全文获取类型
收费全文 | 70518篇 |
免费 | 6326篇 |
国内免费 | 2928篇 |
专业分类
耳鼻咽喉 | 717篇 |
儿科学 | 1770篇 |
妇产科学 | 1293篇 |
基础医学 | 9038篇 |
口腔科学 | 1278篇 |
临床医学 | 6581篇 |
内科学 | 6894篇 |
皮肤病学 | 1031篇 |
神经病学 | 2402篇 |
特种医学 | 3463篇 |
外国民族医学 | 57篇 |
外科学 | 8231篇 |
综合类 | 12359篇 |
现状与发展 | 21篇 |
预防医学 | 2081篇 |
眼科学 | 655篇 |
药学 | 4904篇 |
45篇 | |
中国医学 | 2281篇 |
肿瘤学 | 14671篇 |
出版年
2024年 | 122篇 |
2023年 | 945篇 |
2022年 | 1593篇 |
2021年 | 2999篇 |
2020年 | 2440篇 |
2019年 | 2184篇 |
2018年 | 2036篇 |
2017年 | 2307篇 |
2016年 | 2556篇 |
2015年 | 2700篇 |
2014年 | 4130篇 |
2013年 | 4212篇 |
2012年 | 3783篇 |
2011年 | 4215篇 |
2010年 | 3433篇 |
2009年 | 3417篇 |
2008年 | 3462篇 |
2007年 | 3760篇 |
2006年 | 3456篇 |
2005年 | 3084篇 |
2004年 | 2716篇 |
2003年 | 2424篇 |
2002年 | 2169篇 |
2001年 | 1972篇 |
2000年 | 1645篇 |
1999年 | 1487篇 |
1998年 | 1317篇 |
1997年 | 1276篇 |
1996年 | 1063篇 |
1995年 | 975篇 |
1994年 | 858篇 |
1993年 | 683篇 |
1992年 | 555篇 |
1991年 | 481篇 |
1990年 | 381篇 |
1989年 | 354篇 |
1988年 | 343篇 |
1987年 | 281篇 |
1986年 | 211篇 |
1985年 | 335篇 |
1984年 | 296篇 |
1983年 | 177篇 |
1982年 | 240篇 |
1981年 | 208篇 |
1980年 | 130篇 |
1979年 | 119篇 |
1978年 | 74篇 |
1977年 | 64篇 |
1976年 | 54篇 |
1975年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
目的 探讨PDCA 循环在消化道肿瘤伴糖尿病患者营养全程管理中的效果观察。方法 运用PDCA循环对80例不同程度营养不良的消化道肿瘤伴糖尿病患者实施营养全程管理,比较干预前后患者的体重、BMI指数、糖化血红蛋白、血红蛋白、总蛋白、白蛋白及球蛋白水平。结果 患者血红蛋白、总蛋白、白蛋白及球蛋白水平均有提高,比较差异均有统计学意义(P<0.05)。结论 PDCA循环管理在消化道肿瘤伴糖尿病患者营养全程管理中有较大的优势, 值得推广。 相似文献
32.
33.
34.
《Mayo Clinic proceedings. Mayo Clinic》2019,94(7):1321-1329
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been associated with the emergence of a new subset of autoimmune-like toxicities, known as immune-related adverse events. These toxicities differ depending on the agent, malignancy, and individual susceptibilities. Although the skin and colon are most commonly involved, any organ may be affected, including the liver, lungs, kidneys, and heart. Most of these toxicities are diagnosed by excluding other secondary infectious or inflammatory causes. Corticosteroids are commonly used for treatment of moderate and severe immune-related adverse events, although additional immunosuppressive therapy may occasionally be required. The occurrence of immune-related toxicities may require discontinuation of immunotherapy, depending on the specific toxicity and its severity. In this article, we provide a focused review to familiarize practicing clinicians with this important topic given that the use of immune checkpoint inhibitors continues to increase. 相似文献
35.
36.
37.
C. Carpentier C. Bobillier D. Blanchard B. Lallemant R. Garrel P. Gorphe R. Mastronicola S. Morinière 《European annals of otorhinolaryngology, head and neck diseases》2019,136(3):179-183
BackgroundCervical spondylodiscitis is a rare but severe complication of pharyngeal surgery.Material and methodsThis multicenter retrospective study reported all patients in the database of the French head and neck tumor study group (GETTEC) affected by cervical spondylodiscitis after transoral robotic surgery (TORS) for malignant pharyngeal tumor from January 2010 to January 2017.ObjectivesTo describe cases of post-TORS cervical spondylodiscitis, identify alarm signs, and determine optimal management of these potentially lethal complications.ResultsSeven patients from 6 centers were included. Carcinomas were located in the posterior pharyngeal wall. Tumor stage was T1 or T2. All patients had risk factors for spondylodiscitis. Mean time to diagnosis was 12.6 days. The interval between surgery and spondylodiscitis diagnosis ranged from 20 days to 4.5 months, for a mean 2.1 months. The most common symptom was neck pain (87%). Infections were polymicrobial; micro-organisms were isolated in 5 cases and managed by intravenous antibiotics, associated to medullary decompression surgery in 3 cases. Follow-up found favorable progression in 4 cases, and 3 deaths (mortality, 43%).ConclusionThis French multicenter study found elevated mortality in post-TORS spondylodiscitis, even in case of limited resection. Surgeons must be aware of this complication and alerted by persistent neck pain, fever, asthenia, impaired or delayed posterior pharyngeal wall wound healing or elevation of inflammatory markers. MRI is the most effective diagnostic radiological examination. 相似文献
38.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献39.
目的 探究原发灶定位与甲状腺乳头状微小癌(PTMC)颈侧区淋巴结转移的关系,评估超声检查预测颈侧区淋巴结转移的准确率。方法 回顾性分析2014年1月至2015年12月天津医科大学肿瘤医院收治的134例PTMC病人的临床资料,均行中央区淋巴结清扫+改良颈侧区淋巴结清扫。依据超声定位分组,分析癌灶位置与颈侧区淋巴结转移的关系。结果 颈侧各分区淋巴结转移发生率分别为:Ⅱ区30.6%、Ⅲ区50.7%、Ⅳ区57.5%、Ⅴ区11.3%。癌灶位于中上极者颈侧区淋巴结转移发生率高于癌灶位于下极者(89.7% vs. 75.7%,P=0.038),靠近外侧者较内侧者更易出现颈侧区淋巴结转移(93.7% vs. 81.4%,P=0.049)。超声检查判定Ⅱ、Ⅲ、Ⅳ、Ⅴ区淋巴结转移的敏感度分别为43.9%、85.3%、85.7%、14.3%;特异度为91.4%、57.6%、35.1%、99.1%。超声预测Ⅲ、Ⅳ区淋巴结转移敏感度较高,Ⅱ、Ⅴ区淋巴结转移特异度较高。结论 癌灶位置与甲状腺微小癌颈侧区淋巴结转移密切相关,超声可为临床确定颈侧区淋巴结的清扫范围提供依据。 相似文献
40.
舌癌患者手术及放化疗后会出现构音障碍、吞咽困难、口腔黏膜炎、口干、营养不良等并发症,使患者生存质量下降,甚至导致肿瘤的复发转移,影响生存期,单一方法往往顾此失彼。依托于中国中医科学院西苑医院肿瘤康复基地,杨宇飞教授在国内外调研考察基础上,结合中国国情,构建了一种“门诊多学科肿瘤康复模式”,在舌癌康复方面,以患者为中心,以中医肿瘤内科为主导,多学科共同参与,结合康复科、口腔科、营养科、药剂科等各科优势,形成全程个体化规范序贯康复方案,对患者及早进行康复,在放疗前进行预防性干预尤其重要,使患者能够快速缓解手术和放疗的不良反应,患者获益明显。现取两个典型案例总结其舌癌多学科康复的经验,以期为舌癌的康复提供借鉴。 相似文献