胸腺瘤合并低钾周期性麻痹２例

2009年我院收治了2例胸腺瘤合并低钾周期性麻痹的患者,行胸腺瘤切除术后低钾周期性麻痹均得到明显缓解,考虑胸腺瘤与低钾周期性麻痹之间可能存在一定的联系,现将2例诊治情况报告如下。     

周期性张应力诱导成纤维细胞凋亡中p38MAPK信号通路的作用

背景：当牙齿受异常咬合力时会导致牙体吸收、牙周组织的大量破坏。 目的：研究牙周膜成纤维细胞在受到周期性张应力刺激后是否发生凋亡及p38MAPK信号通路是否参与该凋亡过程。 方法：取4~7代成纤维细胞,同步化后随机分为对照组、加力组和SB203580组。加力组和SB203580组细胞加载力值为12%表面应变率,加力频率为6个循环/min,即5 s拉伸,5 s松弛。SB203580组细胞在加力前1 h加入终浓度为20 mmol/L的p38MAPK抑制剂SB203580。分别在加力6,12,24 h,取各组细胞,流式细胞仪检测细胞凋亡,RT-PCR检测细胞凋亡基因bax mRNA的表达。 结果与结论：与对照组比较,加力后成纤维细胞凋亡率及bax mRNA表达增加 (P < 0.05),且随着加力时间的延长而增强,12 h达高峰,之后逐渐下降。与加力组比较,SB203580组对应时间点细胞凋亡减少 (P < 0.05),bax mRNA表达降低。说明细胞受到力学刺激会发生凋亡,而丝裂原活化蛋白激酶p38MAPK信号通路参与了该凋亡过程。     

周期性电生理信号一种融合方法的研究

提出了传感器获取的周期性电生理信号按周期进行同步后得到多周期数据,构建周期性时间数据序列进行融合计算的方法,以实测心电信号对该方法的有效性进行了验证,同时提高了电生理信号信息特征获取的效果。     

以周期性麻痹为首发症状的甲亢误诊1例

甲亢周期性麻痹是甲亢患者的神经肌肉并发症,有时可能是甲亢患者的首发症状和就诊原因,故易忽视甲亢的临床症状,导致甲亢的误诊、漏诊.现将1例以周期性麻痹为首发症状的甲亢病例误诊报告如下,以供参考.     

11例周期性呕吐综合征患儿的护理

周期性呕吐综合征（cyclic vomiting syndrome,CVS）又称再发性呕吐综合征（recurrent vomiting syndrome）,是主要发生在儿科年龄段的功能性胃肠道疾病,其特点是≥3次的发作性顽固性的恶心、呕吐,每次发作持续数小时至数日,两次发作间有长达数周至数月的完全无症状间歇期,患儿不存在任何代谢、神经、消化等系统的异常。CVS患儿发作期非常衰弱、倦怠,严重影响生活和学习。     

经腹经直肠超声联合应用诊断处女膜闭锁六例分析

一、资料与方法 1998年10月至2009年2月因不同程度逐渐加剧的周期性下腹痛初次来我院内外科就诊的未婚女患者6例,年龄12—17岁,中位年龄14岁。     

^131I治疗甲亢604例近期疗效分析

目的分析^131I治疗甲亢近期临床疗效。方法根据甲状腺质量和最高吸碘率等给予604例甲亢患者个性化^131I治疗,^131I于治疗后1、3、6、12个月随访,对甲亢、Graves眼病、甲亢性心脏病、低钾周期性麻痹、谷丙转氨酶升高、粒细胞减少及甲状腺大小等的转归进行回顾性分析。结果痊愈374例（61．9％）,部分缓解101例（16．8％）,甲减112例（18．5％）,无效17（2．8％）,总有效率为97．2％,治愈率为80．4％。^131I治疗Graves眼病总有效率83．7％,治疗甲亢性心脏病总有效率95．6％,同时可以缓解低钾周期性麻痹症状,改善肝功能,升高粒细胞,缩小甲状腺。结论^131I治疗甲亢及其伴发症安全有效,但要注意甲减等并发症的发生。     

不宁腿综合征是卒中的危险因素

正不宁腿综合征(restless legs syndromeRLS)是临床常见的病因不明的感觉运动障碍性疾病,特征是小腿不适感或感觉异常,伴活动小腿的强烈愿望,也称为胫部不宁性焦虑(anxietastibiarum),常描述为一种深部的异常痛苦的、跳动的、烧灼样、蠕动样、挤压样撕裂样疼痛,症状呈昼夜规律变化,在夜间睡     

克莱恩-莱文综合征一例北大核心CSCD

临床资料 患者男,30岁,已婚.因“反复周期性嗜睡1年余”于2017年5月16日收入北京大学第六医院住院.2016年患者劳累后出现头晕、困倦,逐渐出现嗜睡,就诊当地某综合医院急诊,入院后患者一直处于睡眠中,偶有四肢抖动,反复摇晃或呼唤姓名均不能将其唤醒.无跌倒、梦游、梦呓、大小便失禁、抽搐等表现。     

周期性牵张椎间盘纤维环细胞肌动蛋白骨架的重排

BACKGROUND: When the intervertebral disc is under stress, the hydraulic pressure generated inside the nucleus pulposus makes the annulus fibrosus extend outward and expand, and the annulus collagen fibers are stretched so that the extracellular matrix of annulus fibrosus cells is also under the pressure. In the intervertebral disc, aggrecan is the main component of proteoglycans, matrix metalloproteinase-2 is a major enzyme for extracellular matrix degradation, and tissue inhibitor of metalloproteinase is a multifunctional specific inhibition factor for matrix metalloproteinase activity. There is a mutual regulation between the latter two to keep the homeostasis between them. OBJECTIVE: To investigate the mechanism of cyclic tensile strain in the metabolism of intervertebral disc annulus matrix. METHODS: Rat anulus fibrosus cells were subjected to 2% or 10% cyclic tensile strain at 1.0 Hz for 2 and 12 hours using Flexcell4000 tension system. Then cells were collected and cultured in conditioned medium for gene and protein detection. Real-time quantitative PCR was used to detect mRNA expression of aggrecan, matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2. Gelatin zymography was used to detect matrix metalloproteinases-2 activity. RESULTS AND CONCLUSION: The use of 2% cyclic tensile strain had no obvious effect on the stress fiber of actin cytoskeleton, whereas actin cytoskeleton was depolymerized in response to 10% cyclic tensile strain. The 2% cyclic tensile strain raised the expression of Aggrecan at 12 hours; whereas raised the matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 at 2 hours, both of which were in homeostasis; matrix metalloproteinases-2 activity had no significant changes. 10% cyclic tensile strain had no effect on the mRNA expression of Aggrecan. No matter stretching 2 or 12 hours, the matrix metalloproteinases-2 was up-regulated, and the tissue inhibitor of metalloproteinase-2 was down-regulated, both of which were not in balance. Moreover, the matrix metalloproteinases-2 activity was not significantly changed. These findings indicate that the mRNA expressions of Aggrecan, matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 alter in response to cyclic tensile strain in rat anulus fibrosus cells, and the tensile strain induces different mechano-responses in the actin cytoskeleton.