盐酸噻氯匹定胶囊的相对生物利用度

研究国产盐酸噻氯匹定和进口片的药物动力学和相对生物利用度。方法：采用ＨＰＬＣ法测定１０例健康志愿者ｐｏ５００ｍｇＡ和Ｂ后，盐酸噻氯匹定在血浆中的浓度，计算两者的药物动力学参数和相对生物利用度，并进行统计学分析 。     

腮腺腺淋巴瘤超微结构分析

腺淋巴瘤(乳头状淋巴囊腺癌)的组织发生问题意见尚未一致。本文报告一例腮腺腺淋巴瘤的光镜和电镜检查结果,探讨该肿瘤的组织来源。患者男性,60岁。左耳后蚕豆大肿物发现二年,生长不明显,无任何自觉症状。口腔颌面部检查:左耳后下部表面皮肤正常,肿物约3.2×3.0×2.5cm,边界清楚,表面光滑,质地柔韧,固定、无压痛。口内腮腺导管口及唾液分泌未见异常。颌下未扪及肿大淋巴     

五黄液对慢性鼻-鼻窦炎鼻内镜术后患者鼻黏膜纤毛功能的影响

目的:观察五黄液鼻腔灌洗对慢性鼻-鼻窦炎鼻内镜术后患者鼻黏膜纤毛功能的影响。方法:将40例慢性鼻-鼻窦炎经鼻内镜术后患者随机分为治疗组和对照组,每组各20例。治疗组采用五黄液灌洗鼻腔治疗,对照组采用0. 9%氯化钠注射液灌洗鼻腔治疗。观察2组术前及术后1、3、6个月鼻黏膜纤毛传输速率的变化情况。结果:术前及术后6个月,2组鼻黏膜纤毛传输速率差异无统计学意义(P 0. 05);术后1、3个月,治疗组鼻黏膜纤毛传输速率较对照组更快,差异有统计学意义(P 0. 05)。结论:五黄液在促进慢性鼻-鼻窦炎鼻内镜术后患者早期鼻黏膜纤毛功能恢复方面有较好疗效。     

胆囊穿刺置管造口引流术对老年急性化脓坏疽性胆囊炎患者的临床疗效及安全性

目的探讨穿刺置管造口引流术对老年急性化脓坏疽性胆囊炎患者的临床疗效及安全性。方法选取2011年10月至2016年12月在本院治疗的46例老年急性化脓坏疽性胆囊炎患者进行回顾性分析,其中23例患者采用腹腔镜下胆囊切除术进行治疗,作为对照组;另外23例患者采用胆囊穿刺置管造口引流术结合腹腔镜下胆囊切除术进行治疗,作为试验组。随访6个月,观察两组患者的治疗情况及并发症发生情况。结果试验组患者手术时间、术中出血量、休克纠正时间、体温恢复时间、白细胞恢复时间及凝血功能恢复时间等明显低于对照组,具有统计学意义(P0.05);试验组患者发生胆管损伤、腹腔内出血、胆汁漏、皮下气肿等并发症发生率(4.3%)明显低于对照组(26.10%),具有统计学意义(P0.05);术后3个月经超声复查两组患者均未发生胆管狭窄、残余胆囊等情况。结论胆囊穿刺置管造口引流术联合腹腔镜胆囊切除术用于老年急性化脓坏疽性胆囊炎患者的治疗能够有效的减少并发症,具有良好的临床效果和安全性。     

异种骨作为骨组织工程支架材料的免疫学及相关研究进展

骨组织工程的出现为临床治疗骨缺损提供了新的选择,而寻找理想的支架材料是目前骨组织工程研究的热点.本文围绕作为组织工程骨支架材料之一的异种骨的免疫学及相关研究进展作一综述.     

湖北省部分地区农民工生活质量及相关影响因素调查

Objective The aim of the study was to understand the quality of life and the related factors of farmer workers in the countryside of Hubei province. Methods Purposive sampling was used to select 529 farmer workers and another 326 government workers were served as controls.'Group investigation' method was used in this study, t-test was used to compare the quality of life among farmer workers and the Chinese norm. SF-36 was used to measure the quality of life. Generalized linear regression model(GLM)and structural equation model(SEM)were applied to test the related factors. Results Quality of life among farmer workers in Hubei was significantly different from the norm of residents in Hangzhou. The quality of life among migrant workers was significantly lower than the government staff(PRP＜0.05, PBP＜0.05, PVT＜0.05)after controlling the confounding factors. Factors as age(B=-0.33), sex(B=-0.07), marital status(B=-0.10),sleeping habits(B=-0.16), fatigue(B=-0.12), life style(B=-0.05)and social status(B=0.93)etc. were related to the quality of life. Conclusion The quality of life among farmer workers was poor, and mainly affected by age, sex, marital status, sleeping habits, fatigue, lifestyle and social status. It is important to reduce the work load and making the work status and life style reasonable to better the quality of life among the farmer workers.     

湖北省部分地区农民工生活质量及相关影响因素调查

Objective The aim of the study was to understand the quality of life and the related factors of farmer workers in the countryside of Hubei province. Methods Purposive sampling was used to select 529 farmer workers and another 326 government workers were served as controls.'Group investigation' method was used in this study, t-test was used to compare the quality of life among farmer workers and the Chinese norm. SF-36 was used to measure the quality of life. Generalized linear regression model(GLM)and structural equation model(SEM)were applied to test the related factors. Results Quality of life among farmer workers in Hubei was significantly different from the norm of residents in Hangzhou. The quality of life among migrant workers was significantly lower than the government staff(PRP＜0.05, PBP＜0.05, PVT＜0.05)after controlling the confounding factors. Factors as age(B=-0.33), sex(B=-0.07), marital status(B=-0.10),sleeping habits(B=-0.16), fatigue(B=-0.12), life style(B=-0.05)and social status(B=0.93)etc. were related to the quality of life. Conclusion The quality of life among farmer workers was poor, and mainly affected by age, sex, marital status, sleeping habits, fatigue, lifestyle and social status. It is important to reduce the work load and making the work status and life style reasonable to better the quality of life among the farmer workers.     

基于"脾应长夏恶湿"理论探讨长夏季节湿疹高发的生物学机制

湿疹高发于长夏湿热环境中,其具体生物学机制尚未明确.联系环境变化对人的影响,从季节温湿变化阐释"脾应长夏"的理论,并根据现有科学成果提出支持本观点的物质基础与科学内涵,即"脾应长夏,喜燥恶湿"与褪黑素调控NF-κB介导的Th1/Th2免疫平衡之间具有密切联系,这是影响长夏季节湿疹高发的关键因素.本文从分析季节气候变化对人体生理病理产生重要影响、长夏季易发外内合邪与免疫相关的湿邪疾病、长夏季节湿疹高发的重要机制等多方面展开探讨,揭示长夏季节湿疹高发的生物学机制.提出"脾应长夏恶湿"理论与松果腺-褪黑素引起皮肤NF-κB-Th1/Th2调节链的季节性变化具有相关性:导致湿疹长夏季节高发的外界影响因子主要是温湿度季节性变化,中介物质是褪黑素,调节机制是皮肤中NF-κB介导的Th1/Th2细胞因子分泌的季节性变化.     

成人先天性巨结肠48例临床诊治体会

探讨成人先天性巨结肠的诊断及治疗方法的选择。回顾性分析近5年收治的48例成人先天性巨结肠患者的临床资料。手术治疗组疗效明显优于非手术治疗组,手术治疗组采用Soave手术效果确切。成人先天性巨结肠患者早期明确诊断并及时行手术治疗,是彻底治愈并减少病死率的有效方法。