羟基喜树碱联合化疗对中晚期非小细胞肺癌疗效观察

目的观察羟基喜树碱联合化疗中晚期非小细胞肺癌的疗效和毒副作用.方法 33例中晚期非小细胞肺癌患者联合应用羟基喜树碱、顺铂、环磷酰胺化疗,羟基喜树碱 10mg/d 3～ 7d,顺铂 40mg/ d 1～ 3d,环磷酰胺 800mg/ d 1d.结果总有效率为 51.5%.完全缓解 3例,部分缓解 14例;毒副作用主要为白细胞减少,血小板减少,恶心呕吐等,但多为轻中度反应.结论羟基喜树碱联合化疗中晚期非小细胞肺癌有效率高,毒副作用小,值得临床推广.     

思维导图在生物药物分析课程教学中的应用——以多糖类药物肝素的含量测定为例

生物药物的研究日新月异,与化学药物相比,其质量控制的方法有很多不同,对生物药物分析的教学提出新的要求。笔者针对该课程特点,以多糖类药物肝素的含量测定为例,进行了教学方法的探索和改进,尝试将思维导图应用于生物药物分析的课程教学,以达到提高课堂教学质量之目的。     

个性化护理对门诊皮试患儿依从性的影响

目的 探讨个性化护理对门诊患儿依从性的影响.方法 方便选取2016年8—10月福建医科大学附属宁德市医院儿科门诊行皮试的患儿120例作为研究对象,随机分为观察组和对照组各60例,对照组按常规的解释工作后进行皮试,观察组进行个性化护理干预,采用自拟问卷调查表进行护理质量满意度评价,采用描述性的研究方法,查阅资料了解儿童对不良刺激的反应及心理特点,比较两组满意度和依从性.结果 观察组皮试依从率76.0%,家长护理满意度95.0%,均高于对照组45.0%和88.3%,且比较差异有统计学意义(P<0.05).结论 个性化护理能使患儿在皮试过程中消除紧张恐惧的心理,增加自信心,提高患儿的依从性,提高患者服务满意度,减少护理纠纷发生.     

信息技术联合现场督导管理对手术室运行效率的影响

目的探讨信息技术联合现场督导管理提高手术室运行效率的效果。方法按时间段将2013年5~6月的首台手术597例、连台手术5 039例作为对照组,2015年5~6月的首台手术601例、连台手术5 512例作为观察组。对照组按常规实施管理,即应用常规手麻信息系统,手术医生、护士按常规实施手术;观察组在原信息系统中融入患者入手术间、麻醉开始、手术开始等6项关键时间节点,设查询专栏;建立健全相关制度,现场督导落实到位。结果观察组首台手术准点率显著高于对照组,连台手术等待时间及手术时间显著短于对照组;2015年手术间手术量显著高于2013年(均P0.01)。结论信息技术联合现场督导管理,可有效提高首台手术准时开始率及缩短连台手术等待时间,提高手术室运行效率。     

产前标式强化护理干预在预防高龄产妇产后出血中的应用

目的：探讨产前标式强化护理干预在预防高龄产妇产后出血中的应用效果。方法：将2018年6月1日～2019年6月30日入院的73例高龄产妇作为对照组,采用常规产前护理干预;将2019年7月1日～2020年6月30日入院的67例高龄产妇作为研究组,采用产前标式强化护理干预。比较两组分娩各产程时间、分娩结局、干预前后自我效能[采用简化版分娩自我效能量表(CBSEI-C32)]、心理状态[采用状态-特质焦虑问卷(STAI)]。结果：研究组第一产程、第二产程时间均短于对照组(P<0.05);研究组剖宫产、产后出血、新生儿窒息发生率均低于对照组(P<0.05);干预后1 d,研究组CBSEI-C32评分高于干预前(P<0.05),且高于同期对照组(P<0.05);干预后1 d,研究组状态焦虑量表(S-AI)、特质焦虑量表(T-AI)评分均低于干预前(P<0.05),且低于同期对照组(P<0.05)。结论：产前标式强化护理干预有助于缩短产妇分娩产程,调节产妇分娩自我效能与心理状态,改善产妇分娩结局。     

新型冠状病毒肺炎疫情期发热门诊咽拭子标本采样管理

总结新型冠状病毒肺炎疫情期间发热门诊咽拭子的风险防控措施。重点是优化咽拭子采样区的布局和流程,实施不同人群的分类分时段采样,强化采样人员的岗前培训和考核,关注采样人员心理健康,制定采样期间标准操作流程和采样后实施全面的人、环境和物品集束化处理。发热门诊共采集咽试子样本12 933例次,采样区护理人员未发生新型冠状病毒感染。     

1018例甲状腺癌临床病理分析

Objective To explore the incidence and pathologic feature of patients with thyroid carcinoma treated at the First Hospital of Jilin University. Methods From January 2000 to July 2010,clinicopathologic data of 1018 patients with thyroid carcinoma treated in the First Hospital of Jilin University were retrospectively analyzed. Results The cases of thyroid carcinoma between 2008 and 2010 were more than 73% higher than that in the preceding 8 years. Cancer cases from January 2009 to July 2010 were more1018 cases reviewed, 976 cases were clearly classified pathologically. Papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma and anaplastic thyroid carcinoma were present in 897 (91.91%), 43(4. 41% ), 22(2. 25% ) and 6(0. 61% ) cases respectively. Of the 1018 cases reviewed,804 cases were recorded with or without lymphnode metastasis. The rate of lymphnode metastasis of male and female patient were 39. 24% and 28. 64% respectively and the difference was significant( χ2 = 6. 71 ,P ＜0. 05). The rate of lymphnode metastasis of age ＜45 years and age ≥45 years were 37.65% and 23. 26%respectively and the difference was significant ( χ2 = 19. 54, P ＜ 0. 05 ). Conclusions In the past ten and a half years, the number of the thyroid carcinoma patients treated in the First Hospital of Jilin University increased year by year. The increase of papillary thyroid carcinoma was the most obvious. Thyroid carcinoma was more common among females. The peak incidence age of males and females was 30 -59. The rate of lymphnode metastasis of males was larger than that of females. The rate of lymphnode metastasis of age ＜45years was larger than that of age≥45 years.     

1018例甲状腺癌临床病理分析

目的 探讨吉林大学第一医院甲状腺外科收治患者中甲状腺癌的发病状况及病理学特征.方法 回顾性分析吉林大学第一医院2000年1月-2010年7月收治的1018例甲状腺癌患者的临床病理资料.结果 2008年、2009年收治的甲状腺癌患者比之前8年总数高73%以上,2009年1月至2010年7月一年半收治的甲状腺癌患者比之前9年的总数高48%以上;男女发病比例约为1∶4.0;1018例甲状腺癌患者中病理类型明确者976例,其中乳头状癌897例(91.91%),滤泡状癌43例(4.41%),髓样癌22例(2.25%),未分化癌6例(0.61%);1018例甲状腺癌患者中淋巴结转移情况明确者804例,男、女淋巴结转移率分别为39.24%、28.64%,二者差异有统计学意义(χ2=6.71,P＜0.05),45岁以下(不包括45岁)及45岁以上患者淋巴结转移率分别为37.65%、23.26%,二者差异有统计学意义(χ2=19.54,P＜0.05).结论 过去的10年半我院收治的甲状腺癌患者逐年增多,以乳头状癌患者升高最明显,女性患者数明显多于男性,男女发病年龄高峰均为30～59岁.淋巴结转移率男性大于女性,45岁以下患者多于45岁以上患者.

Abstract：

Objective To explore the incidence and pathologic feature of patients with thyroid carcinoma treated at the First Hospital of Jilin University. Methods From January 2000 to July 2010,clinicopathologic data of 1018 patients with thyroid carcinoma treated in the First Hospital of Jilin University were retrospectively analyzed. Results The cases of thyroid carcinoma between 2008 and 2010 were more than 73% higher than that in the preceding 8 years. Cancer cases from January 2009 to July 2010 were more1018 cases reviewed, 976 cases were clearly classified pathologically. Papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma and anaplastic thyroid carcinoma were present in 897 (91.91%), 43(4. 41% ), 22(2. 25% ) and 6(0. 61% ) cases respectively. Of the 1018 cases reviewed,804 cases were recorded with or without lymphnode metastasis. The rate of lymphnode metastasis of male and female patient were 39. 24% and 28. 64% respectively and the difference was significant( χ2 = 6. 71 ,P ＜0. 05). The rate of lymphnode metastasis of age ＜45 years and age ≥45 years were 37.65% and 23. 26%respectively and the difference was significant ( χ2 = 19. 54, P ＜ 0. 05 ). Conclusions In the past ten and a half years, the number of the thyroid carcinoma patients treated in the First Hospital of Jilin University increased year by year. The increase of papillary thyroid carcinoma was the most obvious. Thyroid carcinoma was more common among females. The peak incidence age of males and females was 30 -59. The rate of lymphnode metastasis of males was larger than that of females. The rate of lymphnode metastasis of age ＜45years was larger than that of age≥45 years.     

HPLC测定两种不同浓度乙醇提取补骨脂素的含量

目的：建立高效液相色谱测定用50%和75%两种不同浓度乙醇分别从补骨脂中提取、分离补骨脂素含量的方法。方法：高效液相色谱法。C18色谱柱（4.6mm×250mm,5μm）;流动相：甲醇-1%冰醋酸（50：50）;流速：1.0mL/min;λ：245nm。结果：两种不同浓度的补骨脂素提取物均在进样量22.0～440.0ng内线性关系良好;r=0.9993。结论：HPLC方法操作简便,重现性较好,结果准确。从含量测定方面进比较,认为在生产中用50%乙醇从补骨脂中提取补骨脂素优于用75%乙醇浓度。