(5):1147-1158.
范少杰.太赫兹技术概述及其应用[J].电光系统,2008,2:62-64.
Wu H,Heilweil E J,Hussain A S,et al.Process analytical technology(PAT):Effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets[J].Intern J Pharm,2007,343(1-2):148-150.
Liu H,Chen Y,Zhang X C.Characterization of anhydrous and hydrated pharmaceutical materials with thz time-domain spectroscopy[J].J Pharm Sci,2007,96(4):927-934.
Fischer B,Hoffmann M,Helm H,et al.Chemical recognition in terahertz time-domain spectroscopy and imaging[J].Seraicond Sci Technol,2005,20(7):S246-S253.
Strachan C J,Taday P F,Newnham D A,et al.Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity[J].J Pharm Sci,2005,94(4):837-846.
Gvishi R,Englander A,Peleg G.Multi-parameter evaluation of fast sol-gel process by terahertz measurements[J].J Sol Gel Sci Technol,2008,48(1-2):18-23.
胡永生,陈钱.太赫兹技术及其应用研究的进展[J].红外,2006,27(1):11-15.
张兴宁,陈稷,周泽魁.太赫兹时域光谱技术[J].激光与光电子学进展,2006,42(7):35-38.
X射线衍射分析的实验方法及其应用[OL].http://www.ms17.cn/jszx/2008/0321/article 852.html.
Blagden N,Davey R,Song M,et al.A novel batch cooling crystallizer for in situ monitoring of solution crystallization using energy dispersive X-ray diffraction[J].Cryst Growth Des,2003,3(2):197-201.
Pyne A,Suryanarayanan R.The effect of additives on the crystallization of cefazolin sodium during freeze-drying[J].Pharm Res,2003,20(2):283-291.
Pyne A,Surana R,Suryanarayanan R.Crystallization of mannitol below Tg during freeze-drying in binary and ternary aqueous systems[J].Pharm Res,2002,19(6):901-908.
Pyne A,Suryanarayanan R.Phase transitions of glycine in frozen aqueous solutions and during freeze-drying[J].Pharm Res,2001,18(10):1448-1454.
Davis T D,Morris K R,Huang H,et al.In situ monitoring of wet granulation using online X-ray powder diffraction[J].Pharm Res,2003,20(11):1851-1857.
杨传铮,汪保国,张建.二维X射线衍射及其应用研究进展[J].物理学进展,2007,27(1):69-81.
Cooke P M.Chemical microscopy[J].Anal Chem,2000,72(12):169-188.
Matthews H,Rawlings J.Batch crystallization of a photochemical:modeling,control,and filtration[J].AICHE J,1998,44(5):1119-127.
Mirza S,Heinamaki J,Miroshnyk I,et al.Understanding processing-induced phase transformations in erythromycin-PEG 6000 solid dispersions[J],d Pharm Sci,2006,95(8):1723-1732.
Fielden I M,Rodenburg J M.A technique for real-time,in situ SEM observation of grain growth at elevated temperatures[J].Recrystal Grain Growth,Pts 1 and 2,2004,467-470:1385-1388.
P.Mura,M.T.Faucci,A.Manderioli,et al.Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry,hot-stage microscopy and scanning electron microscopy[J],J Pharm Biomed Anal,1998,18(1-2):151-163.
Bikiaris D,Papageorgiou G Z,Stergiou A,et al.Physicochemical studies on solid dispersions of poorly watersoluble drugs Evaluation of capabilities and limitations of thermal analysis techniques[J].Thermochimica Acta,2005,439(1-2):58-67.
Krumme A.Measuring crystallization kinetics of high density polyethylene by improved hot-stage polarized light microscopy[J].Polymer Testing,2004,23(1):29-34.
Yu Z Q,Tan R B H,Chow P S.Effects of operating condition on agglomeration and habit of paracetamol crystal in anti-solvent crystallization[J],d Cryst Growth,2005,279(3-4):477-488.
Sheikhzadeha M,Trifkovica M,Rohani S.Real-time optimal control of an anti-solvent isothermal semi-batch crystallization process[J].Chem Eng Sci,2008,63(3):829-839.
Kougoulos E,Jones A G,Wood-kaczmar M W.Estimation of crystallization kinetics for an organic fine chemical usinga modified continuous coolingmixed suspension mixed product removal(MSMPR)crystallizer[J],d Cryst Growth,2005,273(3-4):520-528.
Dang L,Wei H,Zhu Z,et al.The influence of impurities on phosphoric acid hemihydrate crystallization[J].J Cryst Growth,2007,307(1):104-111.
O'Sullivan B,Barrett P,Hsiao G,et al.In situ monitoring of polymorphic transitions[J].Org Proc Res Dev,2003,7(6):977-982.
Kougoulos E,Jones A G,Wood-Kaczmar M W.Modelling particle disruption of an organic fine chemical compound using Lasentec focussed beam reflectance monitoring(FBRM)in agitated suspensions[J].Power Technol,2006,155(2):153-15.
Barrett P,Glennon B,O' Sullivan B.Solubility Curve and Metastable Zone Width Using Lasentec FBRM and PVM[J],Chemi Eng,2002,80(A7):799-805.
Doki N,Seki H,Takano K.Process control of seeded batch cooling crystallization of the metastable α-form glycine using an in-situ ATR-FTIR spectrometer and an in-situ FBRM particle counter[J].Cryst Growth Des,2004,4(5):949-953.
张海涛.头孢噻肟钠结晶技术研究[D].天津大学,2008.
谌怡.克林霉素磷酸酯结晶过程研究[D].天津大学,2008.
武洁花.头孢唑林钠结晶过程研究[D].天津大学,2008.
苏敏.直通法生产6-APA系统过程研究[D].天津大学,2009.
王永莉.头孢哌酮钠间歇结晶过程优化研究[D].天津大学,2009.
王占忠.红霉素结晶过程研究[D].天津大学,2007.
>>更多 ... 相似文献