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41.
Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults 总被引:3,自引:0,他引:3
Nitayaphan S Pitisuttithum P Karnasuta C Eamsila C de Souza M Morgan P Polonis V Benenson M VanCott T Ratto-Kim S Kim J Thapinta D Garner R Bussaratid V Singharaj P el-Habib R Gurunathan S Heyward W Birx D McNeil J Brown AE;Thai AIDS Vaccine Evaluation Group 《The Journal of infectious diseases》2004,190(4):702-706
ALVAC-HIV (vCP1521) and AIDSVAX B/E were evaluated in a phase 1/2 trial of human immunodeficiency virus (HIV)-negative Thai adults. Of 133 volunteers enrolled, 122 completed the trial. There were no serious vaccine-related adverse events, nor were there intercurrent HIV infections. Lymphoproliferative responses to glycoprotein 120 E were induced in 63% of the volunteers, and HIV-specific CD8 cytotoxic T lymphocyte responses were induced in 24%. Antibody responses increased in frequency and magnitude in association with the dose level of AIDSVAX B/E. Binding and neutralizing antibodies to the MN strain were induced in 100% and 98%, respectively, of the volunteers receiving 600 microg of AIDSVAX B/E, and such antibodies to E strains were induced in 96% and 71%, respectively, of these volunteers. This vaccine combination was well tolerated and was immunogenic, meeting milestones for advancement to phase 3 evaluation. 相似文献
42.
Douching and endometritis: results from the PID evaluation and clinical health (PEACH) study 总被引:8,自引:0,他引:8
Ness RB Soper DE Holley RL Peipert J Randall H Sweet RL Sondheimer SJ Hendrix SL Hillier SL Amortegui A Trucco G Bass DC;PID Evaluation Clinical Health 《Sexually transmitted diseases》2001,28(4):240-245
BACKGROUND: Douching has been related to risk of pelvic inflammatory disease (PID). GOAL: To examine the association between douching and PID in a large, multicenter, clinical trial of PID after adjustment for race/ethnicity. STUDY DESIGN: Interviews were conducted with 654 women who had signs and symptoms of PID. Vaginal Gram stains and upper genital tract pathology/cultures were obtained from all the women. Women with evidence of plasma cell endometritis and/or gonococcal or chlamydial upper genital tract infections were compared with women who had neither endometritis nor upper genital tract infection. RESULTS: Women with endometritis or upper genital tract infection were more likely to have douched more than once a month or within 6 days of enrollment than women who never douched. These associations remained after adjustment for confounding factors, after analysis of black women only; and among women with normal or intermediate vaginal flora but not bacterial vaginosis. CONCLUSION: Among a predominantly black group of women with clinical PID, frequent and recent douching was associated with endometritis and upper genital tract infection. 相似文献
43.
One stop shop versus collaborative integration: what is the best way of delivering sexual health services? 下载免费PDF全文
French RS Coope CM Graham A Gerressu M Salisbury C Stephenson JM;One-Stop Shop Evaluation Team 《Sexually transmitted infections》2006,82(3):202-206
OBJECTIVES: To examine various models of integrated and/or one stop shop (OSS) sexual health services (including general practice, mainstream specialist services, and designated young people's services) and explore their relative strengths and weaknesses. METHODS: Literature review and interviews with key informants involved in developing the National Strategy for Sexual Health and HIV (n = 11). RESULTS: The paper focuses on five broad perspectives (logistics, public health, users, staff, and cost). Contraceptive and genitourinary medicine issues are closely related. However, there is no agreement about what is meant by having "integrated" services, about which services should be integrated, or where integration should happen. There are concerns that OSSs will result in over-centralisation, to the disadvantage of stand alone and satellite services. OSS models are potentially more user focused, but the stigma that surrounds sexual health services may create an access barrier. From staff perspectives, the advantages are greater career opportunities and increased responsibility, while the disadvantages are concern that OSSs will result in loss of expertise and professional status. Cost effectiveness data are contradictory. CONCLUSION: Although there is a policy commitment to look at how integrated services can be better developed, more evidence is required on the impact and appropriateness of this approach. 相似文献
44.
军队医学科研项目评价指标体系的构建 总被引:7,自引:0,他引:7
本研究以评价理论为指导,在调研相关资料的基础上,运用系统理论、专家咨询、层次分析、统计分析等理论方法,研究并建立了一套适合我军医学科研工作特点及需要的科研课题评价指标体系.该体系量化可比、具有较强的适用性、导向性及操作性. 相似文献
45.
临床两组药物等效的判断方法及其辨析 总被引:11,自引:1,他引:10
临床两组药效比较 ,最严谨的方法是等效性检验。而用把握度进行例数估算 ,若出现P >0 .0 5 ,则难下结论 ,既不表示按估算的例数进行试验 ,就可做出两组药效基本相同的结论 ,也不能认为只要例数足够多 ,P >0 .0 5也能说明两组基本等效。一般t检验不宜作“两组药效基本相同”的分析 相似文献
46.
Malone FD Canick JA Ball RH Nyberg DA Comstock CH Bukowski R Berkowitz RL Gross SJ Dugoff L Craigo SD Timor-Tritsch IE Carr SR Wolfe HM Dukes K Bianchi DW Rudnicka AR Hackshaw AK Lambert-Messerlian G Wald NJ D'Alton ME;First- Second-Trimester Evaluation of Risk 《The New England journal of medicine》2005,353(19):2001-2011
47.
48.
Efficacy and safety of recombinant human activated protein C for severe sepsis 总被引:168,自引:0,他引:168
Bernard GR Vincent JL Laterre PF LaRosa SP Dhainaut JF Lopez-Rodriguez A Steingrub JS Garber GE Helterbrand JD Ely EW Fisher CJ;Recombinant human protein C Worldwide Evaluation in Severe Sepsis 《The New England journal of medicine》2001,344(10):699-709
BACKGROUND: Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin alfa activated produced dose-dependent reductions in the levels of markers of coagulation and inflammation in patients with severe sepsis. In this phase 3 trial, we assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis. METHODS: We conducted a randomized, double-blind, placebo-controlled, multicenter trial. Patients with systemic inflammation and organ failure due to acute infection were enrolled and assigned to receive an intravenous infusion of either placebo or drotrecogin alfa activated (24 microg per kilogram of body weight per hour) for a total duration of 96 hours. The prospectively defined primary end point was death from any cause and was assessed 28 days after the start of the infusion. Patients were monitored for adverse events; changes in vital signs, laboratory variables, and the results of microbiologic cultures; and the development of neutralizing antibodies against activated protein C. RESULTS: A total of 1690 randomized patients were treated (840 in the placebo group and 850 in the drotrecogin alfa activated group). The mortality rate was 30.8 percent in the placebo group and 24.7 percent in the drotrecogin alfa activated group. On the basis of the prospectively defined primary analysis, treatment with drotrecogin alfa activated was associated with a reduction in the relative risk of death of 19.4 percent (95 percent confidence interval, 6.6 to 30.5) and an absolute reduction in the risk of death of 6.1 percent (P=0.005). The incidence of serious bleeding was higher in the drotrecogin alfa activated group than in the placebo group (3.5 percent vs. 2.0 percent, P=0.06). CONCLUSIONS: Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding. 相似文献
49.
Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan 下载免费PDF全文
Tetsuya Mizoue Norie Sawada Ayaka Kotemori Keitaro Matsuo Isao Oze Hidemi Ito Mariko Naito Tomio Nakayama Yuri Kitamura Akiko Tamakoshi Ichiro Tsuji Yumi Sugawara Manami Inoue Chisato Nagata Atsuko Sadakane Keitaro Tanaka Shoichiro Tsugane Taichi Shimazu for the Research Group for the Development Evaluation of Cancer Prevention Strategies in Japan 《International journal of cancer. Journal international du cancer》2018,143(2):307-316
Coffee is a rich source of bioactive compounds that have potential anticarcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,274 person‐years, 6,711 incident colorectal cancer cases were identified. Study‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using the random effects model. Coffee drinking was not materially associated with colorectal cancer risk in men or women (pooled HR 0.92, 95% CI 0.82–1.03 in men and pooled HR 0.90, 95% CI 0.76–1.07 in women). Analysis by subsite showed a lower risk of colon cancer among female drinkers of ≥3 cups coffee/day (pooled HR 0.80, 95% CI 0.64–0.99). There was no such association in men. Coffee drinking was not associated with risk of rectal cancer in men or women. Results were virtually the same among never smokers except for an increased risk of rectal cancer associated with frequent coffee consumption. Coffee drinking may be associated with lower risk of colon cancer in Japanese women. 相似文献
50.