全文获取类型
收费全文 | 201645篇 |
免费 | 19385篇 |
国内免费 | 7502篇 |
专业分类
耳鼻咽喉 | 1220篇 |
儿科学 | 4605篇 |
妇产科学 | 2909篇 |
基础医学 | 37967篇 |
口腔科学 | 3896篇 |
临床医学 | 12831篇 |
内科学 | 33664篇 |
皮肤病学 | 3308篇 |
神经病学 | 16257篇 |
特种医学 | 3770篇 |
外国民族医学 | 62篇 |
外科学 | 14445篇 |
综合类 | 25260篇 |
现状与发展 | 31篇 |
预防医学 | 8911篇 |
眼科学 | 2417篇 |
药学 | 28351篇 |
25篇 | |
中国医学 | 7415篇 |
肿瘤学 | 21188篇 |
出版年
2024年 | 158篇 |
2023年 | 3019篇 |
2022年 | 3943篇 |
2021年 | 7629篇 |
2020年 | 7165篇 |
2019年 | 8037篇 |
2018年 | 7610篇 |
2017年 | 7640篇 |
2016年 | 7558篇 |
2015年 | 8819篇 |
2014年 | 12763篇 |
2013年 | 14927篇 |
2012年 | 13283篇 |
2011年 | 15398篇 |
2010年 | 13006篇 |
2009年 | 12282篇 |
2008年 | 11538篇 |
2007年 | 10127篇 |
2006年 | 9141篇 |
2005年 | 7784篇 |
2004年 | 6794篇 |
2003年 | 5752篇 |
2002年 | 4429篇 |
2001年 | 3770篇 |
2000年 | 3076篇 |
1999年 | 2659篇 |
1998年 | 2049篇 |
1997年 | 1928篇 |
1996年 | 1592篇 |
1995年 | 1598篇 |
1994年 | 1397篇 |
1993年 | 1177篇 |
1992年 | 980篇 |
1991年 | 881篇 |
1990年 | 728篇 |
1989年 | 619篇 |
1988年 | 527篇 |
1987年 | 428篇 |
1986年 | 432篇 |
1985年 | 872篇 |
1984年 | 938篇 |
1983年 | 653篇 |
1982年 | 743篇 |
1981年 | 559篇 |
1980年 | 480篇 |
1979年 | 408篇 |
1978年 | 306篇 |
1977年 | 251篇 |
1976年 | 232篇 |
1975年 | 168篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
Jeff Unger MD Dale C. Allison MD Margit Kaltoft MD Kavitha Lakkole MBA Jayant K. Panda MD Chethana Ramesh MSc Mehmet Sargin MD Elena Smolyarchuk MD Melissa Twine BS Benjamin Wolthers MD Gizem Yarimbas MSc Marouan Zoghbi MD the LIRA-PRIME investigators 《Diabetes, obesity & metabolism》2022,24(2):204-211
93.
94.
95.
Marc Evans MD Susanne Engberg MD Mads Faurby MSc João Diogo Da Rocha Fernandes MSc Pollyanna Hudson MSc William Polonsky PhD 《Diabetes, obesity & metabolism》2022,24(3):377-390
We designed a systematic literature review to identify available evidence on adherence to and persistence with antidiabetic medication in people with type 2 diabetes (T2D). Electronic screening and congress searches identified real-world noninterventional studies (published between 2010 and October 2020) reporting estimates of adherence to and persistence with antidiabetic medication in adults with T2D, and associations with glycaemic control, microvascular and/or macrovascular complications, hospitalizations and healthcare costs. Ninety-two relevant studies were identified, the majority of which were retrospective and reported US data. The proportions of patients considered adherent (median [range] 51.2% [9.4%-84.3%]) or persistent (median [range] 47.7% [16.9%-94.0%]) varied widely across studies. Multiple studies reported an association between greater adherence/persistence and greater reductions in glycated haemoglobin levels. Better adherence/persistence was associated with fewer microvascular and/or macrovascular outcomes, although there was little consistency across studies in terms of which outcomes were improved. More adherent and more persistent patients were typically less likely to be hospitalized or to have emergency department visits/admissions and spent fewer days in hospital annually than less adherent/persistent patients. Greater adherence and persistence were generally associated with lower hospitalization costs, higher pharmacy costs and lower or budget-neutral total healthcare costs compared with lower adherence/persistence. In conclusion, better adherence and persistence in people with T2D is associated with lower rates of microvascular and/or macrovascular outcomes and inpatient hospitalization, and lower or budget-neutral total healthcare expenditure. Education and treatment strategies to address suboptimal adherence and persistence are needed to improve clinical and economic outcomes. 相似文献
96.
《Saudi Pharmaceutical Journal》2022,30(6):669-678
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction. 相似文献
97.
98.
《Clinical lung cancer》2022,23(2):122-134
Introduction: Both pembrolizumab (P) as a monotherapy or in combination with platinum-based chemotherapy (PCT) represent standard first-line treatment options for advanced non-small cell lung cancer (aNSCLC) with PD-L1 tumor proportion score (TPS)≥50%. No predictive biomarkers exist to guide treatment decisions.Methods: 423 consecutive patients with EGFR/ALK/ROS1-wild-type PD-L1 TPS≥50% aNSCLC receiving P (n = 302) or PCT (n = 121) as a first-line treatment were identified in the electronic databases of 5 Israeli cancer centers. Overall survival (OS, months [mo]) was assessed in correlation with blood biomarkers (BB: NLR, dNLR, PLR, SII, LIPI, ALI); a predictive score was developed.Results: In the propensity score matching analysis (n = 236; 118 patients in each group matched for age, sex and ECOG PS), mOS was 17.2mo (95% CI, 13.2-36.5) and 21.3mo (95% CI, 14.8-NR) in groups P and PCT, respectively (P = .44). In group P, NLR, dNLR, PLR, LIPI, and ALI significantly correlated with OS in uni- and multivariate COX regression analyses (P < .05), whereas in group PCT, none of the BB demonstrated a significant correlation. A predictive score was developed (each parameter receiving one point): age≥65, female sex, never-smoking status, adenocarcinoma histology, dNLR≥3. In patients with predictive score 3-5, OS was significantly longer with PCT as compared to P: mOS NR (95% CI, 15.3-NR) and 8.7mo (95% CI, 5.8-13.7) (P = .0005), while OS didn't differ significantly in patients with predictive score 0-2 (P = .61).Conclusion: With the limitations of the retrospective analysis, the proposed dNLR-based score appears to predict OS with P and PCT. 相似文献
99.
100.