表皮生长因子与慢性萎缩性胃炎研究进展

表皮生长因子(EGF)是最早被发现的多肽类生长因子之一，它能提高葡萄糖和氨基酸的吸收，刺激蛋白质DNA和RNA的合成。近年来的研究发现，表皮生长因子家族与胃粘膜疾病关系密切。此文综述EGF的结构和生物学活性，及其在萎缩性胃炎发生发展和治疗中的作用。     

药物治疗胃溃疡疗效初探

慢性胃溃疡(Cu)属胃癌癌前病变,迁延不愈,反复发作的Cu癌变率高。为防止Cu的癌变,必须快速有效的治愈Cu。由于Cu发病机理迄今尚未明了,临床上治疗方法及药物繁多,疗效报告不一,我们选择了目前常用且一般认为有效的药物,对205例慢性胃溃疡患者分组对比治疗,以寻求高效、低毒、经济、方便的治疗慢性胃溃疡的方法。     

颌面部放线菌病2例报告

放线菌病发生于颌面部者较为少见,临床上鉴别诊断较困难,现将2例报告如下。例1,男,54岁。该患于2个月前发现左颌下区肿物,无痛、肤色无著变。6龋坏,经牙体及抗炎治疗后,左颌下肿物未见好转。且肤     

天疱疮和类天疱疮患者生活质量评定及影响因素分析

目的评价天疱疮和类天疱患者的生活质量,探讨影响其生活质量的相关因素。方法选择本科门诊84例大疱病患者(天疱疮44例,类天疱疮40例),并以银屑病患者作为对照组,采用世界卫生组织生活质量测定量表简表(WHOQOL-BREF)、皮肤病生活质量指数(DLQI)及简明健康调查问卷(SF-36)对寻常性银屑病、天疱疮和类天疱疮三组患者的生活质量进行评定,并对影响其生活质量的相关因素进行分析。结果天疱疮组和类天疱疮组WHOQOL-BREF总体感受得分低于银屑病组,差异有统计学意义(P0.05);天疱疮组和类天疱疮组与银屑病组DLQI总分比较,差异无统计学意义(P0.05);类天疱疮组在生理机能领域的得分低于天疱疮组,天疱疮和类天疱疮患者中皮损累及皮肤黏膜者在社会功能领域的得分低于累及皮肤者,疾病重度者在生理职能和情感职能领域的得分低于轻、中度者,有合并症者在生理机能和情感职能领域的得分低于无合并症者,差异均有统计学意义(P均0.05)。结论天疱疮和类天疱疮患者较银屑病患者生活质量低,疾病类型、皮损分布、疾病严重度和有无合并(并发)症对两种大疱病患者的生活质量有明显的影响。     

不同修饰剂对水热法制备羟基磷灰石粒径大小的影响

背景:不同粒径与形貌的纳米羟基磷灰石具有不同的表面特性与生物活性,通过对羟基磷灰石表面进行改性,进而合成出不同粒径的纳米羟基磷灰石,可扩大纳米羟基磷灰石的应用领域.目的:分析了水热合成法制备羟基磷灰石过程中,实验条件如修饰剂种类、pH 值等对羟基磷灰石粒径的影响.方法:以磷酸与硝酸钙为原料,D-山梨醇、聚丙烯酸钠以及吐温80 作为有机修饰剂,不同pH 值条件下,水热合成不同粒径的羟基磷灰石.结果与结论:无修饰剂时,羟基磷灰石的粒径随pH 增加迅速降低.聚丙烯酸钠的存在有利于小粒径羟基磷灰石的生成;D-山梨醇的存在有利于较大粒径羟基磷灰石的生成;吐温80 的加入在一定程度上降低了羟基磷灰石粒径.     

书面沟通与互动在提升新护士职业稳定性中的作用

目的 探索应用书面沟通与互动提高新护士职业稳定性的方法,评价实施效果.方法 通过书面沟通,与指导老师交流,召开座谈会的干预措施,对17名新护士在实施干预前后进行调查.结果 书面沟通与互动帮助护理管理者及时了解新护士的思想动态与需求,实施个性化干预,促进新护士思维能力和专业水平的提高.结论 书面沟通与互动是提高新护士职业稳定性行之有效的方法之一.     

匹维溴铵联合双歧杆菌三联活菌和多塞平治疗腹泻型肠易激综合征的疗效分析

目的 选用胃肠动力调节剂、肠道微生态制剂以及三环类抗抑郁药,针对肠易激综合征(IBS)可能的病因干预治疗,观察单药、双药及三药治疗对IBS的影响,从治疗学的角度来验证可能存在的交互发病因素.方法 选择腹泻型IBS(D-IBS)患者103例,均符合罗马Ⅱ诊断标准,均经电子肠镜检查排除肠道器质性疾病,并能按规定要求完成随访.将103例患者按随机数字表法分为四组:单用匹维溴铵组26例,匹维溴铵+双歧杆菌三联活菌组28例,匹维溴铵+多塞平组25例,匹维溴铵+双歧杆菌三联活菌+多塞平组24例.用药前、用药后4周分别进行IBS症状评分、肠道菌群培养、SCL-90精神评分.结果 匹维溴铵+双歧杆菌三联活菌+多塞平组总有效率[83.33%(20/24)]显著高于单用匹维溴铵组[65.38%(17/26)]、匹维溴铵+双歧杆菌三联活菌组[71.43%(20/28)]、匹维溴铵+多寒平组[68.00%(17/25)],差异有统计学意义(P<0.05).四组用药后对五种肠道益生菌及精神症状都有明显影响,联合干预更为显著.结论 针对IBS发病相关因素进行不同干预可有效治疗IBS患者,IBS发病因素互为影响,从治疗角度支持脑.肠互动在IBS发病中的重要作用.

Abstract：

Objective To evaluate the efficacy of stomach intestine power regulator, intestinal microecology preparation and tricyclic antidepressant treatment in irritable bowel syndrome (IBS), and to investigate its pathological mechanism. Methods From November 2006 to November 2010, 103 patients with diarrhea-dominant IBS (D-IBS), who fulfilled the Rome Ⅱ criteria and were excluded from organic disease by entewscope were divided into pinaverium bromide group (26 cases), pinaverium bromide + bifid triple viable group (28 cases), pinaverium bromide + doxepin group (25 cases) and pinaverium bromide +bifid triple viable + doxepin group(24 cases ) by random digits table. The symptom grade, intestinal flora and SCL-90 was tested before treatment and 4 weeks after treatment. Results The total effective rate of pinaverium bromide + bifid triple viable + doxepin group was 83.33%(20/24), significant higher than that in pinaverium bromide group [65.38%(17/26)], pinaverium bromide + bifid triple viable group [71.43%(20/28)], pinaverium bromide + doxepin group [68.00% ( 17/25 )] (P < 0.05 ). Five kinds of intestinal flora and psychiatric symptoms were improved in the four groups, and those in pinaverium bromide + bifid triple viable + doxepin group improved significantly. Conclusions To interfere the correlation factor of IBS can have better efficacy. There is a close relation between brain and gut in patients with IBS, which may be involved in the pathogenesis of IBS.     

第155例腹部刀刺伤-腹部搏动性包块-发热-消化道出血

病例摘要 患者女,33岁,因"发现腹部包块4个月",于2007年3月1日人院.约4个月前,患者体检时发现"腹部肿块",无明显腰痛、腹痛、腹胀,无发热,无头晕、胸闷、心悸、气急,无恶心呕吐、腹泻,无尿频、尿急、尿痛、肉眼血尿,就诊当地医院,B超提示"腹主动脉假性动脉瘤,慢性胆囊炎",未予特殊处理.     

Effect of mica monomer powder on chief and parietal cells as well as G and D cells in gastric mucosa of chronic atrophic gastritis in rats

Objective:To study the regulative action of mica monomer powder preparation on the chief and parietal cells as well as G and D cells in the gastric mucosa of the experimental atrophic gastritis(CAG)rats.Methods:Intervention therapy was given to the experimental CAG rats at three different doses of mica monomer powder preparation to evaluate the changes of chief and parietal cells as well as G and D cells in the gastric mucosa and the histopathological changes of gastric mucosa.Results:Mica monomer powder preparation at three different doses could increase the amount of chief and parietal cells as well as G and D cells in gastric mucosa of the experimental CAG rats and alleviate and control the inflammation of gastric mucosa and the atrophy of gastric mucosa glands.Especially,better effects were shown in the mid and high dose groups.Conclusion:Mica has the pharmacological action of protecting the gastric mucosa,promoting the regeneration of gastric glands,enhancing blood flow of the gastric mucosa,and consequently improving the inflammatory responses of the gastric mucosa.One of the mechanisms is associated with promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism including gut hormone secretion(gastrin and somatostatin)by increasing the number of chief and parietal cells as well as G and D cells.     

Toll样受体与炎症性肠病关系探讨

Toll样受体家族是一种识别微生物体上保守结构——病原体相关的分子结构的模式识别受体。它可以表达于肠道粘膜的多种细胞中,介导微生物与细胞之间的相互作用,在粘膜免疫中发挥重要作用。近年来的研究显示,炎症性肠病与肠道免疫异常和粘膜稳态破坏相关,而Toll样受体在其中具有重要的作用。