花卷茶提取物对高胆固醇血症大鼠血脂和内皮功能的影响

目的研究花卷茶提取物对高胆固醇血症大鼠血脂和内皮功能的影响及机制。方法雄性SD大鼠高脂饲养4周诱发高胆固醇血症,其中实验组在高脂饲料饲养2周后开始每日灌胃给予不同剂量的花卷茶系列之十两茶水提物（50、100和200mg.kg-1）,持续2周。实验结束后,颈动脉取血测定血脂、一氧化氮（NO）、非对称二甲基精氨酸（ADMA）和丙二醛（MDA）含量;分离胸主动脉检测血管内皮依赖性舒张功能。结果十两茶提取物能呈剂量依赖性降低高脂血症大鼠血清总胆固醇和低密度脂蛋白及甘油三酯水平。十两茶提取物能显著改善高脂所诱导的血管内皮舒张功能障碍,降低血浆ADMA和MDA含量以及增加NO水平,且呈剂量依赖性。结论花卷茶系列之十两茶提取物具有降低血脂和保护血管内皮功能作用,其作用与抑制脂质过氧化、调节ADMA/NO系统有关。     

归脾汤治疗妇科病举隅

归脾汤是严用和治疗失眠证的方剂，由白术、茯苓、黄芪、党参、龙眼肉、酸枣仁、木香、炙甘草八味组成。有补益心脾、养心安神之功，主治思虑过度，劳伤心脾，健忘怔忡。现将笔者运用此方加减治疗几种妇科病，举隅如下。     

阿尔茨海默病患者精神行为与异生皮质血流水平的关系

目的 探讨不同程度阿尔茨海默病(AD)患者大脑异生皮质区CT血流灌注水平及其与精神行为的相关性.方法 随机选择60例AD患者及30例健康老人,进行简易智能状态量表(MMSE)检查,并选取海马区层面进行CT血流灌注扫描,获得感兴趣区的血流灌注值.另用临床痴呆量表将AD组分为轻、中、重度3组,并通过阿尔茨海默病行为病理评定量表(BEHAVE-AD)检查.结果 AD患者行为紊乱最为多见,其次为妄想,发生率分别为81.7%及58.3%.重度组行为紊乱程度明显高于中、轻度组.中度组妄想分明显高于轻度组(P＜0.05).AD组与健康组的双侧海马结构、内嗅区及右前下托的达峰时间(TTP)比较差异均有显著统计学意义(P＜0.01).中度组TTP分别为(21.70±7.95)s,(21.46±7.40)s,(21.62±7.25)s,(21.15±6.83)s,(21.26±7.25)s,较轻度组、健康组明显延长(P＜0.05).相关分析显示异生皮质TTP与行为紊乱、妄想呈正相关(P＜0.05),与情感障碍呈负相关(P＜0.05).结论 AD患者出现行为紊乱、妄想以及情感障碍与大脑异生皮质区慢性缺血导致神经传导障碍有一定关系.

Abstract：

Objective To explore the relationship between behavioral psychological symptoms in Alzheimer' s dementia(AD) patients and region-specific alterations in cerebral blood flow. Methods 60 patients with AD randomly selected from a psychiatric outpatient department and 30 randomly selected healthy elderly community controls were administered the Mini-Mental State Exam (MMSE). All subjects underwent a perfusion CT scan to assess blood perfusion in brain regions of interest. The AD subjects were administered the behavioral patholigy in alzheimer' s disease(BEHAVE-AD) Rating Scale classified as mild, moderate or severe based on the results of the Clinical Dementia Rating scale. Results The most incidence was conduct disorder and the next was delusion.The score was 81.7% and 58.3% in turn. The conduct disorder score was higher in the severe demented group than in the mildly and moderate demented group(P＜0. 05). The delusion score was higher in the moderate demented group than that in the mildly demented group(P＜0.05). The time to peak(TTP)scores in the four groups of subjects were significantly different in the bilateral hippocampal formation, anteroinferior subiculum and entorhinal area. The TTP score was significantly higher in the moderately demented group than that in the mildly demented group and the control group(P＜0. 05 ). Correlation analysis identified a positive correlation between conduct disorder, delusions and TTP in cerebral heteroplasia cortex (P ＜ 0. 05 ), also identified a negative correlation between mood disorder and TTP(P＜0. 05 ). Conclusion The conduct disorder,delusions and mood disorder in AD are associated with the chronicity ischemia of cerebral heteroplasia cortex leading to neural conduction disorders.     

中枢性高热患者冰毯与冰帽合用的护理体会

本院自2006年开始对颅脑损伤和重症脑血管疾病高热患者使用冰毯与冰帽合用降温,控制中枢性高热,取得了满意效果,现将护理体会报告如下.     

中枢性高热患者冰毯与冰帽合用的护理体会

本院自2006年开始对颅脑损伤和重症脑血管疾病高热患者使用冰毯与冰帽合用降温,控制中枢性高热,取得了满意效果,现将护理体会报告如下。1临床资料 颅脑外伤患者78例,男42例,女36例,平均53岁;高血压脑出血10例,男4例,女6例,平均68岁;体温39-42℃,冰毯与冰帽合用3-45d,平均23d。     

情景模拟教学法联合Mini-CEX在内科住院医师培训中的应用

目的：探讨情景模拟教学法联合Mini-CEX在内科住院医师培训中的应用效果。方法：采用随机数字表法将本院66名内科住院医师分为对照组与试验组，每组各33名，对照组采用传统培训方法，试验组采用情景模拟教学法联合Mini-CEX。两组住院医师均于培训前、培训3个月及6个月后分别进行理论考核与临床技能操作考核，并比较两组对培训的满意程度。结果：培训前两组理论考核、临床技能操作考核评分差异无统计学意义(P>0.05),培训3个月及6个月后试验组理论考核、临床技能操作考核评分均高于对照组(P<0.05);培训6个月后试验组对培训的满意度高于对照组(P<0.05)。结论：情景模拟教学法联合Mini-CEX在内科住院医师培训中应用能够明显提升教学效果，且住院医师对该教学模式的满意度较高。