Clinical outcome of adjuvant radiotherapy for squamous cell carcinoma of the breast; a multicenter retrospective cohort study

BackgroundBecause primary squamous cell carcinoma (SCC) of the breast is a rare disease, the standard therapy has not been established. We examined the clinical outcomes of postoperative adjuvant radiotherapy for breast SCC.Material and methodsWe conducted a multicenter retrospective cohort study. Patients diagnosed with primary breast SCC who received adjuvant radiotherapy as part of their primary definitive treatment were included. Overall survival (OS), breast cancer-specific survival (BCSS), and recurrence-free interval (RFi) were evaluated.ResultsBetween January 2002 and December 2017, 25 breast SCC patients received adjuvant radiotherapy as a primary treatment were included. Median follow-up time was 43.5 months. Three (12%), fifteen (60%) and seven (28%) patients had clinical stage I, II and III disease, respectively. Fourteen patients underwent breast-conserving surgery and subsequent adjuvant radiotherapy. Eleven patients underwent mastectomy and post-mastectomy radiotherapy. Ten patients received regional lymph node irradiation. Nine (36%) patients had disease recurrence. The first site of recurrence was locoregional in five, but distant metastasis arose in one. Concurrent local and distant metastasis were seen in two. Six cases of local recurrence occurred within the irradiated site. Seven patients died, and six of the deaths were due to breast cancer. Five-year OS, BCSS, and Rfi were 69%, 70%, and 63%, respectively. In multivariate analysis, age and lymphatic invasion were associated with increased risk of recurrence.ConclusionBreast SCC has a high incidence of locoregional recurrence and poor prognosis. Age and lymphatic invasion are significant risk factors for recurrence.     

The international standard for interleukin-6 Evaluation in an international collaborative study

Three ampouled preparations of interleukin-6 (IL-6) were evaluated by 12 laboratories in seven countries for their suitability to serve as the international standard of IL-6. The preparations were assayed using in vitro bioassays and immunoassays. On the basis of the results reported here, with the agreement of the participants in the study and with the authorization of the Expert Committee on Biological Standardization (ECBS) of the World Health Organization (WHO) one of the preparations (coded 89/548) was established as the international standard of IL-6.     

Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN)

Background

Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations.

复杂性状遗传CC小鼠信息资源及研究应用

复杂性状遗传CC小鼠(CC小鼠)由不同遗传背景的小鼠品系杂交后,近交培育而成,用于研究人类复杂性状疾病和疾病的遗传差异。CC小鼠能体现不同小鼠亚种的遗传差异,其单核苷酸多态性是传统近交系小鼠的四倍。CC小鼠在生命科学与医学研究领域的应用越来越广泛。本文通过信息检索等方式对CC小鼠相关信息资源进行梳理,阐述了CC小鼠的起源、数据库、应用工具,以及研究领域等,以推动CC小鼠资源在中国得到广泛应用。     

Fall prevention intervention technologies: A conceptual framework and survey of the state of the art

In recent years, an ever increasing range of technology-based applications have been developed with the goal of assisting in the delivery of more effective and efficient fall prevention interventions. Whilst there have been a number of studies that have surveyed technologies for a particular sub-domain of fall prevention, there is no existing research which surveys the full spectrum of falls prevention interventions and characterises the range of technologies that have augmented this landscape. This study presents a conceptual framework and survey of the state of the art of technology-based fall prevention systems which is derived from a systematic template analysis of studies presented in contemporary research literature. The framework proposes four broad categories of fall prevention intervention system: Pre-fall prevention; Post-fall prevention; Fall injury prevention; Cross-fall prevention. Other categories include, Application type, Technology deployment platform, Information sources, Deployment environment, User interface type, and Collaborative function. After presenting the conceptual framework, a detailed survey of the state of the art is presented as a function of the proposed framework. A number of research challenges emerge as a result of surveying the research literature, which include a need for: new systems that focus on overcoming extrinsic falls risk factors; systems that support the environmental risk assessment process; systems that enable patients and practitioners to develop more collaborative relationships and engage in shared decision making during falls risk assessment and prevention activities. In response to these challenges, recommendations and future research directions are proposed to overcome each respective challenge.     

协同护理模式对乳腺癌根治术病人生存质量及化疗副反应的干预探讨

目的 通过本研究探讨针对乳腺癌根治术病人采取协同护理模式对其生存质量及化疗副反应的影响.方法 研究对象选取自本院2013年6月至2016年3月期间收治的乳腺癌根治术后化疗病人72例,按照数字分组法将人选对象分为干预组与对照组,每组36例;对照组病人给予常规护理,干预组病人在常规护理的基础上实施协同护理模式,对两组病人疼痛、毒副反应情况及生活质量评分进行比较.结果 对干预组与对照组病人分别实施协同护理模式和常规护理模式后,干预组的无痛率达到22.22％,而对照组中的无痛率仅为2.78％,干预组疼痛程度明显轻于对照组;毒副反应方面干预组患者的Ⅰ级、Ⅱ级毒副反应明显高于对照组,而在Ⅲ级、Ⅳ级毒副反应明显低于对照组;两组病人出院后SF-36评分比较,干预组明显高于对照组(P＜0.05).结论 对乳腺癌根治术病人实施协同护理模式有利于发挥病人及其家属的能动性作用,可使病人化疗期间副反应减少,并改善患者生活质量,在临床中有重要的价值.