Psychopathology in females with attention-deficit/hyperactivity disorder: a controlled, five-year prospective study.

BACKGROUND: Despite the importance of understanding the long-term outcome of children with attention-deficit/hyperactivity disorder (ADHD), the available literature is predominantly based on male samples. This study estimated the lifetime burden of comorbid psychopathology in a large sample of girls with and without ADHD followed up over five years. METHODS: We conducted a blind, five-year prospective longitudinal study of girls with (n=140) and without (n=122) ADHD, aged 6-18 years at baseline, consecutively ascertained from either community pediatricians or psychiatrists at an academic medical center. At the five-year follow-up, 123 (88%) and 112 (92%) of the ADHD and control children, respectively, were re-assessed at a mean age of 16.7 years. Psychiatric disorders were assessed using blinded structured diagnostic interviews. RESULTS: At follow-up, females with ADHD were at significantly higher risk than controls to manifest disruptive behavior, mood and anxiety disorders, and substance dependence. The magnitude of increased risk was greatest for major depression and oppositional-defiant disorder, followed by substance dependence and anxiety disorders. CONCLUSIONS: These prospective follow-up findings documenting high morbidity associated with ADHD extend to females previously reported findings in male samples and underscore the importance of early recognition and intervention efforts for youth with ADHD of both genders.     

电噪声降低振动觉阈值的实验研究

本研究利用心理物理学实验来验证外加噪声可增强振动觉的随机共振现象。实验对象是人体手指光滑无毛处；所使用的外加噪声是不同于振动刺激的电噪声；采用二择一的强迫选择规则和变形上下法结合的实验方法。结果表明电噪声能降低所有受试者的振动感觉阈值，并表现出随机共振现象。文中所用测试方法能够滤除测试过程中心理干扰，因此所测结果具有客观，这为利用噪声现象来达到增强感觉的目的提供了进一步的依据。     

多种肿瘤标记物在卵巢恶性肿瘤化疗期间的监测作用

目的：探讨卵巢恶性肿瘤患术后疗期监测ＣＡ１２５、ＣＡ１９－９、ＣＡ２７－２９及铁蛋白（Ｆｅｒ）的价值。方法：对５５例卵巢恶性肿瘤患在第一年的６周期化疗前，后分别进行血清标志物检测。结果：在晚期卵巢恶性肿瘤及化疗期复发，ＣＡ１２５及ＣＡ２７－２９在６周期化疗后仍继续上升，而早期卵巢恶性肿瘤患及化疗期无复发这两种标记物在６周期化疗后下降。结论：在卵巢恶性肿瘤患手术后对预后估及化疗期间的随访中ＣＡ１２５和ＣＡ２７－２９较ＣＡ１９－９和Ｆｅｒ起着更为重要的作用。     

绝经缩瘤法治疗围绝经期子宫肌瘤思路探讨

子宫肌瘤是妇科常见疑难疾病,严重威胁女性身心健康。目前因西医药副作用大、手术复发率高,传统中医药疗法治愈率低、疗程长等缺点,各种治疗方案均不甚理想。从"七七"之年妇女的特殊生理病理特点出发,探讨采用中药绝经缩瘤疗法治疗围绝经期子宫肌瘤的机理,有望收到经断瘤缩之效,为临床治疗子宫肌瘤提供新思路。     

幽门螺旋菌与慢性萎缩性胃炎发病关系及防治研究

对485例胃病患者幽门螺旋菌(HP)总检出率为59.6%,从慢性萎缩性胃炎(CAG)患者胃粘膜分离出HP,在体外成功培养并连续接种传代。采用枯矾与阿斯匹林分别给小白鼠及家兔灌胃造成胃粘膜损伤后,再灌注HP,经细菌学、病理组织学检查,与人体CAG改变一致。证明HP符合Koch关于致病菌三定律。本研究从CAG细菌感染说出发,对53味中药及其组方进行抑菌试验,发现HP对三七、厚朴敏感;对乌梅、元胡中度敏感;对黄连、大黄高度敏感。对胃热型CAG用清热化瘀汤及活胃2号治疗70例,临床总有效率为97.2%,胄镜有效率为85.7%,病理有效率为80%,与三九胃泰对照组差异显著。     

The EsthetiCone™ abutment: three‐year results of a prospective multicenter investigation

The EsthetiCone? abutment, designed for subgingival restorative margins, makes it possible to achieve ideal esthetics, function, and predictability. This study included 200 EsthetiCone abutments placed in 50 partial or complete edentulous patients participating in a multicenter study performed in Europe and the United States. The patients were followed for 3 years and the marginal bone level of the implants was determined from intra-oral radiographs. During the follow-up period, a total of 9 of patients were withdrawn from the study. Based on the remaining patients, a total of 164 EsthetiCone abutments (82%) were evaluated through the 3-year follow-up visit. Only 1 EsthetiCone abutment failed during the study period, resulting in a cumulative success rate of 99.2% in the maxilla and 100% in the mandible after 3 years. No bone loss due to the usage of short abutment collars (1 mm) was seen in this study. The marginal bone resorption during the 3-year period did not exceed 1 mm as a mean neither for the 1 mm nor the higher abutments when analyzed separately. During the follow-up period, few complications were reported and they were all easily rectified without compromising the treatment success. The outcome of this study indicates that safe long-term and esthetically good results can be achieved when the Brånemark implants are loaded with EsthetiCone abutments. The reported need of a 3 mm peri-implant sulcus with an animal model was not confirmed with patients in this study.     

乌海市鼠情监测结果分析及灭鼠巩固的探讨

目的探讨灭鼠达标后，如何能长期的巩固灭鼠成果。方法每年春季巩固性饱和(敌鼠钠)或回合式(溴敌隆)投药1次，之后进行监测。结果17年来鼠密度一直波动在0．09％-3．86％之间。结论药物灭鼠”一役达标”法为一种有效的方法，巩固性投药是可取的巩固性策略，同时应积极探索生态防鼠。     

不育精液冷冻及解冻后上游处理对精子活率的影响

本文对男性不育患者４０份精液，根据精子的活动情况分为Ａ组（ｎ＝２４，精子活动率＞５０％），Ｂ组（ｎ＝１６，活动率＜５０％），精液均采用人工操作放置液氮超低温进行冷冻保存，一周以后进行解冻，精子复苏率分别为６８．９１％及６０．４９％；同时对３１例标本进行上游处理。Ａ组精子平均活率为（６１．３２±１３．０６）％。Ｂ组为（３２．９２±１１．６３）％，精子前向运动力分别为６．２６±１．３３级和４．０８±１．２５级；活动精子的回收率分别为５４．２６％和４７．５４％。通过分析发现，对精子质量低下，但有一定活动率的精子仍可作冷冻保存，并具有一定的可冻性及耐冻性。复苏后上游处理，不论其活率还是前向运动力均有明显提高（Ｐ＜０．０１），为做ＡＩＨ患者的精液冷冻保存及解冻后的精子作上游处理提供了一种实验方法及参考数据。     

医疗器械查房经验总结

介绍了设备管理的一项新方法 :器械查房。提出了树立“设备服务意识”的新观点。介绍了国外设备管理的一些经验。指出随着我国进入 WTO,医疗设备管理也应该与国际接轨