慢性精神分裂症患者运用合理沟通的治疗效果观察

目的：探讨慢性精神分裂症患者运用合理沟通的治疗效果。方法：研究我院2013年6月至2015年11月期间诊治的80例慢性精神分裂症患者，分为对照组和观察组各40例，对照组应用常规药物治疗，观察组在对照组基础上添加合理沟通治疗，分析两组患者治疗效果差异。结果：在1至2年的复发率上，观察组均低于对照组，两组差异具有统计学意义，p<0.05；在治疗前后患者焦虑、抑郁和康复疗效量表评分上，观察组改善幅度高于对照组，两组差异具有统计学意义，p<0.05。结论：慢性精神分裂症患者运用合理沟通可以提升治疗效果，改善患者精神状态。     

Simultaneous Determination of Six Compounds in Rat Plasma by Ultra‑Performance Liquid Chromatography with Tandem Mass Spectrometry: Application in the Pharmacokinetic Study of Qing Gan‑Shu Yu‑Fang

A rapid and high selective ultra?performance liquid chromatography (UPLC) with tandem mass spectrometry method for simultaneous determination of six compounds including albiflorin, paeoniflorin, picroside I, picroside II, saikosaponin A, and saikosaponin D in rat plasma was developed and validated using butyl p-hydroxybenzoate as an internal standard. One-step direct protein precipitation with acetonitrile was used to extract the compounds from the rat plasma samples. Chromatographic separation was achieved using an ACQUITY UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 µm) at a flow rate of 0.4 mL/min, using gradient mode containing 0.1% formic acid in water and acetonitrile were used as the Mobile phase A and B. Electrospray ionization in negative ion mode and multiple reaction monitoring were used to identify and quantify active components. Calibration curves showed good linearity (R2 > 0.9908) over a wide concentration range for all compounds. The intra- and interday precision (relative standard deviation) ranged 2.4%–7.0% and 2.6%–8.0%, respectively. The accuracy (relative error) was from ?13.0% to 13.2% at all quality control levels. The recovery ranged from 81.1% to 92.5%. The validated method was successfully applied to pharmacokinetic study in rats after oral administration of Qing Gan?Shu Yu?Fang. The results show that one can draw a conclusion that these six active ingredients can be quickly absorbed and play a pharmacodynamic role rapidly in vivo.     

Analysis of brain-stem auditory evoked potential and visual evoked potential in patients with Parkinson disease

INTRODUCTION The exact cause of Parkinson disease (PD) has not been known yet[1]. The overwhelming progress had been made in the treatment and pathogenesis of PD in recent 30 years, especially 10 years[2]. But it is still no way now to prevent or postpone…     

外部性脑积水的CT诊断与临床

目的：探讨婴儿外部性脑积水的CT诊断与临床治疗及预后。方法：收集回顾资料完整且经CT及临床明确诊断的15例外部性脑积水，男11例，女4例，发病年龄2—6个月8例，8-10个月5例，10个月以上2例，全部经CT平扫检查。结果：婴儿外部性脑积水CT特征为：双侧额顶部蛛网膜下腔增宽（≥5mm）．前部纵裂池增宽（≥6mm），大脑外侧裂池增宽（≥7mm），额顶部脑沟增宽增深。鞍上池扩大，双侧脑室轻度扩大或不大；临床有婴儿短期内头围异常增大、前囟膨隆、一过性惊厥、烦躁哭闹等症状。结论：外部性脑积水一般预后良好，多数无须临床特殊干预：部分继发性外部脑积水应给予积极对症治疗。CT对外部性脑积水的临床诊断、病程观察及指导治疗具有重要价值。     

在改革中发展乡镇卫生院

改革是竞争的产物,发展是改革的目的,社会经济发展要求乡镇卫生院同步实现现代化,社会医疗卫生保健服务的新形势需要乡镇卫生院的现代化,如何在改革中发展乡镇卫生院,使之能够满足人们日益增长的医疗保健需求,保证其在社区卫生服务中的主导地位,是改革浪潮中摆在我们面前的重要课题。     

发作性运动诱发性舞蹈手足徐动症（附11例报告）

发作性运动诱发性舞蹈手足徐动症(PKC)是一种少见的以发作性运动障碍为主的神经科疾病,现将笔者对11例PKC患者的诊治情况报告如下。11例患者,男∶女=9∶2,年龄11～27岁,起病6～18岁,病程3个月～17年。有PKC家族史1例,癫家族史1例,自身合并癫(全身强直阵挛发作)1例临床表现:     

首次头颅CT正常的脑出血病人临床分析

病例1女，25岁。1992年5月因其父病重由外地回家探亲，回家当晚突感剧烈头痛，伴恶心6h。来我院行头部CT检查结果正常。查体：神清，血压正常，无明显神经系统定位体征。门诊予以对症处理，症状稍减轻。次日中午再次感头痛加重、抽搐、昏迷，转送我院头颅CT复查：左侧基底节大量出血，中线移位，侧脑室受压，检查双侧瞳孔散大，对光反射消失、呼吸衰竭，经抢救无效死亡。     

中医医院病理科现状与对策

随着医学科学的发展,对疾病的诊断手段日益增多,但是迄今为止即使世界上科学技术最发达的国家对疾病的诊断还是通过病理诊断.病理诊断是医院诊断服务中的中心工作,其水平直接关系到医院的诊治水平.一个医院病理诊断水平是医院医疗质量的最重要指标之一.要想搞好病理诊断质量,病理科的建设和工作人员的组成十分重要.中医院的病理科建设较晚,目前存在的问题较多.笔者走访数十家各级中医院病理科,水平参差不齐,现状堪忧.总结如下.……