Neural changes after Emotional Freedom Techniques treatment for chronic pain sufferers

This clinical trial investigated the effect of an Emotional Freedom Techniques (EFT) intervention on brain activation in chronic pain sufferers using functional magnetic resonance imaging (fMRI). EFT is a brief stress reduction technique which combines stating a cognitive statement with somatic tapping on acupressure points. Twenty-four adults were allocated to a six-week online group EFT treatment and underwent resting-state fMRI pre and post the intervention. A repeated measures MANOVA indicated significant differences in the levels of pain severity (−21%), pain interference (−26%), quality of life (+7%), somatic symptoms (−28%), depression (−13.5%), anxiety (−37.1%), happiness (+17%), and satisfaction with life (+8.8%) from pre-to post-test. Cohen's effect sizes ranged from small (0.2) to large (0.75) values suggesting significance for the intervention. fMRI analysis showed post-EFT treatment significantly decreased connectivity between the medial prefrontal cortex (a pain modulating area) and bilateral grey matter areas in the posterior cingulate cortex and thalamus, both areas being related to modulating and catastrophizing of pain. There were no brain areas that showed significantly increased connectivity post-EFT treatment. Coupled with the psychological measures the findings support the effects of the EFT intervention in reducing chronic pain and its impacts. Recommendations for future research are discussed.     

淋病疫苗研制的必要性与可行性

淋病是一种常见的性传播疾病,其致病菌为淋病奈瑟球菌,其已经对多种抗生素产生了不同程度的耐药,尤其是对头孢菌素高度耐药。随着淋病在世界范围内发病率的持续上升,以及耐药性的增加,其会严重影响欠发达地区的生殖健康。因此,疫苗的研制对控制淋病奈瑟球菌感染至关重要。本研究阐述了淋病对成人和新生儿的影响,强调了疫苗的研制对淋病治疗的必要性和可行性。     

情景模拟健康教育对白内障患者术中配合知识认知度及应激反应的影响

目的研究情景模拟健康教育对白内障患者术中配合知识认知度及应激反应的影响。方法选取2018年1月至2019年1月在南京医科大学附属无锡第二医院接受白内障手术的患者88例作为对象,依据随机数字表法,将其分为A组和B组,各44例。A组采用情景模拟健康教育,B组采用常规健康教育方式。比较两组在健康教育前后的配合知识认知度评分、焦虑自评量表(SAS)、抑郁自评量表(SDS)、视觉模拟评分量表(VAS)及健康教育前后的血流动力学指标(包括收缩压、舒张压及心率)。结果健康教育后,A组健康教育的配合知识认知度评分高于B组,A、B两组SAS评分分别为(37.44±5.12)分、(45.55±5.16)分,A组低于B组;A、B两组SDS评分分别为(34.52±4.21)分、(39.37±4.32)分,A组低于B组;A、B两组VAS评分分别为(1.11±0.61)分、(2.67±0.65)分,A组低于B组;A组的收缩压、舒张压及心率均低于B组,差异均有统计学意义(均P<0.05)。结论对白内障患者采用情景模拟健康教育,不仅能够提高其术中配合知识的认知度,还能够缓解其应激反应。     

三维有限元动态分析不同螺距的两种螺纹种植体的应力分布

目的：研究有无防沉装置的两种种植体不同螺距的应力分布及力学相容性。方法：采用三维有限元动态分析法,以ＳｕｐｐｅｒＳＡＰ９３程序在周期为０．８ｓ的正弦半波力作用下对两种种植体进行应力分析,Ａ组无防沉装置,Ｂ组有防沉装置。结果：无效沉装置者应力分布较均匀,有防沉装置者骨平面处应力相对集中,适当增大螺距可分散该处的应力。结论：无防沉装置的设计较有防沉装置者应力分布更均匀。     

不同长度和直径桩核的三维光弹性应力分析

目的 对比不同长度和直径的桩核受力后应国分布情况。方法 根据桩的长短、粗细胞将实验分成四组,通过垂直和斜向加载,采用三维光弹性应力冻结法,经模型切片观察计算出模型各测点的最大剪应力。结果 桩的直径增加根尖区最大剪应力相应增高,桩核交界处和核与根面交界面最大剪应力的明显增高。桩的长度增加,应力分布更为均匀。结论 从抗力固位角度出发有一定和蔗的粗细合适的柱形桩核较为理想。     

Autoantibodies to the heat-shock protein hsp73 in localized scleroderma

We determined the presence of antibodies to the heat-shock protein hsp73 (anti-hsp73) in 57 serum samples from patients with localized scleroderma using an enzyme-linked immunosorbent assay (ELISA). In addition, 30 samples from healthy individuals, 30 from patients systemic lupus erythematosus (SLE) and 32 from patients with systemic sclerosis were assessed. IgG and/or IgM anti-hsp73 antibodies were detected in 33% (19/57) of the patients with localized scleroderma. Among the three subtypes of localized scleroderma, generalized morphoea showed the highest incidence of anti-hsp73 antibodies (40%, 6/15). IgG and/or IgM anti-hsp73 antibodies were also detected in 9/30 samples (30%) from patients with SLE and in 13/32 samples (41%) from patients with systemic sclerosis, while the samples from the healthy controls were all negative for anti-hsp73. By immunoblotting, specific binding of antibodies to hsp73 was confirmed with representative serum samples that were positive for anti-hsp73 in the ELISA. Our findings indicate that the presence of anti-hsp73 is an additional immunological abnormality in localized scleroderma.     

高压氧对大鼠减压损伤时脑和肝胞液糖皮质激素受体的影响

目的 探讨高压氧对动物减压损伤的治疗效用。方法 大鼠18只,随机分为3组,清醒状态置于加压舱内,进行加、减压实验,造成急性减压损伤。高压氧治疗组动物形成减压损伤后随即再置于小型高压氧舱内,在250kPa高压氧暴露60min。出舱后进行脑和肝胞液糖皮质激素受体结合量的检测。结果 动物出现减压损伤后,脑和肝胞液糖皮质激素受体结合量分别比对照组减少25％和16．4％,尤其以脑胞液糖皮质激素受体结合量可比高压氧暴露前分别回升9．5％和9．2％,动物一般状态亦随之好转。结论（1）快速减压时可引起动脉脑和肝胞液粮皮质激素受体结合量明显减少,并造成动物病理性应激反应;（2）高压氧暴露对减压损伤所致的糖皮质激素受体代谢具有调整作用。     

严重创伤后应激反应的调控机理

Traumatic stress in the normal individual results in activation of the sympatho - adrenal system caus-ing a rise in noradrenaline and adrenaline, acute phase response in liver , and activation of the hypothalamic - pituitary -adrenocortical(HPA)system resulting in elevated levels of cortisol. Studies in animals and in humans with posttraumatic stress disorder indicate that successful adaptation to stress is a prerequisite for the survival of all organisms living in an enviroment in which noxious stimuli are constantly present.     

粘性流体在弯曲管道内在交变压力梯度下的振荡流动

在血液动力学中,一般只有在微血管中才可把血液运动近似看作定常运动,而在大动脉或动脉中,血液的压力在同一位置上是随时间周期性变化的.考虑到血管具有一定的弯曲度,本文引入了一种新的坐标系统,解决了弯管中的振荡流问题.给出了流体在弯管中运动的速度及切应力公式,并对切应力加以讨论.发现微弯管中的切应力将在壁面上获得极值.本文还通过计算机计算,得知流体对弯管两侧的冲刷力也是振荡的.并且随着压力差的增大,流体对弯管两侧的冲刷力的差值也增大;随着曲率的减小,此差值也减小.此结果较好地解释了动脉硬化形成的主要原因切应力的影响.对于进一步深入了解血液在血管中的流动,特别是血液在弯曲大动脉内流动特性的研究提供了理论依据.     

烧伤病人出院前心理压力源及应对方式的调查研究

对出院前的60例成年烧伤病人所面临的心理压力源、压力及压力应对方式进行调查分析.结果显示出院前的烧伤病人面临自身与环境双重压力源,并有轻度的心理压力,外貌的改变和别人的歧视与偏见分别是来自自身和环境的首要压力源.所有病人均采用问题取向和情感取向两种压力应对方式,但81.7%的病人偏重于问题取向的压力应对方式,而18.3%的病人偏重于情感取向的压力应对缓解心理压力,侧重于问题取向的压力应对方式的病人比侧重于情感取向的病人有较低的心理压力(P＜0.05).此结果为制定烧伤病人出院前后心理康复计划提供了指导依据.